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001-es BibID:BIBFORM103063
035-os BibID:(Wos)000831161900001 (Scopus)85135075118
Első szerző:Röszer Tamás (orvos, biológus)
Cím:Metabolic impact of adipose tissue macrophages in the early postnatal life / Tamás Röszer
Dátum:2022
ISSN:0741-5400
Megjegyzések:Adipose tissue macrophages (ATMs) play key roles in metabolic inflammation, insulin resistance, adipose tissue fibrosis, and immune disorders associated with obesity. Research on ATM biology has mostly been conducted in the setting of adult obesity, since adipocyte hypertrophy is associated with a significant increase in ATM number. Signals that control ATM activation toward a proinflammatory or a proresolving phenotype also determine the developmental program and lipid metabolism of adipocytes after birth. ATMs are present at birth and actively participate in the synthesis of mediators, which induce lipolysis, mitobiogenesis, and mitochondrial uncoupling in adipocytes. ATMs in the newborn and the infant promote a lipolytic and fatty acid oxidizing adipocyte phenotype, which is essential to support the lipid-fueled metabolism, to maintain nonshivering thermogenesis and counteract an excessive adipose tissue expansion. Since adipose tissue metabolism in the early postnatal life determines obesity status in adulthood, early-life ATM functions may have a life-long impact.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
inflammation
macrophage
obesity
pediatric adiposity
Megjelenés:Journal Of Leukocyte Biology. - 112 : 6 (2022), p.1515-1524. -
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