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001-es BibID:	BIBFORM117130
035-os BibID:	(cikkazonosító)eadi3363 (Scopus)85179023387
Első szerző:	Roselletti, Elena
Cím:	Zinc prevents vaginal candidiasis by inhibiting expression of an inflammatory fungal protein / Roselletti Elena, Pericolini Eva, Nore Alexandre, Takacs Peter, Kozma Bence, Sala Arianna, De Seta Francesco, Comar Manola, Usher Jane, Brown Gordon D., Wilson Duncan
Dátum:	2023
ISSN:	1946-6234
Megjegyzések:	Candida causes an estimated half-billion cases of vulvovaginal candidiasis (VVC) every year. VVC is most commonly caused by Candida albicans, which, in this setting, triggers nonprotective neutrophil infiltration, aggressive local inflammation, and symptomatic disease. Despite its prevalence, little is known about the molecular mechanisms underpinning the immunopathology of this fungal infection. In this study, we describe the molecular determinant of VVC immunopathology and a potentially straightforward way to prevent disease. In response to zinc limitation, C. albicans releases a trace mineral binding molecule called Pra1 (pH-regulated antigen). Here, we show that the PRA1 gene is strongly up-regulated during vaginal infections and that its expression positively correlated with proinflammatory cytokine concentrations in women. Genetic deletion of PRA1 prevented vaginal inflammation in mice, and application of a zinc solution down-regulated expression of the gene and also blocked immunopathology. We also show that treatment of women suffering from recurrent VVC with a zinc gel prevented reinfections. We have therefore identified a key mediator of symptomatic VVC, giving us an opportunity to develop a range of preventative measures for combatting this disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Science Translational Medicine. - 15 : 725 (2023), p. 1-10. -
További szerzők:	Pericolini, Eva Nore, Alexandre Takács Péter (1968-) (szülész-nőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász) Sala, Arianna De Seta, Francesco Comar, Manola Usher, Jane Brown, Gordon D. Wilson, Duncan
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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