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001-es BibID:	BIBFORM018458
Első szerző:	Kecskeméti Valéria
Cím:	Norfluoxetine and fluoxetine have similar anticonvulsant and Ca channel blocking potencies / Kecskeméti V., Rusznák Z., Riba P., Pál B., Wagner R., Harasztosi C., Nánási P. P., Szűcs G.
Dátum:	2005
ISSN:	0361-9230
Megjegyzések:	Norfluoxetine is the most important active metabolite of the widely used antidepressant fluoxetine but little is known about its pharmacological actions. In this study the anticonvulsant actions of norfluoxetine and fluoxetine were studied and compared to those of phenytoin and clonazepam in pentylenetetrazol-induced mouse epilepsy models. Pretreatment with fluoxetine or norfluoxetine (20 mg/kg s.c.), as well as phenytoin (30 mg/kg s.c.) and clonazepam (0.1 mg/kg s.c.) significantly increased both the rate and duration of survival, demonstratinga significant protective effect against pentylenetetrazol-induced epilepsy. These effects of norfluoxetine were similar to those of fluoxetine. According to the calculated combined protection scores, both norfluoxetine and fluoxetine were effective from the concentration of 10 mg/kg,while the highest protective action was observed with clonazepam. Effects of norfluoxetine and fluoxetine on voltage-gated Ca2+ channels were evaluated by measuring peak Ba2+ current flowing through the Ca2+ channels upon depolarization using whole cell voltage clamp in enzymatically isolated rat cochlear neurons. The current was reduced equally in a concentration-dependent manner by norfluoxetine (EC50 = 20.4?2.7M, Hill coefficient = 0.86?0.1) and fluoxetine(EC50 = 22.3?3.6M, Hill coefficient = 0.87?0.1). It was concluded that the efficacy of the two compounds in neuronal tissues was equal, either in preventing seizure activity or in blockingthe neuronal Ca2+ channels.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Fluoxetine Norfluoxetine Anticonvulsants Neuronal Ca2+ currents Voltage clamp
Megjelenés:	Brain Research Bulletin. - 67 : 1-2 (2005), p. 126-132. -
További szerzők:	Rusznák Zoltán (1965-) (élettanász) Riba Pál Pál Balázs (1975-) (élettanász) Wagner Róbert Harasztosi Csaba Nánási Péter Pál (1956-) (élettanász) Szűcs Géza (1948-) (élettanász)
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001-es BibID:	BIBFORM009078
Első szerző:	Lai, Henry H.
Cím:	Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder / Lai, H. H., Smith, C. P., Munoz, A., Boone, T. B., Szigeti, G. P., Somogyi, G. T.
Dátum:	2008
ISSN:	1873-2747 (Electronic)
Megjegyzések:	In the present study, the plasticity of the non-adrenergic non-cholinergic (NANC) response was investigated. Isolated rat bladder strips were electrically stimulated and the evoked contractions were isometrically recorded. The NANC part of the contractions were unmasked by applying 500 nM 4-DAMP, a potent muscarinic antagonist. Treatment of the bladder strips with 10 microM carbachol (a cholinergic agonist) increased the muscle tone but did not alter the neurally evoked contractions. However, carbachol decreased: (1) the NANC response from 74.6% to 33.3% of control and (2) the purinergic contractile response to alpha,beta-methylene ATP (alpha,beta-mATP) (10 microM) from 97.0% to 43.4% (p<0.05). Treatment with the cholinesterase inhibitor eserine (10 microM) also significantly decreased the NANC response to 21.1% (p<0.0001). The purinergic receptor antagonist suramin (100 microM) did not affect the neurally evoked contractions, however; subsequent addition of 4-DAMP decreased the contractions to 31%. Activation of the smooth muscle cholinergic receptors (with carbachol or eserine) and purinergic receptors (with alpha,beta-mATP) decreased the NANC contractions and the direct contractile response to alpha,beta-mATP. When the electrically evoked contractions were facilitated by the L-type Ca2+ channel activator, Bay-K 8644 the subsequent application of 4-DAMP did not unmask inhibited NANC contractions. We conclude that activation of muscarinic receptors by cholinergic agonist, carbachol or by endogenous acetylcholine (ACh) induce a cascade of events that leads to diminished purinergic response and consequently an inhibition of the bladder NANC response.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester Adenosine Triphosphate Animals Antineoplastic Agents Atropine Calcium Channel Agonists Carbachol Cholinergic Agonists Cholinesterase Inhibitors Electric Stimulation Female Muscarinic Antagonists Muscle Contraction Muscle Relaxation Muscle, Smooth Physostigmine Piperidines Rats Rats, Sprague-Dawley Receptors, Cholinergic Suramin Urinary Bladder
Megjelenés:	Brain Research Bulletin. - 77 (2008), p. 420-426. -
További szerzők:	Smith, Christopher P. Munoz, Alvaro Boone, Timothy B. Szigeti Gyula (1969-) (élettanász, elektrofiziológus) Somogyi George T.
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001-es BibID:	BIBFORM001021
Első szerző:	Pocsai Krisztina (élettanász)
Cím:	Rhodamine backfilling and confocal microscopy as a tool for the unambiguous identification of neuronal cell types : a study of the neurones of the rat cochlear nucleus / Pocsai K., Pál B., Pap P., Bakondi G., Kosztka L., Rusznák Z., Szűcs G.
Dátum:	2007
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Brain Research Bulletin. - 71 : 5 (2007), p. 529-539. -
További szerzők:	Pál Balázs (1975-) (élettanász) Pap Pál (1981-) (élettanász) Bakondi Gábor (1980-) (élettanász) Kosztka Lívia (1981-) (élettanász) Rusznák Zoltán (1965-) (élettanász) Szűcs Géza (1948-) (élettanász)
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