Találati lista | Tudóstér

001-es BibID:	BIBFORM115266
035-os BibID:	(cikkazonosító)e0296
Első szerző:	Tornai Dávid (hepatológia, biomarker kutatás)
Cím:	A novel score of IL-13 and age predicts 90-day mortality in severe alcohol-associated hepatitis : a multicenter plasma biomarker analysis / David Tornai, Mack Mitchell, Craig J. McClain, Srinivasan Dasarathy, Arthur McCullough, Svetlana Radaeva, Aimee Kroll-Desrosiers, JungAe Lee, Bruce Barton, Gyongyi Szabo
Dátum:	2023
ISSN:	2471-254X
Megjegyzések:	Background: Severe alcoholic hepatitis (AH) has a high short-term mortality rate. The Model for End-Stage Liver Disease (MELD) assesses disease severity and mortality, however, it is not specific for AH. We screened plasma samples from severe AH patients for biomarkers of multiple pathological processes and identified predictors of short-term mortality. Methods: Plasma was collected at baseline from 85 severe AH patients (MELD?20, MDF?32) enrolled in the DASH clinical trial (investigating IL-1receptor antagonist+pentoxifylline+zinc vs. methylprednisolone+placebo). Samples were analyzed for 43 biomarkers and the markers' association with 28 and 90-day mortality was assessed. Results: Thirty-one (36.5%) patients died during the 90-day follow-up with similar ratios in the treatment groups. Eight biomarkers showed association with mortality. Interleukin-6, IL-22, IFN-?2, sTNF-R1, lipocalin-2 and ?-fetoprotein levels were associated with 28-day, while IL-6, IL-13 and endotoxin levels with 90-day mortality. In multivariable Cox regression, encephalopathy, lipocalin-2 and ?-fetoprotein levels were independent predictors of 28-day mortality and IL-6, IL-13, INR levels and age were independent predictors of 90-day mortality. The combination of IL-13 and age had superior performance predicting 90-day mortality compared to MELD in the total cohort and the individual treatment groups. Conclusions: We identified predictors of short-term mortality in a cohort exclusively involving severe AH patients. We created a composite score of IL-13 and age that predicts 90-day mortality regardless of treatment type with a performance superior to MELD in severe AH.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk anakinra interleukin short-term mortality composite score prognosis
Megjelenés:	Hepatology Communications. - 7 : 12 (2023), p. 1-13. -
További szerzők:	Mitchell, Mack McClain, Craig Dasarathy, Srinivasan McCullough, Arthur Radaeva, Svetlana Kroll-Desrosiers, Aimee Lee, JungAe Barton, Bruce Szabó Gyöngyi
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon: