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001-es BibID:	BIBFORM105378
Első szerző:	Pikó Péter (biológus)
Cím:	Genetic factors exist behind the increased risk to reduced HDL-cholesterol level in Roma population / P. Pikó, S. Fiatal, Z. Kósa, J. Sándor, R. Ádány
Dátum:	2016
ISSN:	1101-1262
Megjegyzések:	Contact: adany.roza@sph.unideb.hu Background Roma is the largest ethnic minority in Europe. In our previous study on the prevalence of metabolic syndrome and its components reduced HDL-C level was found significantly more frequent in almost all age groups of the Hungarian Roma compared to the general population (Eur J Public Health 25:299, 2015). This fact in harmony with findings obtained in family and twin studies strongly suggests that plasma level of HDL-C is under genetic control. Our aim was to define whether genetic factors contribute to the higher prevalence of reduced HDL-C level and consequently to the increased susceptibility to atherosclerosis among Roma. Methods SNPs (N = 22) affecting HDL-cholesterol level in genes LIPC(G), CETP, GALNT2, HMGCP, ABCA1, KCTD10 and WWOX were analysed in the Hungarian Roma (N = 757) and general (N = 1787) populations. Genetic risk scores unweighted (GRS) and weighted (wGRS) were calculated and compared within the study populations. In addition the correlation between wGRS and the prevalence of reduced HDL-C level was analysed in both study groups stratified by quintiles. Results Both GRS and wGRS were found significantly higher in Roma than in the general population (GRS: 18.6 3.4 vs. 18.1 3.3, p = 0.001; wGRS: 0.54 0.10 vs. 0.52 0.11, p < 0.001). Only 3% of subjects in the Roma population were in the bottom fifth of the wGRS (wGRS 0.22) compared with 4.8% of those in the general population, while 7% of the Roma subjects were in the top fifth of the wGRS (wGRS 0.7) compared with 3.5% of those in the general population (p = 0.001). Furthermore the prevalence of reduced HDL-C level was significantly higher in the fifth quintile (with the highest genetic load) of the Roma population, than in that of the Hungarian general one (65% vs. 36.3%, p < 0.001). Conclusions The Roma population has increased genetic susceptibility to reduced HDL-C level and consequently to atherosclerosis as it is indicated by higher GRSs values in comparison with that for the general population.
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk
Megjelenés:	European Journal Of Public Health. - 26 : suppl1 (2016), p. 285. -
További szerzők:	Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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