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001-es BibID:	BIBFORM110517
035-os BibID:	(cikkazonosító)6942 (Scopus)85158060599 (WoS)000981008100001
Első szerző:	Képes Zita (orvos)
Cím:	Overview of Prostaglandin E2 (PGE2)-Targeting Radiolabelled Imaging Probes from Preclinical Perspective : Lessons Learned and Road Ahead / Képes Zita, Dénes Noémi, Kertész István, Hajdu István, Trencsényi György
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	As malignancies still represent one of the major health concerns worldwide, early tumor identification is among the priorities of today's science. Given the strong association between cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2), PGE2 receptors (EPs), and carcinogenesis, target-specific molecules directed towards the components of the COX2/PGE2/EP axis seem to be promising imaging probes in the diagnostics of PGE2pos. neoplasms and in the design of anti-cancer drugs. Featured with outstanding inclusion forming capability, β-cyclodextrins (CDs) including randomly methylated β-CD (RAMEB) were reported to complex with PGE2. Therefore, radiolabelled β-CDs could be valuable vectors in the molecular imaging of PGE2-related tumorigenesis. In vivo preclinical small animal model systems applying positron emission tomography (PET) ensure a well-suited scenario for the assessment of PGE2-affine labelled CD derivatives. Previous translational studies dealt with the evaluation of the tumor-homing capability of Gallium-68 (68Ga) and Bismuth-205/206 (205/206Bi)-appended β-CD compounds conjugated with chelator NODAGA or DOTAGA: [68Ga]Ga-NODAGA-2-hydroxypropyl-β-cyclodextrin/HPBCD, [68Ga]Ga-NODAGARAMEB, [68Ga]Ga-DOTAGA-RAMEB, and [205/206Bi]Bi-DOTAGA-RAMEB in experimental tumors with different PGE2 expression. These imaging probes project the establishment of tailor-made PET diagnostics of PGE2pos. malignancies. In the present review, we provide a detailed overview of the in vivo investigations of radiolabelled PGE2-directed CDs, highlighting the importance of the integration of translational discoveries into routine clinical usage.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Bismuth-205/206 (205/206Bi) cyclodextrins (CDs) Gallium-68 (68Ga) 2-hydroxypropyl-β-cyclodextrin (HPBCD) positron emission tomography (PET) prostaglandin E2 (PGE2) randomly methylated β-CD (RAMEB)
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 8 (2023), p. 1-15. -
További szerzők:	Dénes Noémi (1992-) (vegyész) Kertész István (1966-) (vegyész) Hajdu István (1981-) (vegyész) Trencsényi György (1978-) (biológus, biokémikus, molekuláris biológus)
Pályázati támogatás:	János Bolyai Research Scholarship of the Hungarian Academy of Sciences (bo_328_21) Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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