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001-es BibID:	BIBFORM103092
035-os BibID:	(Wos)000487075100007 (Scopus)85064700512
Első szerző:	Ampem, Grace
Cím:	The environmental obesogen bisphenol A increases macrophage self-renewal / Grace Ampem, Alexandra Junginger, Haidong Yu, Lajos Balogh, Julianna Thuróczy, Marion E. Schneider, Tamás Röszer
Dátum:	2019
ISSN:	0302-766X
Megjegyzések:	Self-renewal of macrophages is important for the healthy development and replenishment of tissue-resident macrophage pools. How this mechanism is controlled by endocrine signals is still largely unexplored. Here, we show that the endocrine disruptor bisphenol A (BPA) increases macrophage self-renewal. This effect was associated with phosphorylation of extracellular signal-regulated kinase (ERK) and a slight increase in the expression of liver X receptor alpha (LXRalpha). We found that LXRaplha inhibition induced, while LXRalpha activation impeded, macrophage self-renewal. LXRalpha signaling hence may protect from excessive macrophage expansion. Self-renewing macrophages, however, had negligible LXR expression when compared with quiescent macrophages. Accordingly, tissue-resident macrophage pools, which are dominated by quiescent macrophages, were rich in LXRalpha-expressing macrophages. Overall, we show that BPA increases macrophage self-renewal and that this effect, at least in part, can be inhibited by increasing LXRalpha expression. Since BPA is accumulated in the adipose tissue, it has the potential to increase self-renewal of adipose tissue macrophages, leading to a condition that might negatively impact adipose tissue health.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Endocrine disruptors ERK LXR Obesity Obesogens
Megjelenés:	Cell And Tissue Research. - 378 : 1 (2019), p. 81-96. -
További szerzők:	Junginger, Alexandra Yu, Haidong Balogh Lajos Thuróczy Julianna Schneider, Marion E. Röszer Tamás (1979-) (orvos, biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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