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001-es BibID:	BIBFORM004133
Első szerző:	Deli Tamás (szülész-nőgyógyász, endokrinológus szakorvos)
Cím:	Extracellular ATP and cancer : an overview with special reference to P2 purinergic receptors / Tamás Deli, László Csernoch
Dátum:	2008
Megjegyzések:	Purinergic signal transduction mechanisms have been appreciated as a complex intercellular signalling network that plays an important regulatory role in both short- and long-term processes in practically every living cell. One of the most intriguing aspects of the field is the participation of ATP and other purine nucleotides in the determination of cell fate and the way they direct cells towards proliferation, differentiation or apoptosis, thereby possibly taking part in promoting or preventing malignant transformation. In this review, following a very brief introduction to the historical aspects of purinergic signalling and a concise overview of the structure of and signal transduction pathways coupled to P2 purinergic receptors, the current theories concerning the possible ways how extracellular ATP can alter the function of tumour cells and the effectiveness of anticancer therapies are discussed, including pharmacological, nutritional, vasoactive and 'anti-antioxidant' actions of the nucleotide. The effects of ATP on animals inoculated with human tumours and on patients with cancer are looked over next, and then an overview of the literature regarding the expression and presumed functions of P2 purinoceptors on tumour cells in vitro is presented, sorted out according to the relevant special clinical fields. The article is closed by reviewing the latest developments in the diagnostic use of P2 purinergic receptors as tumour markers and prognostic factors, while discussing some of the difficulties and pitfalls of the therapeutic use of ATP analogues.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Pathology and Oncology Research. - 14 : 3 (2008), p. 219-231. -
További szerzők:	Csernoch László (1961-) (élettanász)
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001-es BibID:	BIBFORM068263
035-os BibID:	(WOS)000392307600027 (Scopus)84995753389
Első szerző:	Gaál Zsuzsanna (csecsemő-és gyermekgyógyász központi gyakornok)
Cím:	Expression Levels of Warburg-Effect Related microRNAs Correlate with each Other and that of Histone Deacetylase Enzymes in Adult Hematological Malignancies with Emphasis on Acute Myeloid Leukemia / Gaál Zsuzsanna, Oláh Éva, Rejtő László, Bálint Bálint László, Csernoch László
Dátum:	2017
ISSN:	1219-4956 1532-2807
Megjegyzések:	Disruption of epigenetic regulation and characteristic metabolic alterations (known as the Warburg-effect) are well-known hallmarks of cancer. In our study we investigated the expression levels of microRNAs and histone deacetylase enzymes via RT-qPCR in bone marrow specimens of adult patients suffering from hematological malignancies (total cohort n = 40), especially acute myeloid leukemia (n = 27). The levels of the three examined Warburg-effect related microRNAs (miR-378*, miR-23b, miR-26a) positively correlated with each other and the oncogenic miR-155 and miR-125b, while negatively with the level of the tumorsuppressor miR-124. Significant relationships have been confirmed between the levels of SIRT6, HDAC4 and the microRNAs listed above. In NPM1-mutated AML (n = 6), the level of miR-125b was significantly lower than in the group of AML patients not carrying this mutation (n = 13) (p < 0.05). In M5 FAB type of AML (n = 5), the level of miR-124 was significantly higher compared to the M2 group (n = 7) (p < 0.05). In two cases of FAB M5 AML, the levels of SIRT6 and miR-26a increased during the first 4 weeks of treatment. In the total cohort, white blood cell count at the time of the diagnosis significantly correlated with the levels of HDAC4, SIRT6, miR-124 and miR-26a. Our results suggest that Warburg-effect related microRNAs may have important role in the pathogenesis of leukemia, and the potential oncogenic property of HDAC4 and SIRT6 cannot be excluded in hematological malignancies. Elevated level of miR-125b can contribute to adverse prognosis of AML without NPM1 mutation. The prevailment of the tumorsuppressor property of miR-124 may depend on the accompanying genetic alterations.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Acute myeloid leukemia Anti-oncomiR Histone deacetylase Warburg-effect microRNA oncomiR
Megjelenés:	Pathology & Oncology Research. - 23 : 1 (2017), p. 207-216. -
További szerzők:	Oláh Éva (1943-2019) (gyermekgyógyász, klinikai genetikus) Rejtő László (1963-) (belgyógyász, haematológus) Bálint Bálint László (1971-) (kutató orvos) Csernoch László (1961-) (élettanász)
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001-es BibID:	BIBFORM068259
035-os BibID:	(WOS)000402570200005 (Scopus)84991833276
Első szerző:	Gaál Zsuzsanna (csecsemő-és gyermekgyógyász központi gyakornok)
Cím:	Strong Correlation between the Expression Levels of HDAC4 and SIRT6 in Hematological Malignancies of the Adults / Gaál Zsuzsanna, Oláh Éva, Rejtő László, Erdődi Ferenc, Csernoch László
Dátum:	2017
ISSN:	1219-4956 1532-2807
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Pathology & Oncology Research. - 23 : 3 (2017), p. 493-504. -
További szerzők:	Oláh Éva (1943-2019) (gyermekgyógyász, klinikai genetikus) Rejtő László (1963-) (belgyógyász, haematológus) Erdődi Ferenc (1953-) (biokémikus) Csernoch László (1961-) (élettanász)
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001-es BibID:	BIBFORM077078
035-os BibID:	(Scopus)85061030845 (WOS)000463785500042
Első szerző:	Sipka Sándor (laboratóriumi szakorvos)
Cím:	Season Dependent Changes in the Expression of Protein Kinase C Isoenzymes in a Female Patient with Systemic Lupus Erythematosus / Sándor Sipka, Boglárka Brugós, Gabriella Czifra, Zoltán Griger, Norbert Balogh, Tünde Tarr, Gábor Papp, Tamás Bíró, Margit Zeher
Dátum:	2019
ISSN:	1219-4956 1532-2807
Megjegyzések:	We aimed to answer the question whether the decreased expression of protein kinase C (PKC) isoenzymes in the peripheral blood mononuclear cells (PBMC) of patients with systemic lupus erythematosus (SLE) is inherited or not. For this reason we examined the expression of PKC isoenzymes in a European white girl with acute SLE and in her healthy mother and father simultaneously in summer and winter during one year using western blotting and densitometry. We found that in the father the expression of PKC isoenzymes did not differ from that of eight healthy controls included women and men. However, in the SLE-free mother and in the patient arrived in July with acute symptoms of lupus, the expression of PKC isoenzymes showed a season dependent undulation in parallel. Namely, in summer the expression values were significantly lower, in winter they were significantly higher than those in the controls. Thus, the decreased expression of PKC isoenzymes in the PBMC of SLE patient is not a disease specific marker; it appears also in her lupus free mother. This phenomenon may be due to a season dependent female genetic background. However, the low PKC levels in summer can still decrease further the low production of IL-2 in T cells of lupus patients augmenting the existing AP-1 defects. This is the first report on the season and female dependent inherited changing of PKC expression in a European white patient with SLE and her mother. Further studies are needed to confirm these findings in other populations. European white women Peripheral blood mononuclear cells (PBMC) Protein kinase C (PKC) Season dependence Systemic lupus erythematosus (SLE)
Tárgyszavak:	idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Pathology oncology research. - 25 : 2 (2019), p. 801-805. -
További szerzők:	Brúgós Boglárka (1975-) (belgyógyász) Czifra Gabriella (1975-) (élettanász) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Balogh Norbert (1988-) (molekuláris biológus) Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus) Papp Gábor (1984-) (belgyógyász) Bíró Tamás (1968-) (élettanász) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
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