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1.

001-es BibID:BIBFORM038800
035-os BibID:PMID:16092549
Első szerző:Borkó Rezső
Cím:Electromotile performance of isolated outer hair cells during slow motile shortening / Rezső Borkó, Tamás József Batta, István Sziklai
Dátum:2005
ISSN:0001-6489
Megjegyzések:The electromotile performance of isolated OHCs does not seem to be dependent on slow motile shortening alone; other mechanisms, such as phosphorylation, are also involved. OBJECTIVE: To elucidate the relationship between the magnitude of electromotile displacements and magnitude of slow motile shortening of outer hair cells (OHCs) induced by mechanical or chemical stimulation over a reversible range. MATERIAL AND METHODS: Isolated guinea pig OHCs were mechanically (0.6 microl/min perfusion of saline; n =4) or chemically and mechanically (0.6 microl/min perfusion of 12.5 mM KCl; n =4) stimulated in a glass microchamber to evoke slow motile shortening. RESULTS: Combined mechanical and chemical stimulation evoked greater OHC shortening than mechanical stimulation alone. Both forms of stimulation resulted in reversible shortening. Electromotility was measured using low voltage (+/- 35 mV) and higher voltage (up to +/- 240 mV) electrical pulses mimicking the receptor potential at different stages of cell shortening. The magnitude of electromotility decreased simultaneously with slow motile shortenings of OHCs. Irrespective of the character of the stimulus (mechanical or mechanical + chemical), the decrease in the magnitude of electromotility was dependent on the degree of cell shortening. Ocadaic acid, a protein phosphatase inhibitor, blocked slow motility and decreased the magnitude of electromotility.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Oto-Laryngologica. - 125 : 5 (2005), p. 547-551. -
További szerzők:Batta József Tamás (1970-) (fül-orr-gégész) Sziklai István (1954-) (fül-orr-gégész)
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2.

001-es BibID:BIBFORM033110
035-os BibID:PMID:22385409
Első szerző:Csomor Péter (biotechnológus)
Cím:Expression of bone morphogenetic protein 2, 4, 5, and 7 correlates with histological activity of otosclerotic foci / Péter Csomor, Balázs Liktor, Bálint Liktor, Zoltán Szekanecz, István Sziklai, Tamás Karosi
Dátum:2012
ISSN:0001-6489
Megjegyzések:Abstract Conclusion: This study is the first to establish that bone morphogenetic protein 5 (BMP5) plays a role in the pathogenesis of otosclerosis. These results confirm that elevated expression levels of BMPs, members of the transforming growth factor (TGF)-? superfamily, contribute to the pathologically increased bone turnover in early, active stages of otosclerosis. Objectives: Otosclerosis is a complex bone remodeling disorder of the otic capsule, which might be characterized by increased expression of different types of BMPs. TGF-? and BMP are both members of the TGF-? superfamily and play a critical role in bone resorption and new bone formation. It has been suggested that BMP and its receptors may be involved in the pathologically increased bone turnover observed in otosclerosis. Methods: Fifty-one otosclerotic and 16 non-otosclerotic ankylotic stapes footplates were histologically analyzed: conventional hematoxylin-eosin staining and BMP2, 4, 5, and 7specific immunofluorescent assays were performed. Cortical bone fragments (n = 35) and incus specimens (n = 6) were used as negative controls. Results: Active otosclerosis (n = 39) was characterized by increased expression of BMP2, 4, 5, and 7. Inactive cases of otosclerosis (n = 12) were characterized by negative immunoreaction for BMPs. Non-otosclerotic stapes specimens (n = 16) and negative controls (n = 41) showed negligible BMP expression. The BMP expression pattern showed a strong correlation with the histological activity of otosclerosis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Bone remodelling disorder
non-otosclerotic stapes fixation
stapes
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Oto-Laryngologica. - 132 : 6 (2012), p. 624-631. -
További szerzők:Liktor Balázs (1984-) Liktor Bálint Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Sziklai István (1954-) (fül-orr-gégész) Karosi Tamás (1979-) (fül-orr-gégész)
Pályázati támogatás:PD75371
OTKA
K81480
OTKA
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DOI
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3.

001-es BibID:bibEBI13784
Első szerző:Farkas Zsolt (fül-orr-gégész)
Cím:Potassium-induced slow motility is partially calcium-dependent in isolated outer hair cells / Farkas, Zs., Sziklai, I.
Dátum:2003
Megjegyzések:Low flow rate (0.6 microl/min) administration of high concentration potassium solutions (12.5, 25 and 37.5 mM) was tested for evoking slow-motility length changes in isolated, apical turn, guinea pig outer hair cells (OHCs) (length 65-80 microm; n = 38). Control OHCs (n = 16) showed a flow rate-dependent, reversible, longitudinal shortening of 0.5-3 microm during perfusion with normal saline. Potassium, an effective depolarizing agent for OHCs, induced a concentration-dependent cell shortening of 0.5-13 microm. These cell shape changes were reversible. The magnitude of shortening was significantly (p < 0.01) decreased in a calcium-free incubation medium (n = 8). The velocity of the shortening was 300 nm/s in the first 10 s after application of 37.5 mM K+ in a normal incubation medium and decreased to 100 nm/s during the next 10 s. Corresponding velocities in calcium-free solutions were 100 and 50 nm/s, respectively. K+-induced shortening velocities were not significantly different from control values after 30 s. It appears that K+-induced OHC shortening is sensitive to the calcium content of the incubation medium during the first 10 s. Higher flow rate (1.5 microl/min) administration of K+ makes the velocity and magnitude of slow motility of OHCs insensitive to the absence of calcium. These results highlight the fact that one of the critical technical points in fluid perfusion experiments with isolated OHCs is selecting a safe low flow rate of < 0.6 microl/min. At this perfusion rate, K+-induced OHC shortening is composed of both calcium-sensitive and -insensitive components.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Oto-Laryngologica. - 123 : 2 (2003), p. 160-163. -
További szerzők:Sziklai István (1954-) (fül-orr-gégész)
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4.

001-es BibID:BIBFORM040085
Első szerző:Sziklai István (fül-orr-gégész)
Cím:Phosphorylation Mediates the Influence of Acetylcholine upon Outer Hair Cell Electromotility / Sziklai, I., Szőnyi, M., Dallos, P.
Dátum:2001
ISSN:0001-6489
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Oto-Laryngologica. - 121 : 2 (2001), p. 153-156. -
További szerzők:Szőnyi Magdolna Dallos Péter
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5.

001-es BibID:BIBFORM024629
Első szerző:Sziklai István (fül-orr-gégész)
Cím:Functional gain and speech understanding obtained by Vibrant Soundbridge or by open-fit hearing aid / Sziklai I., Szilvássy J.
Dátum:2011
Megjegyzések:There is no significant difference in speech recognition scores obtained with the Vibrant Soundbridge and the open-fit hearing aid. However, the Vibrant Soundbridge may be superior to open-fit hearing aids in improving hearing at high frequencies (4-8 kHz). OBJECTIVES: To assess whether an improvement in speech recognition conferred by Vibrant Soundbridge is more marked than that afforded by open-fit hearing aids in patients with sloping high frequency sensorineural hearing loss (SNHL). METHODS: This study had a self-control prospective design. Seven patients aged 21-62 years with sloping high frequency SNHL were recruited into the study. Each patient received a Vibrant Soundbridge middle ear implant (Vibrant MED-EL) and wore an open-fit hearing aid (Danavox, DOT 10). Speech recognition tests were performed according to protocols suggested by árpád Götze's speech definition test in Hungarian language. In the first session, conventional hearing thresholds (unaided pure tone thresholds) were measured. In the second session, the aided sound-field threshold, speech understanding score and functional gain obtained using middle ear implants and open-fit hearing aids were determined after programming of the devices. RESULTS: Regarding speech recognition scores, there were no significant differences between data obtained with the middle ear implant and those with the open-fit hearing aid.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Oto-Laryngologica. - 131 : 4 (2011), p. 428-433. -
További szerzők:Szilvássy Judit (1960-2022) (fül- orr- gégész)
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6.

001-es BibID:BIBFORM045517
Első szerző:Szőnyi Magdolna
Cím:Acetylcholine-induced phosphorlylation in isolated outer hair cells / Szőnyi, M., Csermely, P., Sziklai, I.
Dátum:1999
ISSN:0001-6489
Megjegyzések:Two groups of isolated, surviving outer hair cells (OHCs) of guinea pig cochleas (n = 20, for each group) were treated with 10 microM acetylcholine or acetylcholine plus strichnine (an alpha9 nAChR antagonist), respectively, under short-term tissue culture conditions. The protein content of the cell homogenates was separated by SDS-polyacrylamide gel electrophoresis, Western blotted and labelled with an antibody against phosphoserine residues. Signals were detected using the ECL system. Acetylcholine challenge of the OHCs resulted in a difference in the pattern of phosphorylated proteins from those of strichnine pretreated cells. A 220 kDa and a 120 kDa protein expressed a more intense phosphorylated state in the ACh group compared with the ACh plus strichnine group. The 220 kDa phosphoprotein is in the range of the cytoskeletal protein beta-fodrin, whereas the 120 kDa fraction is similar to alpha-fodrin or an ankyrin isoform. Phosphorylation of proteins due to activation of the AChR by agonist can play a role in the signalling mechanism between receptor activation and increase in the electromotile capability of isolated OHCs.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Oto-Laryngologica. - 119 : 2 (1999), p. 185-188. -
További szerzők:Csermely Péter Sziklai István (1954-) (fül-orr-gégész)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM030082
Első szerző:Tóth László (fül-orr-gégész)
Cím:Electronystagmographic analysis of optokinetic nystagmus for the evaluation of ocular symptoms in myasthenia gravis / László Tóth, Ágnes Tóth, Péter Diószeghy, Gábor Répássy
Dátum:1999
Megjegyzések:Ocular symptoms of 17 myasthenia gravis (MG) patients were examined by electronystagmographic registration of optokinetic nystagmus. The aim of this study was to replace the subjective methods used previously with a more reliable quantitative technique and thus assess ophthalmoplegia and diplopia, important initial symptoms in MG. Slow phase angular speed values of foveolar type optokinetic nystagmus in the horizontal plane at 10, 20 and 30 degrees/s target speed were determined. Measurements were performed before and after administration of Mestinon, a reversible cholinesterase inhibitor. Twelve healthy volunteers were examined as controls under standard conditions. Results showed significant differences between MG patients and control group. Slow-phase angular speed was significantly larger after Mestinon administration (p < 0.001). It is concluded, that the exhaustion of external ocular muscles in MG can be well characterized by the determination of the slow phase angular speed values of optokinetic nystagmus (OKN). The examination of OKN was also recommended for the evaluation of ocular symptoms in other neurological disorders.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Otolaryngologica. - 119 : 6 (1999), p. 629-632. -
További szerzők:Tóth Ágnes (1949-) (fül-orr-gégész) Diószeghy Péter (1948-) (ideg- és elmeszakorvos) Répássy Gábor (1947-) (fül-orr-gégész)
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