Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM106690
035-os BibID:(scopus)85048288877 (wos)000434672900001
Első szerző:Parkes, Joanna E.
Cím:Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-γ autoantibodies in adult patients with myositis / Parkes Joanna E., Rothwell Simon, Oldroyd Alexander, Chinoy Hector, Lamb Janine A., Myositis Genetics Consortium (MYOGEN)
Dátum:2018
ISSN:1478-6354 1478-6362
Megjegyzések:Background The prevalence of dermatomyositis (DM) versus DM and polymyositis (PM) combined has been shown to be negatively associated with latitude. This observation has been attributed to increasing exposure to ultraviolet (UV) light towards the equator. In this study, we investigated whether differing genetic background in populations could contribute to this distribution of DM. Methods Case data derived from the MYOGEN (Myositis Genetics Consortium) Immunochip study (n =?1769) were used to model the association of DM prevalence and DM-specific autoantibodies with latitude. Control data (n =?9911) were used to model the relationship of human leucocyte antigen (HLA) associated with DM autoantibodies and DM or PM single-nucleotide polymorphisms (suggestive significance in the Immunochip project, P <?2.25???10??5) in healthy control subjects with latitude. All variables were analysed against latitude using ordered logistic regression, adjusted for sex. Results The prevalence of DM, as a proportion of DM and PM combined, and the presence of anti-transcription intermediary factor 1 (anti-TIF1-?) autoantibodies were both significantly negatively associated with latitude (OR 0.96, 95% CI 0.95?0.98, P <?0.001; and OR 0.95, 95% CI 0.92?0.99, P =?0.004, respectively). HLA alleles significantly associated with anti-Mi-2 and anti-TIF1-? autoantibodies also were strongly negatively associated with latitude (OR 0.97, 95% CI 0.96?0.98, P <?0.001 and OR 0.98, 95% CI 0.97?0.99, P <?0.001, respectively). The frequency of five PM- or DM-associated SNPs showed a significant association with latitude (P <?0.05), and the direction of four of these associations was consistent with the latitude associations of the clinical phenotypes. Conclusions These results lend some support to the hypothesis that genetic background, in addition to UV exposure, may contribute to the distribution of DM.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Anti-Mi-2
Anti-TIF1-γ
Dermatomyositis
Latitude
Polymyositis
Ultraviolet light
Megjelenés:Arthritis Research & Therapy. - 20 : 1 (2018), p. 1-5. -
További szerzők:Rothwell, Simon Oldroyd, Alexander Chinoy, Hector Lamb, Janine A. Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Myositis Genetics Consortium (MYOGEN)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1