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001-es BibID:	BIBFORM103062
035-os BibID:	(cikkazonosító)2288 (WoS)000699281300001 (Scopus)85115886588
Első szerző:	Röszer Tamás (orvos, biológus)
Cím:	Adipose Tissue Immunometabolism and Apoptotic Cell Clearance / Tamás Röszer
Dátum:	2021
ISSN:	2073-4409
Megjegyzések:	The safe removal of apoptotic debris by macrophages-often referred to as efferocytosis-is crucial for maintaining tissue integrity and preventing self-immunity or tissue damaging inflammation. Macrophages clear tissues of hazardous materials from dying cells and ultimately adopt a pro-resolving activation state. However, adipocyte apoptosis is an inflammation-generating process, and the removal of apoptotic adipocytes by so-called adipose tissue macrophages triggers a sequence of events that lead to meta-inflammation and obesity-associated metabolic diseases. Signals that allow apoptotic cells to control macrophage immune functions are complex and involve metabolites released by the apoptotic cells and also metabolites produced by the macrophages during the digestion of apoptotic cell contents. This review provides a concise summary of the adipocyte-derived metabolites that potentially control adipose tissue macrophage immune functions and, hence, may induce or alleviate adipose tissue inflammation.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk apoptosis obesity meta-inflammation immunometabolism macrophage M2 macrophage efferocytosis phagocytosis
Megjelenés:	Cells. - 10 : 9 (2021), p. 1-16. -
Pályázati támogatás:	German Research Fund (DFG) RO-4856 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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