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001-es BibID:	BIBFORM115804
035-os BibID:	(cikkazonosító)2970 (WoS)001120943600001 (Scopus)85178374983
Első szerző:	Al-Smadi, Mohammad Walid
Cím:	A Microsurgical Arteriovenous Malformation Model on Saphenous Vessels in the Rat / Mohammad Walid Al-Smadi, Laszlo Adam Fazekas, Siran Aslan, Brigitta Bernat, Anas Beqain, Mustafa Qais Muhsin Al-Khafaji, Daniel Priksz, Brigitta Orlik, Norbert Nemeth
Dátum:	2023
ISSN:	2227-9059
Megjegyzések:	Arteriovenous malformation (AVM) is an anomaly of blood vessel formation. Numerous models have been established to understand the nature of AVM. These models have limitations in terms of the diameter of the vessels used and the impact on the circulatory system. Our goal was to establish an AVM model that does not cause prompt and significant hemodynamic and cardiac alterations but is feasible for follow-up of the AVM's progression. Sixteen female rats were randomly divided into sham-operated and AVM groups. In the AVM group, the saphenous vein and artery were interconnected using microsurgical techniques. The animals were followed up for 12 weeks. Anastomosis patency and the structural and hemodynamic changes of the heart were monitored. The hearts and vessels were histologically analyzed. During the follow-up period, shunts remained unobstructed. Systolic, diastolic, mean arterial pressure, and heart rate values slightly and non-significantly decreased in the AVM group. Echocardiogram results indicated minor systolic function impact, with slight and insignificant changes in aortic pressure and blood velocity, and minimal left ventricular wall enlargement. The small-caliber saphenous AVM model does not cause acute hemodynamic changes. Moderate but progressive alterations and venous dilatation confirmed AVM-like features. The model seems to be suitable for studying further the progression, enlargement, or destabilization of AVM.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Biomedicines. - 11 : 11 (2023), p. 1-14. -
További szerzők:	Fazekas László Aslan, Siran Bernát Brigitta (1997-) (farmakológus) Beqain, Anas Al-Khafaji, Mustafa Qais Muhsin Priksz Dániel (1989-) (farmakológus) Orlik Brigitta Németh Norbert (1975-) (kutatóorvos)
Pályázati támogatás:	NKFI-1 "OTKA" K-139184 OTKA UNKP-22-3-I-DE-344 UNKP
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001-es BibID:	BIBFORM102184
035-os BibID:	(cikkazonosító)997 (WOS)000801442800001 (Scopus)85129766302
Első szerző:	Szilágyi Anna Tünde
Cím:	Therapeutic Properties of Ayahuasca Components in Ischemia/Reperfusion Injury of the Eye / Szilágyi Anna, Takács Barbara, Szekeres Réka, Tarjányi Vera, Bombicz Mariann, Priksz Dániel, Kovács Attila, Juhász Béla, Frecska Ede, Szilvássy Zoltán, Varga Balázs
Dátum:	2022
ISSN:	2227-9059
Megjegyzések:	Ischemic eye diseases are major causes of vision impairment. Thus, potential retinoprotective effects of N'N-dimethyltryptamine (DMT) were investigated. To inhibit its rapid breakdown by monoamine-oxidase A (MAO-A) enzyme, DMT was co-administered with harmaline, a -carboline in the Amazonian Ayahuasca brew. Using ligation, 60 min of ischemia was provoked in eyes of rats, followed by 7 days of reperfusion whilst animals received harmaline alone, DMT + harmaline, or vehicle treatment. After 1 week of reperfusion, electroretinographical (ERG) measurements, histological analysis, and Western blot were performed. Harmaline alone exhibited retinoprotection in ischemia?reperfusion (I/R) which was, surprisingly, counterbalanced by DMT in case of co-administration. As both MAO-A inhibition and DMT increase serotoninergic tone synergistically, communicated to be anti-ischemic, thus, involvement of other pathways was investigated. Based on our experiments, DMT and harmaline exert opposite effects on important ocular proteins such as PARP1, NF B, MMP9, or HSP70, each having a critical role in a different mechanism of eye-ischemia-related pathologies, e.g., cell death, inflammation, tissue destruction, and oxidative stress. Since DMT is proclaimed to be a promising drug candidate, its potentially undesirable effect on eye-ischemia should be further investigated. Meanwhile, this experiment revealed the potential therapeutic effect of MAO-A inhibitor harmaline in I/R-related eye diseases.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk DMT harmaline MAO-A inhibition retinal ischemia?reperfusion injury ERG PARP1
Megjelenés:	Biomedicines. - 10 : 5 (2022), p. 1-19. -
További szerzők:	Takács Barbara (1992-) (orvos) Szekeres Réka (1995-) (orvos) Tarjányi Vera (1993-) (orvos) Bombicz Mariann (1987-) (gyógyszerész) Priksz Dániel (1989-) (farmakológus) Kovács Attila István (1968-) (pszichiáter szakorvos) Juhász Béla (1978-) (kísérletes farmakológus) Frecska Ede (1953-) (pszichiáter) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Varga Balázs (1984-) (kísérletes farmakológus)
Pályázati támogatás:	GINOP-2.3.4-15-2020-00008 GINOP GINOP-2.3.3-15-2016-00021 GINOP NKFIH-1150-6/2019 Egyéb TKP2020- NKA-04 Egyéb TKP2020-IKA-04 Egyéb
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