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001-es BibID:	BIBFORM115431
035-os BibID:	(cikkazonosító)15308 (WoS)001091853400001 (Scopus)85175252490
Első szerző:	Juhász Lilla (általános orvos)
Cím:	Decreased Serum Stromal Cell-Derived Factor-1 in Patients with Familial Hypercholesterolemia and Its Strong Correlation with Lipoprotein Subfractions / Lilla Juhász, Hajnalka Lőrincz, Anita Szentpéteri, Nóra Tóth, Éva Varga, György Paragh, Mariann Harangi
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	Stromal cell-derived factor-1 (SDF-1) is a chemokine that exerts multifaceted roles in atherosclerosis. However, its association with hyperlipidemia is contradictory. To date, serum SDF-1 and its correlations with lipid fractions and subfractions in heterozygous familial hypercholesterolemia (HeFH) have not been investigated. Eighty-one untreated patients with HeFH and 32 healthy control subjects were enrolled in the study. Serum SDF-1, oxidized LDL (oxLDL) and myeloperoxidase (MPO) were determined by ELISA. Lipoprotein subfractions were detected by Lipoprint. We diagnosed FH using the Dutch Lipid Clinic Network criteria. Significantly lower serum SDF-1 was found in HeFH patients compared to healthy controls. Significant negative correlations were detected between serum total cholesterol, triglycerides, LDL-cholesterol (LDL-C), apolipoprotein B100 (ApoB100) and SDF-1. Furthermore, serum SDF-1 negatively correlated with VLDL and IDL, as well as large LDL and large and intermediate HDL subfractions, while there was a positive correlation between mean LDL-size, small HDL and SDF-1. SDF-1 negatively correlated with oxLDL and MPO. A backward stepwise multiple regression analysis showed that the best predictors of serum SDF-1 were VLDL and oxLDL. The strong correlation of SDF-1 with lipid fractions and subfractions highlights the potential common pathways of SDF-1 and lipoprotein metabolism, which supports the role of SDF-1 in atherogenesis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk stromal cell-derived factor-1 familial hypercholesterolemia oxidized low-density lipoprotein very low-density lipoprotein large low-density lipoprotein vascular repair
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 20 (2023), p. 1-14. -
További szerzők:	Lőrincz Hajnalka (1986-) (biológus) Szentpéteri Anita (1988-) (biológus) Tóth Nóra (1994-) (orvos) Varga Éva (1982-) (belgyógyász) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus)
Pályázati támogatás:	142273 OTKA TKP2021-EGA-18 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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