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001-es BibID:	BIBFORM104821
035-os BibID:	(WOS)000598107300001 (Scopus)85109945359
Első szerző:	Böhm, Julia K.
Cím:	Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI) : a CENTER-TBI Analysis / Julia K. Böhm1, Helge Güting, Sophie Thorn, Nadine Schäfer, Victoria Rambach, Herbert Schöchl, Oliver Grottke, Rolf Rossaint, Simon Stanworth, Nicola Curry, Rolf Lefering, Marc Maegele, CENTERTBI Participants and Investigators
Dátum:	2020
ISSN:	1541-6933
Megjegyzések:	Abstract Background: Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated coagulopathy is poorly understood. Methods: This analysis, embedded in the prospective, multi-centred,observational Collaborative European Neuro Trauma Efectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, aimed to characterise the coagulopathy of TBI. Emphasis was placed on the acute phase following TBI, primary on subgroups of patients with abnormal coagula tion profle within 4 h of admission, and the impact of pre-injury anticoagulant and/or antiplatelet therapy. In order to minimise confounding factors, patients with isolated TBI (iTBI) (n=598) were selected for this analysis. Results: Haemostatic disorders were observed in approximately 20% of iTBI patients. In a subgroup analysis, patients with pre-injury anticoagulant and/or antiplatelet therapy had a twice exacerbated coagulation profle as likely as those without premedication. This was in turn associated with increased rates of mortality and unfavourable outcome post-injury. A multivariate analysis of iTBI patients without pre-injury anticoagulant therapy identifed several inde pendent risk factors for coagulopathy which were present at hospital admission. Glasgow Coma Scale (GCS) less than or equal to 8, base excess (BE) less than or equal to ?6, hypothermia and hypotension increased risk signifcantly. Conclusion: Consideration of these factors enables early prediction and risk stratifcation of acute coagulopathy after TBI, thus guiding clinical management.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk CENTER-TBI Traumatic brain injury Coagulopathy Risk factors
Megjelenés:	Neurocritical Care. - 35 : 1 (2020), p. 184-196. -
További szerzők:	Güting, Helge Thorn, Sophie Schäfer, Nadine Rambach, Victoria Schöchl, Herbert Grottke, Oliver Rossaint, Rolf Stanworth, Simon Curry, Nicola Lefering, Rolf Maegele, Marc Sándor János (1966-) (orvos-epidemiológus) CENTER-TBI Participants and Investigators
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