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001-es BibID:	BIBFORM119418
035-os BibID:	(cikkazonosító)3238
Első szerző:	Pikó Péter (biológus)
Cím:	Genetic Background of Acute Heart Rate Response to Exercise / Péter Pikó, Habib Al Ashkar, Nóra Kovács, Ilona Veres-Balajti, Róza Ádány
Dátum:	2024
ISSN:	1422-0067
Megjegyzések:	The acute heart rate response (AHRR) to physical activity, which refers to the change in heart rate during and after exercise, has been associated with cardiovascular and all-cause mortality. Previous studies have shown that AHRR is significantly determined by genetics in addition to environmental and lifestyle factors. The aim of this study was to investigate the genetic background of AHRR by analysing ten single nucleotide polymorphisms (SNPs) associated with leisure-time physical activity (LTPA) in 620 samples from the Hungarian population. The AHRR can be characterised as the difference between post-exercise and resting heart rate, i.e., the delta heart rate (?HR) defined by the YMCA 3 min step test, with a lower value indicating better cardiovascular fitness. The association of SNPs with ?HR was analysed both separately and in combination using an optimised polygenic score (oPGS). The results showed that five SNPs (rs10252228, rs459465, rs6022999, rs8097348, and rs12405556) had at least nominally significant (p < 0.05) individual associations with ?HR. After optimizing the PGS, a cumulative effect was observed for eight SNPs (rs6022999, rs12405556, rs459465, rs10252228, rs8097348, rs10887741, rs12612420, and rs7023003) that had a strong and statistically significant association with ?HR (B = ?2.51, 95% CI: ?3.46??1.76; p = 2.99 ? 10?9). Of the four main domains of physical activity, the oPGS showed a significant positive association only with LTPA (B = 84.60; 95%CI: 25.23?143.98; p = 0.005). In conclusion, our results suggest that the SNPs we investigated influence individual leisure-time physical activity, mediated by their effects on the acute heart rate response.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk acute heart rate response cardiorespiratory fitness YMCA 3 min step test optimised polygenic score single nucleotide polymorphism leisure-time physical activity
Megjelenés:	International Journal Of Molecular Sciences. - 25 : 6 (2024), p. 1-12. -
További szerzők:	Al Ashkar, Habib Kovács Nóra (1989-) (népegészségügyi szakember) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP TK2016-78 MTA TKCS-2021/32 Egyéb 135784 OTKA National Research, Development, and Innovation Office (NKFIH) RRF-2.3.1-21-2022-00006 Egyéb ÚNKP-23-5-DE-494 Egyéb BO/00513/23/5 MTA
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