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001-es BibID:	BIBFORM024608
Első szerző:	Rezes Szilárd (fül-orr-gégész)
Cím:	Human bocavirus and rhino-enteroviruses in childhood otitis media with effusion / Rezes S., Söderlund-Venermo M., Roivainen M., Kemppainen K., Szabó Z., Sziklai I., Pitkäranta A.
Dátum:	2009
Megjegyzések:	Viral respiratory infections play an important role in the pathogenesis of otitis media with effusion (OME) in children. The most common human rhinoviruses (HRVs) have been detected in middle ear effusions (MEE), but there is only limited data available about the closely related human enteroviruses (HEVs). The newly discovered human bocavirus (HBoV) has not, however, been identified in MEE of OME children. OBJECTIVES: The aim of our study was to determine the presence of HBoV and HRV/HEV and the rate of coinfection in a set of MEE samples collected from OME children. STUDY DESIGN: Seventy-five MEE samples from 54 children with no acute respiratory symptoms were studied with reverse transcription polymerase chain reaction (RT-PCR) for detection of HRV/HEV and quantitative PCR for detection of HBoV. RESULTS: Twenty-six (35%) of 75 MEE samples were positive for viral nucleic acid, 22 (29%) for HEV, 10 (13%) for HRV and 2 (3%) for HBoV. There was no statistically significant difference between mucoid and serous effusions in the rate of virus detection. Forty-three percent of bilateral cases showed a contra-lateral difference in viral finding. CONCLUSIONS: Our results suggest that these common respiratory viruses can be associated with OME in children. Whether these viruses are causative etiologic factors of MEE persistence or merely remnants of previous infections is not known.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Clinical Virology. - 46 : 3 (2009), p. 234-237. -
További szerzők:	Söderlund-Venermo, Maria Roivainen, Merja Kemppainen, Kaisa Szabo Zsolt Sziklai István (1954-) (fül-orr-gégész) Pitkäranta, Anne
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM042471
035-os BibID:	(Scopus)84874589132 (WOS)000316757300001
Első szerző:	Szalmás Anita (biológus, mikrobiológus, klinikai mikrobiológus)
Cím:	Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein / Anita Szalmás, Eszter Gyöngyösi, Annamária Ferenczi, Brigitta László, Tamás Karosi, Péter Csomor, Lajos Gergely, György Veress, József Kónya
Dátum:	2013
ISSN:	1743-422X
Megjegyzések:	BackgroundThe Src family tyrosine kinases (SFK) are cellular regulatory proteins that influence cell adhesion, proliferation, invasion and survival during tumor development. Elevated activity of Src was associated with increased cell proliferation and invasivity in human papillomavirus (HPV)-associated malignancies; therefore, transduced human foreskin keratinocytes (HFK) were used to investigate whether SFK activation is a downstream effect of papillomaviral oncoproteins. Activation of ubiquitously expressed SFKs, namely Src, Yes and Fyn, was investigated in both proliferating and differentiating keratinocytes.ResultsIn proliferating keratinocytes, Src, Yes and Fyn mRNA levels were not affected by HPV 16 E6 or E7 oncoproteins, while at the protein level as detected by western blot, the presence of both E6 and E7 resulted in substantial increase in Src and Yes expression, but did not alter the high constitutive level of Fyn. Phospo-kinase array revealed that all ubiquitously expressed SFKs are activated by phosphorylation in the presence of HPV 16 E7 oncoprotein. Keratinocyte differentiation led to increased Yes mRNA and protein levels in all transduced cell lines, while it did not influence the Src transcription but resulted in elevated Src protein level in HPV16 E7 expressing lines.ConclusionsThis study revealed that HPV 16 oncoproteins upregulate Src family kinases Src and Yes via posttranscriptional mechanisms. A further effect of HPV 16 E7 oncoprotein is to enhance the activating phosphorylation of SFKs expressed in keratinocytes.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Open Access egyetemen (Magyarországon) készült közlemény
Megjelenés:	Virology Journal. - 10 : 1 (2013), p. 79. -
További szerzők:	Gyöngyösi Eszter (1983-) (molekuláris biológus, mikrobiológus) Ferenczi Annamária (1986-) (molekuláris biológus, mikrobiológus) László Brigitta (1983-) (molekuláris biológus, mikrobiológus) Karosi Tamás (1979-) (fül-orr-gégész) Csomor Péter (1984-) (biotechnológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Veress György (1966-) (biológus, mikrobiológus) Kónya József (1964-) (szakorvos, klinikai mikrobiológus)
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