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001-es BibID:	BIBFORM111426
035-os BibID:	(WoS)001046245400001 (Scopus)85164978593
Első szerző:	European Association for the Study of the Liver
Cím:	EASL Clinical Practice Guidelines on acute-on-chronic liver failure / European Association for the Study of the Liver
Dátum:	2023
ISSN:	0168-8278
Megjegyzések:	Acute-on-chronic liver failure (ACLF), which has described relatively recently (2013), is a severe form of acutly decompensated cirrhosis characterized by the existence of organ system failures(s) and a high risk of short-term mortality. ACLF is caused by an excessive systemic inflammatory response triggered by precipitants that are clinically apparent (e.g., proven microbial infection with sepsis, severe alcohol-related hepatitis) or not. Since the description of ACLF, some important studies have suggested that patients with ACLF may benefit from liver transplantation and because of this, should be urgently stabilised for transplantation by receiving appropriate treatment of identified precipitants, and full general management, including support of organ systems in the intensive care unit (ICU). The objective of the present CPGs is to provide recommendations to help clinicians recognise ACLF, make triage decisions (ICU vs. no ICU), identify and manage acute precipitants, identify organ systems that require support or replacement, define potential criteria for futility of intensive care, and identify potential indicators for liver transplantation. Based on an in-depth review of the relevant literature we provide recommendations to navigate clinical dilemmas followed by supporting text. The recommendations are graded according to the Oxford Centre for Evidence-Based Medicine system and categorized as 'weak' or 'strong'. We aim to provide the best available evidence to aid the clinical decision-making process in the management of patients with ACLF.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of Hepatology. - 79 : 2 (2023), p. 461-491. -
További szerzők:	Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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