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001-es BibID:	BIBFORM116067
035-os BibID:	(cikkazonosító)e34614 (Scopus)85167678498 (WOS)001046217500082
Első szerző:	Awuah, Wireko Andrew
Cím:	Circadian rhythm in systemic autoimmune conditions : Potential of chrono-immunology in clinical practice: A narrative review / Awuah Wireko Andrew, Huang Helen, Kalmanovich Jacob, Mehta Aashna, Mikhailova Tatiana, Ng Jyi Cheng, Abdul-Rahman Toufik, Adebusoye Favour Tope, Tan Joecelyn Kirani, Kamanousa Karl, Ferreira Tomas, Roy Sakshi, Kundu Mrinmoy, Yarlagadda Rohan, Mukerjee Nobendu, Alexiou Athanasios, Papadakis Marios
Dátum:	2023
ISSN:	0025-7974
Megjegyzések:	The circadian rhythm (CR) is a fundamental biological process regulated by the Earth's rotation and solar cycles. It plays a critical role in various bodily functions, and its dysregulation can have systemic effects. These effects impact metabolism, redox homeostasis, cell cycle regulation, gut microbiota, cognition, and immune response. Immune mediators, cycle proteins, and hormones exhibit circadian oscillations, supporting optimal immune function and defence against pathogens. Sleep deprivation and disruptions challenge the regulatory mechanisms, making immune responses vulnerable. Altered CR pathways have been implicated in diseases such as diabetes, neurological conditions, and systemic autoimmune diseases (SADs). SADs involve abnormal immune responses to self-antigens, with genetic and environmental factors disrupting self-tolerance and contributing to conditions like Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Inflammatory Myositis. Dysregulated CR may lead to increased production of pro-inflammatory cytokines, contributing to the systemic responses observed in SADs. Sleep disturbances significantly impact the quality of life of patients with SADs; however, they are often overlooked. The relationship between sleep and autoimmune conditions, whether causal or consequential to CR dysregulation, remains unclear. Chrono-immunology investigates the role of CR in immunity, offering potential for targeted therapies in autoimmune conditions. This paper provides an overview of the connections between sleep and autoimmune conditions, highlighting the importance of recognizing sleep disturbances in SADs and the need for further research into the complex relationship between the CR and autoimmune diseases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk chrono-immunology circadian rhythm systemic autoimmune diseases
Megjelenés:	Medicine. - 102 : 32 (2023), p. 1-10. -
További szerzők:	Huang, Helen Kalmanovich, Jacob Mehta, Aashna Mikhailova, Tatiana Cheng Ng, Jyi Abdul-Rahman, Toufik Adebusoye, Favour T. Tan, Joecelyn Kirani Kamanousa, Karl Ferreira, Tomas Roy, Sakshi Kundu, Mrinmoy Yarlagadda, Rohan Mukerjee, Nobendu Alexiou, Athanasios Papadakis, Marios
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