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001-es BibID:	BIBFORM103519
035-os BibID:	(cikkazonosító)51 (Wos)000842252400001 (Scopus)85136101100
Első szerző:	Mathies, Franziska
Cím:	Multiple-pinhole collimators improve intra- and between-rater agreement and the certainty of the visual interpretation in dopamine transporter SPECT / Mathies Franziska, Apostolova Ivayla, Dierck Lena, Jacobi Janin, Kuen Katja, Sauer Markus, Schenk Michael, Klutmann Susanne, Forgács Attila, Buchert Ralph
Dátum:	2022
ISSN:	2191-219X
Megjegyzések:	Background: Multiple-pinhole (MPH) collimators improve the resolution-sensitivity trade-off compared to parallel-hole collimators. This study evaluated the impact of MPH collimators on intra- and between-rater agreement, and on the certainty of visual interpretation in dopamine transporter (DAT)-SPECT. Methods: The study included 71 patients (62.1 ? 12.7 y). Two SPECT acquisitions were performed in randomized order after a single injection of 182 ? 9 MBq 123I-FP-CIT, one with MPH and one with low-energy-high-resolution-high-sensitivity (LEHRHS) collimators. MPH projections were reconstructed with an iterative 3d Monte Carlo algorithm. LEHRHS projections were reconstructed with filtered backprojection (FBP) or with ordered-subsets expectation-maximization and resolution recovery (OSEM). Images were visually evaluated twice by three independent raters with respect to presence/absence of Parkinson-typical reduction of striatal 123I-FP-CIT uptake using a Likert 6-score (- 3 = clearly normal, ?, 3 = clearly reduced). In case of intra-rater discrepancy, an intra-rater consensus was obtained. Intra- and between-rater agreement with respect to the Likert score (6-score and dichotomized score) was characterized by Cohen's kappa. Results: Intra-rater kappa of visual scoring of MPH/LEHRHS-OSEM/LEHRHS-FBP images was 0.84 ? 0.12/0.73 ? 0.06/0.73 ? 0.08 (6-score, mean of three raters) and 1.00 ? 0.00/0.96 ? 0.04/0.97 ? 0.03 (dichotomized score). Between-rater kappa of visual scoring (intra-rater consensus) of MPH/LEHRHS-OSEM/LEHRHS-FBP images was 0.70 ? 0.06/0.63 ? 0.08/0.48 ? 0.05 (6-score, mean of three pairs of raters) and 1.00 ? 0.00/0.92 ? 0.04/0.90 ? 0.06 (dichotomized score). There was a decrease of (negative) Likert scores in normal DAT-SPECT by 0.87 ? 0.18 points from the LEHRHS-OSEM to the MPH setting. The (positive) Likert scores of reduced DAT-SPECT did not change on average. Conclusions: MPH collimators improve intra- and between-rater agreement as well as the certainty of the visual interpretation of DAT-SPECT.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	EJNMMI Research. - 12 : 1 (2022), p. 1-11. -
További szerzők:	Apostolova, Iva Dierck, Lena Jacobi, Janin Kuen, Katja Sauer, Markus Schenk, Michael Klutmann, Susanne Forgács Attila (1985-) (fizikus) Buchert, Ralph
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