Találati lista | Tudóstér

001-es BibID:	BIBFORM118019
035-os BibID:	(cikkazonosító)e202300784 (WoS)001153927400001 (Scopus)85183623079
Első szerző:	Laine, Sophie
Cím:	Structural, stability and relaxation features of lanthanide-complexes designed for multimodal imaging detection of enzyme activities / Sophie Laine, Rémy Jouclas, Célia S Bonnet, PascalRetailleau, Vincent Steinmetz, Agnès Pallier, Zoltán Garda, Gyula Tircsó, Philippe Durand, Éva Tóth
Dátum:	2024
ISSN:	1434-1948
Megjegyzések:	Lanthanide complexes of DO3A-derivative ligands bearing a pyridine-carbamate (L1) or pyridine-amine (L2) arm have potential interest in the design of enzymatically activated imaging probes. Solid-state X-ray structures for CeL1 and YbL2 both demonstrate twisted square antiprismatic geometry, with the metal ion in a nine- or an eight-coordinate environment, respectively. As assessed by pH-potentiometry, in solution lanthanide ions form more stable complexes with the nonadentate L1 than with the octadentate L2 ligand (logKML = 18.7-21.1 vs. 16.7-18.6, respectively), while stability constants are similar for L1 and L2 chelates of Mg2+, Ca2+, Zn2+ or Cu2+. The kinetic inertness of GdL1 is exceptionally high with an estimated dissociation half-life ~108 h at pH 7.4, while LnL2 (Ln = Ce, Gd, Yb) complexes have 3-4 orders of magnitude faster dissociation, related to the presence of the protonatable, non-coordinating amine function. The water exchange rate determined for the monohydrated GdL2 (kex298 = 1.3x106 s-1) shows a threefold decrease with respect to GdDOTA, as consequence of a reduction in the negative charge and in the steric crowding around the water binding site, both important in dissociatively activated water exchange processes.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Lanthanide complexes macrocyclic ligands structure stability inertness
Megjelenés:	European Journal Of Inorganic Chemistry. - [Epub ahead of print] (2024), p.1-13. -
További szerzők:	Laine, Sophie Jouclas, Rémy Bonnet, Célia S. Retailleau, Pascal Steinmetz, Vincent Pallier, Agnes Garda Zoltán (1989-) (vegyész) Tircsó Gyula (1977-) (vegyész, kémia tanár) Durand, Philippe Tóth Éva (1967-) (koordinációs kémia)
Pályázati támogatás:	PD-138064 OTKA K-128201 OTKA K-134694 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: