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001-es BibID:	BIBFORM113592
035-os BibID:	(cikkazonosító)3571 (Scopus)85154546400 (WoS)000980864300001
Első szerző:	Téglás Tímea
Cím:	The Flavonoid Rich Black Currant (Ribes nigrum) Ethanolic Gemmotherapy Extract Elicits Neuroprotective Effect by Preventing Microglial Body Swelling in Hippocampus and Reduces Serum TNF-alfa Level : Pilot Study / Tímea Téglás, Emőke Mihok, Zoltán Cziáky, Neli-Kinga Oláh, Csaba Nyakas, Endre Máthé
Dátum:	2023
ISSN:	1420-3049
Megjegyzések:	Many plant-derived flavonoids are known for their anti-neuroinflammatory and anti-neurodegenerative effects. The fruits and leaves of the black currant (BC, Ribes nigrum) contain these phytochemicals with therapeutic benefits. The current study presents a report on a standardized BC gemmotherapy extract (BC-GTE) that is prepared from fresh buds. It provides details about the phytoconstituent profile specific to the extract as well as the associated antioxidant and anti-neuroinflammatory properties. The reported BC-GTE was found to contain approximately 133 phytonutrients, making it unique in its composition. Furthermore, this is the first report to quantify the presence of significant flavonoids such as luteolin, quercetin, apigenin, and kaempferol. Drosophila melanogaster-based tests revealed no cytotoxic but nutritive effects. We also demonstrated that adult male Wistar rats, pretreated with the analyzed BC-GTE and assessed after lipopolysac- charide (LPS) injection, did not show any apparent increase in body size in the microglial cells located in the hippocampal CA1 region, while in control experiments, the activation of microglia was evident. Moreover, no elevated levels of serum-specific TNF-? were observed under the LPS-induced neuroinflammatory condition. The analyzed BC-GTE's specific flavonoid content, along with the experimental data based on an LPS-induced inflammatory model, suggest that it possesses anti-neuroinflammatory/neuroprotective properties. This indicates that the studied BC-GTE has the potential to be used as a GTE-based complementary therapeutic approach.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Ribes nigrum gemmotherapy neuroinflammation TNF-α microglia
Megjelenés:	Molecules. - 28 : 8 (2023), p. 1-17. -
További szerzők:	Mihok Emőke Cziáky Zoltán Oláh Neli Kinga Nyakas Csaba Máthé Endre (1964-) (genetikus, molekuláris sejtbiológus)
Pályázati támogatás:	ÚNKP-18-3 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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