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001-es BibID:	BIBFORM102935
035-os BibID:	(Cikkazonosító)237 (WOS)000660775700003 (Scopus)85107152909
Első szerző:	Ónody Anna
Cím:	Interleukin-24 regulates mucosal remodeling in inflammatory bowel diseases / Anna Ónody, Apor Veres-Székely, Domonkos Pap, Réka Rokonay, Beáta Szebeni, Erna Sziksz, Franz Oswald, Gábor Veres, Áron Cseh, Attila J. Szabó, Ádám Vannay
Dátum:	2021
ISSN:	1479-5876
Megjegyzések:	Background: Recently, increased interleukin (IL)-24 expression has been demonstrated in the colon biopsies of adult patients with infammatory bowel disease (IBD). However, the role of IL-24 in the pathomechanism of IBD is still largely unknown. Methods: Presence of IL-24 was determined in the samples of children with IBD and in the colon of dextran sodium sulfate (DSS) treated mice. Efect of infammatory factors on IL24 expression was determined in peripheral blood (PBMCs) and lamina propria mononuclear cells (LPMCs). Also, the impact of IL-24 was investigated on HT-29 epithelial cells and CCD-18Co colon fbroblasts. Expression of tissue remodeling related genes was investigated in the colon of wild type (WT) mice locally treated with IL-24 and in the colon of DSS treated WT and Il20rb knock out (KO) mice. Results: Increased amount of IL-24 was demonstrated in the serum and colon samples of children with IBD and DSS treated mice compared to that of controls. IL-1?, LPS or H2O2 treatment increased the expression of IL24 in PBMCs and LPMCs. IL-24 treatment resulted in increased amount of TGF-? and PDGF-B in HT-29 cells and enhanced the expression of extracellular matrix (ECM)-related genes and the motility of CCD-18Co cells. Similarly, local IL-24 treatment increased the colonic Tgfb1 and Pdgfb expression of WT mice. Moreover, expression of pro-fbrotic Tgfb1 and Pdgfb were lower in the colon of DSS treated Il20rb KO compared to that of WT mice. The disease activity index of colitis was less severe in DSS treated Il20rb KO compared to WT mice. Conclusion: Our study suggest that IL-24 may play a signifcant role in the mucosal remodeling of patients with IBD by promoting pro-fbrotic processes
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Infammatory bowel diseases IBD Interleukin IL-24 Tissue remodeling Fibrosis
Megjelenés:	Journal of Translational Medicine. - 19 : 1 (2021), p. 237. -
További szerzők:	Veres-Székely Apor Pap Domonkos Rokonay Réka Szebeni Beáta Sziksz Erna Oswald Franz Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus) Cseh Áron Szabó J. A. Vannay Ádám
Pályázati támogatás:	K116928 OTKA K125470 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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