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001-es BibID:	BIBFORM118718
035-os BibID:	(cikkazonosító)213 (WoS)001152827800001 (Scopus)85187203957
Első szerző:	Singh, Neelam
Cím:	Nanophytosomal gel of Heydotis corymbosa (L.) extract against psoriasis : characterisation, in vitro and in vivo biological activity / Neelam Singh, Ayaz Mukarram Shaikh, Puneet Gupta, Béla Kovács, Mohammed F. Abuzinadah, Aftab Ahmad, Radha Goel, Swapnil Singh, Chaitanya Vinayak
Dátum:	2024
ISSN:	1424-8247
Megjegyzések:	The current study was conducted to examine the possible advantages of Heydotis corymbosa (L.) Lam. extract nanogel as a perspective for enhanced permeation and extended skin deposition in psoriasis-like dermatitis. Optimised nanophytosomes (NPs) were embedded in a pluronic gel base to obtain nanogel and tested ex vivo (skin penetration and dermatokinetics) and in vivo. The optimised NPs had a spherical form and entrapment efficiency of 73.05 ± 1.45% with a nanosized and zeta potential of 86.11 nm and - 10.40 mV, respectively. Structural evaluations confirmed encapsulation of the drug in the NPs. Topical administration of prepared nanogel to a rat model of psoriasis-like dermatitis revealed its specific in vivo anti-psoriatic efficacy in terms of drug activity compared to the control and other formulations. Nanogel had improved skin integrity and downregulation of inflammatory cytokines. These findings suggest that developed phytoconstituent-based nanogel has the potential to alleviate psoriasis-like dermatitis with better skin retention and effectiveness.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Heydotis corymbosa nanogel dermatokinetic psoriasis inflammatory markers skin retention plant derived compounds in vitro and in vivo
Megjelenés:	Pharmaceuticals. - 17 : 2 (2024), p. 1-24. -
További szerzők:	Shaikh, Ayaz Mukarram (1991-) (PhD candidate) Gupta, Puneet Kovács Béla (1963-) (okleveles vegyész, angol szakfordító) Abuzinadah, Mohammed F. Ahmad, Aftab Goel, Radha Singh, Swapnil Vinayak, Chaitanya
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