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001-es BibID:	BIBFORM048797
Első szerző:	Czikora Ágnes (molekuláris biológus)
Cím:	Different desensitization patterns for sensory and vascular TRPV1 populations in the rat : expression, localization and functional consequences / Ágnes Czikora, Ibolya Rutkai, Enikő T. Pásztor, Andrea Szalai, Róbert Pórszász, Judit Boczán, István Édes, Zoltán Papp, Attila Tóth
Dátum:	2013
ISSN:	1932-6203
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Plos One. - 8 : 11 (2013), p. 1-8. -
További szerzők:	Rutkai Ibolya (1985-) (molekuláris biológus) Pásztorné Tóth Enikő (1966-) (laboratóriumi analitikus) Szalai Andrea (1968-) (analitikus) Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus) Boczán Judit (1972-) (neurológus) Édes István (1952-) (kardiológus) Papp Zoltán (1965-) (kardiológus, élettanász) Tóth Attila (1971-) (biológus)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0045 TÁMOP K84300 OTKA
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001-es BibID:	BIBFORM059122
035-os BibID:	e0118089
Első szerző:	Kiss Balázs
Cím:	Analysis of the Effect of Locally Applied Inhomogeneous Static Magnetic Field-Exposure on Mouse Ear Edema : a Double Blind Study / Balázs Kiss, János F. László, Andrea Szalai, Róbert Pórszász
Dátum:	2015
ISSN:	1932-6203
Megjegyzések:	The effect static magnetic field (SMF)-exposure may exert on edema development has been investigated. A 6 h long whole-body (WBSMF) or local (LSMF), continuous, inhomogeneous SMF-exposure was applied on anesthetized mice in an in vivo model of mustard oil (MO)-induced ear edema. LSMF was applied below the treated ear, below the lumbar spine, or below the mandible. Ear thickness (v) was checked 8 times during the exposure period (at 0, 0.25, 1, 2, 3, 4, 5, and 6 h). The effect size of the applied treatment (?) on ear thickness was calculated by the formula ? = 100% ? (1?vj/vi), where group i is the control group and j is the treated group. Results showed that MO treatment in itself induced a significant ear edema with an effect of 9% (p<0.001). WBSMF or LSMF on the spine in combination with MO treatment increased ear thickness even further resulting in an effect of ?>11% in both cases compared to SMF-exposure alone (p<0.001). In these cases SMF-exposure alone without MO treatment reduced ear thickness significantly (p<0.05), but within estimated experimental error. In cases of LSMF-exposure on the head, a significant SMF-exposure induced ear thickness reduction was found (? = 5%, p<0.05). LSMF-exposure on the spine affected ear thickness with and without MO treatment almost identically, which provides evidence that the place of local SMF action may be in the lower spinal region.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Edema Magnets Spine Ears Magnetic Fields Histamine Inflammation Rodents
Megjelenés:	Plos One. - 10 : 2 (2015), p. 1-14. -
További szerzők:	László F. János (1956-) (fizikus) Szalai Andrea (1968-) (analitikus) Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus)
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001-es BibID:	BIBFORM072322
035-os BibID:	(cikkazonosító)e0192701 (WOS)000424814300039 (Scopus)85042120858
Első szerző:	Vágási Csongor István
Cím:	Experimental increase in baseline corticosterone level reduces oxidative damage and enhances innate immune response / Csongor I. Vágási, Laura Pătraș, Péter L. Pap, Orsolya Vincze, Cosmin Mureșan, József Németh, Ádám Z. Lendvai
Dátum:	2018
ISSN:	1932-6203
Megjegyzések:	Glucocorticoid (GC) hormones are significant regulators of homeostasis. The physiological effects of GCs critically depend on the time of exposure (short vs. long) as well as on their circulating levels (baseline vs. stress-induced). Previous experiments, in which chronic and high elevation of GC levels was induced, indicate that GCs impair both the activity of the immune system and the oxidative balance. Nonetheless, our knowledge on how mildly elevated GC levels, a situation much more common in nature, might influence homeostasis is limited. Therefore, we studied whether an increase in GC level within the baseline range suppresses or enhances condition (body mass, hematocrit and coccidian infestation) and physiological state (humoral innate immune system activity and oxidative balance). We implanted captive house sparrows Passer domesticus with either 60 days release corticosterone (CORT) or control pellets. CORT-treated birds had elevated baseline CORT levels one week after the implantation, but following this CORT returned to its pre-treatment level and the experimental groups had similar CORT levels one and two months following the implantation. The mass of tail feathers grown during the initial phase of treatment was smaller in treated than in control birds. CORT implantation had a transient negative effect on body mass and hematocrit, but both of these traits resumed the pre-treatment values by one month post-treatment. CORT treatment lowered oxidative damage to lipids (malondialdehyde) and enhanced constitutive innate immunity at one week and one month post-implantation. Our findings suggest that a relatively short-term (i.e. few days) elevation of baseline CORT might have a positive and stimulatory effect on animal physiology.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk antioxidant glucocorticoid stress condition innate immunity oxidative stress
Megjelenés:	Plos One. - 13 : 2 (2018), p. 1-17. -
További szerzők:	Pătraş, Laura Pap Péter László (ökológus) Vincze Orsolya (1988-) (biológus) Mureşan, Cosmin Németh József (1954-) (vegyész, analitikus) Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:	EFOP-3.6.2-16-2017-00009 EFOP OTKA K 113108 OTKA EFOP-3.6.1-16-2016-00022 EFOP PD-76862 OTKA
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