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001-es BibID:	BIBFORM117633
035-os BibID:	(cikkazonosító)664 (WoS)001141423100001 (Scopus)85182205296
Első szerző:	Trencsényi György (biológus, biokémikus, molekuláris biológus)
Cím:	Targeted Radium Alpha Therapy in the Era of Nanomedicine: In Vivo Results / György Trencsényi, Csaba Csikos, Zita Képes
Dátum:	2024
ISSN:	1422-0067
Megjegyzések:	Targeted alpha-particle therapy using radionuclides with alpha emission is a rapidly developing area in modern cancer treatment. To selectively deliver alpha-emitting isotopes to tumors, targeting vectors, including monoclonal antibodies, peptides, small molecule inhibitors, or other biomolecules, are attached to them, which ensures specific binding to tumor-related antigens and cell surface receptors. Although earlier studies have already demonstrated the anti-tumor potential of alpha-emitting radium (Ra) isotopes-Radium-223 and Radium-224 (Ra-223/224)-in the treatment of skeletal metastases, their inability to complex with target-specific moieties hindered application beyond bone targeting. To exploit the therapeutic gains of Ra across a wider spectrum of cancers, nanoparticles have recently been embraced as carriers to ensure the linkage of Ra-223/224 to target-affine vectors. Exemplified by prior findings, Ra was successfully bound to several nano/microparticles, including lanthanum phosphate, nanozeolites, barium sulfate, hydroxyapatite, calcium carbonate, gypsum, celestine, or liposomes. Despite the lengthened tumor retention and the related improvement in the radiotherapeutic effect of Ra-223/224 coupled to nanoparticles, the in vivo assessment of the radiolabeled nanoprobes is a prerequisite prior to clinical usage. For this purpose, experimental xenotransplant models of different cancers provide a well-suited scenario. Herein, we summarize the latest achievements with Ra-223/224-doped nanoparticles and related advances in targeted alpha radiotherapy.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk nanoparticles preclinical Radium-223/224 (223/224Ra) targeted alpha-particle therapy xenotransplants
Megjelenés:	International Journal Of Molecular Sciences. - 25 : 1 (2024), p. 1-30. -
További szerzők:	Csíkos Csaba Képes Zita (1991-) (orvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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