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001-es BibID:BIBFORM102944
Első szerző:Siposné Sohajda Réka
Cím:Introduction of nucleic acid amplification technology for blood screening in Hungary / Réka Siposné Sohajda, László Kokavecz, Klára Baróti-Tóth, Sándor Nagy, Melinda Paholcsek, Anikó Stágel
Dátum:2021
ISSN:1751-2816 1751-2824
Megjegyzések:Background & AimsWith this study, we intended to report our experiences aboutintroducing nucleic acid testing for blood donation screening for human immun-odeficiency virus, hepatitis B and C in Hungary. This study summarizes the expe-riences of nucleic acid amplification technology (NAT) screening of the first16 months.MethodsThe study was conducted from 5 June 2018 to 30 September 2019 intwo phases. During the first 7 months of the study, the NAT tests were performedin parallel with serology. The yields of the methods were compared. After the ini-tial seven months, only seronegative samples were tested by NAT. NAT tests wereperformed in minipools of 96.ResultsIn this 16-month period, nearly 400 000 donations were screened byNAT. During the first phase, almost 150 000 samples were tested in parallel byserology and NAT screening. NAT screening during Phase I failed to identify 4HCV- and 1 HBV-reactive donations. In the second phase, about 245 000seronegative samples were screened, with only one HBV reactive yield.ConclusionsNucleic acid amplification technology testing proven to be an opti-mal diagnostic adjunct to serological screening, since it can help to identify earlywindow period infections and occult hepatitis B infections. According to ourexperience however, the used pooling strategy represents a dilution rate ofnucleic acid targets, which makes identifying these types of infections difficult.According to our cost?benefit analysis, reducing the pool size to 60 would resultin a 60% sensitivity increase, at the expense of increasing the daily costs by25%.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
blood safety
donor screening
hepatitis B virus
hepatitis C virus
hu-man immunodeficiency virus
NAT testing
Megjelenés:ISBT Science Series. - 16 : 4 (2021), p. 321-329. -
További szerzők:Kokavecz László Baróti-Tóth Klára Nagy Sándor (Budapest) Paholcsek Melinda (1984-) (molekuláris biológus, genetikus) Stágel Anikó (genetika)
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