Találati lista | Tudóstér

001-es BibID:	bibEBI00008631
Első szerző:	Kiss Erzsébet
Cím:	Interactions of Al(III) with phosphorylated amino acids / Erzsébet Kiss, Andrea Lakatos, István Bányai, Tamás Kiss
Dátum:	1998
ISSN:	0162-0134
Megjegyzések:	In order to assess the Al(III)-binding abilities of phosphorylated proteins and peptides, the interactions of Al(III) with the building blocks O-phosphoserine (PSer) and O-phosphotyrosine (PTyr) were studied. pH-metric and 31P NMR measurements were carried out to determine the stoichiometries and stability constants of the complexes formed, and to establish the most probable binding sites of the metal ion. PSer was found to bind Al(III) in a monodentate manner at the phosphate moiety, and in a tridentate manner with the simultaneous coordination of all donor groups. PTyr binds Al(III) only at the separate phosphate function. Citric acid (Cit) proved to be a stronger Al(III) binder at the physiological pH, though, it was able to displace PSer only in a rather slow process through formation of the trinuclear species Al3(Cit)3(OH). The results were used to evaluate the potential role of Al(III) in inducing the formation of neurofilamentous aggregates in neurological disorders.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Inorganic Biochemistry. - 69 : 3 (1998), p. 145-151. -
További szerzők:	Lakatos Andrea Bányai István (1953-) (vegyész) Kiss Tamás
Pályázati támogatás:	OTKA/T7458 OTKA OTKA/T23776 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon: