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001-es BibID:	BIBFORM111042
035-os BibID:	(cikkazonosító)1484 (WoS)000987004100001 (Scopus)85159145210
Első szerző:	Ilie, Daniela Elena
Cím:	Kompetitive Allele Specific PCR Genotyping of 89 SNPs in Romanian Spotted and Romanian Brown Cattle Breeds and Their Association with Clinical Mastitis / Daniela Elena Ilie; Dinu Gavojdian; Szilvia Kusza; Radu Ionel Neamț; Alexandru Eugeniu Mizeranschi; Ciprian Valentin Mihali; Ludovic Toma Cziszter
Dátum:	2023
ISSN:	2076-2615
Megjegyzések:	Mastitis is the most common production disease in the dairy sector worldwide, its incidence being associated with both cows` exposure to bacteria and the cows` genetic make-up for resistance to pathogens. The objective of our study was to analyse 89 missense SNPs belonging to six genes (CXCR2, CXCL8, TLR4, BRCA1, LTF, BOLA-DRB3), which were found to be associated with genetic resistance or susceptibility to mastitis. A total of 298 cattle (250 Romanian Spotted and 48 Romanian Brown) were genotyped by Kompetitive Allele Specific PCR (KASP) and a chi-squared test was used for genetic association studies with clinical mastitis. A total of 35 SNPs (39.3%) among the selected 89 SNPs were successfully genotyped, of which 31 markers were monomorphic. The polymorphic markers were found in two genes: TLR4 (rs460053411) and BOLA-DRB3 (rs42309897, rs208816121, rs110124025). The polymorphic SNPs with MAF > 5% and call rates > 95% were used for the association study. The results showed that rs110124025 in the BOLA-DRB3 gene was significantly associated with mastitis prevalence (p ? 0.05) in both investigated breeds. Current results show that the SNP rs110124025 in the BOLA-DRB3 gene can be used as a candidate genetic marker in selection for mastitis resistance in Romanian dairy cattle.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk KASP mastitis polymorphism Romanian Brown Romanian Spotted
Megjelenés:	Animals. - 13 : 9 (2023), p. 1-13. -
További szerzők:	Gavojdian, Dinu Kusza Szilvia (1979-) (agrármérnök) Neamt, Radu Mizeranschi, Alexandru Eugeniu Ciprian, Valentin Mihali Cziszter, Ludovic Toma
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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