CCL

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1.

001-es BibID:BIBFORM038801
035-os BibID:PMID:15950414
Első szerző:Borkó Rezső
Cím:Slow motility, electromotility and lateral wall stiffness in the isolated outer hair cells / Rezső Borkó, Tamás József Batta, István Sziklai
Dátum:2005
ISSN:0378-5955
Megjegyzések:Slow motile length changes of isolated, apical turn outer hair cells (OHCs) (n=36) were induced by perfusion of saline (flow rate: 0.6 microl/min) as a mechanical challenge or by perfusion of 12.5 mM KCl solution for 90 s as a chemical and mechanical challenge with and without ocadaic acid (OA), a serine/threonine protein phosphatase inhibitor. Electromotility was evoked by square pulses from +/-35 mV to +/-240 mV during the slow shortening and recovery period (n=36). Stiffness of the lateral wall was measured by the micropipette aspiration technique (n=20). Saline perfusion caused a reversible shortening of 774+/-87 nm (n=9) as well as K+ of 1465+/-159 nm (n=9). Slow shortening increased lateral wall stiffness (1.25+/-0.02 to 1.52+/-0.03 nN/microm) (n=5-5). Simultaneously, electromotility magnitude decreased (n=9). Ocadaic acid blocked slow shortening, increased lateral wall stiffness, and decreased the magnitude of electromotility. Mechanical or mechanical+chemical stimulation of ocadaic acid treated OHCs do not further change stiffness or electromotility. Isolated OHCs respond with slow shortening and consutive cell stiffness increase to mechanical insult. This phenomenon seems operating with calcium-, and phosphorylation-dependent modifications of the cytoskeletal proteins. The subsequent electromotility gain decrease suggests a slow OHC shortening driven regulation of the cochlear amplifier with simultaneous safety control of the auditory periphery against overstimulation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Hearing Research. - 207 : 1-2 (2005), p. 68-75. -
További szerzők:Batta József Tamás (1970-) (fül-orr-gégész) Sziklai István (1954-) (fül-orr-gégész)
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2.

001-es BibID:BIBFORM055376
Első szerző:Jókay István (fül-orr-gégész)
Cím:Apoptosis in the human inner ear : Detection by in situ end-labeling of fragmented DNA and correlation with other markers / István Jókay, Györgyike Soós, Gábor Répássy, Balázs Dezső
Dátum:1998
ISSN:0378-5955
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Hearing Research. - 117 : 1-2 (1998), p. 131-139. -
További szerzők:Soós Györgyike (1959-) (pathológus) Répássy Gábor (1947-) (fül-orr-gégész) Dezső Balázs (1951-) (pathológus)
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3.

001-es BibID:BIBFORM040765
Első szerző:Szőnyi Magdolna
Cím:Cyclic GMP and outer hair cell electromotility / Szönyi Magdolna, He David Z. Z., Ribári Ottó, Sziklai István, Dallos Peter
Dátum:1999
ISSN:0378-5955
Megjegyzések:The aim of this study is to examine the effect of phosphorylation pathways on the electrically evoked fast motile response of isolated outer hair cells (OHCs). Transcellular electrical stimulation was applied in the microchamber to guinea pig OHCs and motility was measured before and after drug application. Forskolin (adenylate cyclase activator), phorbol 12-myristate 13-acetate (PMA, protein kinase C activator) and dibutyryl 3',5'-cyclic guanosine monophosphate (cGMP agonist) were studied. As controls, L15 medium and dimethyl-sulfoxide (DMSO) were used. In each group, 12 cells were measured. Forskolin and PMA were dissolved in 0.1% DMSO to render them membrane permeable. DMSO by itself caused a statistically significant electromotility magnitude decrease. Forskolin and PMA could not reverse the motility decrease due to DMSO, the effects seen in their presence were the same as observed with DMSO alone. Thus, neither 3',5'-cyclic AMP-dependent protein kinase nor calcium/phospholipid-dependent protein kinase appear to have modulatory effects on electromotility. Dibutyryl cGMP (DBcGMP), in concentrations of 200 microM, elicited a significant electromotility magnitude increase. The DBcGMP effect could be inhibited by co-application of 200 microM DBcGMP and 100 microM 8-Rp-pCPT-cGMPS (8-4-chlorophenylthio-guanosine 3',5'-cyclic monophosphothioate, Rp isomer, a cGMP antagonist). Our results suggest that OHC electromotility is modulated by a cGMP-dependent pathway.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Hearing Research. - 137 : 1-2 (1999), p. 29-42. -
További szerzők:He, David Z. Z. Ribári Ottó (1932-) (fül-orr-gégész, audiológus) Sziklai István (1954-) (fül-orr-gégész) Dallos Péter
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4.

001-es BibID:BIBFORM004847
Első szerző:Szűcs Attila (fül-orr-gégész)
Cím:Differential expression of purinergic receptor subtypes in the outer hair cells of the guinea pig / Attila Szücs, Henrietta Szappanos, Andrea Tóth, Zsolt Farkas, György Panyi, László Csernoch, István Sziklai
Dátum:2004
Megjegyzések:ATP acts as a neuro-modulator through purinoceptors in many different tissues. Many subtypes of these receptors have been identified in the inner ear, but so far only two types have been shown to be present in the membrane of the isolated outer hair cells (OHCs). The aim of this study was to detect and visualize the existence and distribution of purinoceptor subtypes as well as to study the [Ca(2+)](i) response of these cells in response to stimulation with ATP. Four P2X and three P2Y receptor subtypes were identified with different expression pattern in the membrane of guinea pig outer hair cells. Whereas intense labeling was observed for P2X1, P2X2, P2X4, P2Y1, P2Y2, and P2Y4, the labeling for the subtype P2X7 was weak. There was a marked difference in the distribution of the receptors along the surface of the cells with a homogenous distribution in cases of P2X1, P2X4, and P2Y1. In contrast, P2X2 and P2Y2 receptor density was high mainly at the apical, while P2X7 and P2Y4 at the basal pole of the cells. Similarly a heterogeneity was observed in the ATP-induced transient elevation in [Ca(2+)](i), which had either fast kinetics without desensitization or slow rise with desensitization.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Calcium
Cells
Female
Guinea Pigs
Hair Cells,Outer
Hungary
Immunohistochemistry
Kinetics
Male
metabolism
Microscopy, Fluorescence
Receptors, Purinergic P2
Research
Support
Tissue Distribution
Megjelenés:Hearing Research. - 196 : 1-2 (2004), p. 2-7. -
További szerzők:Szappanos Henrietta (1976-) (biológus, élettanász) Tóth Andrea (1973-) (fül-orr-gégész) Farkas Zsolt (1969-) (fül-orr-gégész) Panyi György (1966-) (biofizikus) Csernoch László (1961-) (élettanász) Sziklai István (1954-) (fül-orr-gégész)
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5.

001-es BibID:BIBFORM030057
Első szerző:Tóth László (fül-orr-gégész)
Cím:Otoacoustic emission in myasthenia gravis patients and the role of efferent activation / László Tóth, Tamás Rácz, Péter Diószeghy, Gábor Répássy, István Lampé
Dátum:1998
ISSN:0378-5955
Megjegyzések:We performed transient evoked otoacoustic emission (TEOAE) measurements on 29 ears of myasthenia gravis (MG) patients. The purpose of the study was to support the role of acetylcholine (ACh) in the efferent innervation of cochlear outer hair cells (OHCs). Another aim was to establish additional diagnostic tools for the early determination of MG. Initially, threshold audiometry and impedance measurements showed normal values on the ears examined. The main finding was that TEOAE values were significantly lower in MG patients than in healthy controls. Mestinon, a reversible cholinesterase inhibitor, resulted in a significant increase in mean values of TEOAEs, although these values were still lower than normal. The results suggest that in MG, acetylcholine receptor (AChR) autoantibodies inhibit the function of OHC AChRs. Thus, the TEOAE generated by the active movements of OHCs is decreased in MG. Mestinon prevents the degradation of ACh, and thus stimulates efferent function and increases TEOAE values. The results obtained in this study support the role of ACh in the efferent function of OHC, as well as the impaired function of hair cell AChRs in MG patients. Consequently, measuring TEOAEs may be useful in the early diagnosis of some forms of MG. These results reinforce the importance of collaboration between neurologists and otolaryngologists in the management of diseases with pathological neurotransmission.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Hearing Research. - 126 : 1-2 (1998), p. 123-125. -
További szerzők:Rácz Tamás (1961-) (fül-orr-gégész) Diószeghy Péter (1948-) (ideg- és elmeszakorvos) Répássy Gábor (1947-) (fül-orr-gégész) Lampé István (1932-) (fül-orr-gégész, audiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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