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001-es BibID:	BIBFORM116556
035-os BibID:	(Scopus)85137480143 (WoS)000851523500001
Első szerző:	Junxian, Li
Cím:	The homeostasis and therapeutic applications of innate and adaptive immune cells in periodontitis / Li Junxian, Mojtaba Mehrabanian, Hassan Mivehchi, Morteza Banakar, Enas Abdalla Etajuri
Dátum:	2023
ISSN:	1354-523X
Megjegyzések:	Objectives: Periodontitis (PD) is one of the most common dental disorders. This chronic oral inflammation is caused by complicated interrelations between bacterial infections, dysregulated immune reactions, and environmental risk factors. A dysregulated immune response can lead to inflammatory bone resorption by allowing the recruitment of pro-inflammatory immune cells to the periodontal tissues. Subjects: The recruitment of innate and adaptive immune cells in PD initiates the acute and following chronic inflammatory processes. The inflamed tissues, on the other hand, can be restored if the anti-inflammatory lineages are predominantly established in the periodontal tissues. Therefore, we aimed to review the published literature to provide an overview of the existing knowledge about the role of immune cells in PD, as well as their possible therapeutic applications. Results: Experimental studies showed that drugs/systems that negatively regulate inflammatory cells in the body, as well as interventions aimed at increasing the number of anti-inflammatory cells such as Tregs and Bregs, can both help in the healing process of PD. Conclusion: Targeting immune cells or their positive/negative manipulations has been demonstrated to be an effective therapeutic method. However, to use this sort of immunotherapy in humans, further pre-clinical investigations, as well as randomized clinical trials, are required.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk cell therapy immune cells immunotherapy periodontitis
Megjelenés:	Oral Diseases. - 29 : 7 (2023), p. 2552-2564. -
További szerzők:	Mehrabanian, Mojtaba Mivehchi, Hassan Banakar, Morteza Etajuri, Enas Abdalla
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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