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001-es BibID:	BIBFORM024484
Első szerző:	Kozma László (orvos)
Cím:	C-myc amplification and cluster analysis in human gastric carcinoma / László Kozma, István Kiss, Jenő Hajdú, Zsolt Szentkereszty, Szabolcs Szakáll, István Ember
Dátum:	2001
ISSN:	0250-7005
Megjegyzések:	The tumour samples ot 23 patients (9 male, 14 female, aged 28-85) were randomly selected for the study. DNA was isolated from paraffin embedded tissue for quantitative dot-blot hybridization, in order to determine the amplification values for the c-myc and K-ras oncogenes. The clinical and histological parameters studied were as follows: grade, TNM staging system, Lauren's histological type, localization and the severity of the disease. Amplified c-myc was found in 6 cases. Amplification was concomitant with c-myc overexpression detected with immunohistochemical staining. The amplification--9.1-fold on the average (ranging from 2.12 to 18.2) was significantly associated with the presence of distant metastasis (corr. coeff.: 0.5623, p < 0.01), but with none of the other parameters. No case with K-ras amplification was recorded. The result of the multivariate cluster analysis proved that age was the decisive factor in the segregation process. This age-related distribution (69 vs. 40, p < 0.001), however, did not coincide with either the incidence of distant metastasis or c-myc amplification.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Anticancer Research. - 21 : 1B (2001), p. 707-710. -
További szerzők:	Kiss István (Pécs) Hajdu Jenő Szentkereszty Zsolt (1961-) (sebész) Szakáll Szabolcs Ember István
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM024680
Első szerző:	Nagy András (pathológus)
Cím:	Copy number of cancer genes predict tumor grade and survival of pancreatic cancer patients / Andras Nagy, Laszlo Kozma, Istvan Kiss, Istvan Ember, Istvan Takacs, Jeno Hajdu, Nadir R. Farid
Dátum:	2001
ISSN:	0250-7005
Megjegyzések:	Pancreatic cancer is on the increase. While means of early diagnosis are being sought, it continues to present late. Prognostication is based on patient and tumor characteristics, including expression or mutation of cancer-related genes. Few studies have examined the impact of the amplification of these genes on the outcome of pancreatic cancer. We have now used a non-radioisotopic slot-blot technique to relate gene copy numbers of p53, c-myc and K-ras to tumor grade and survival. Outcomes were corrected for patient characteristics, tumor location and TNM staging. The Kaplan-Meier test for likelihood of survival showed that increase in copy number of the two oncogenes and loss of p53 were associated with non-significant reduction in survival. When these variations in cancer gene copy numbers were, however, examined by logistic regression analysis in the context of patient and tumor characteristics, survival was negatively related to K-ras amplification (p = 0.0291). Tumor grade, but not survival was positively related to loss of p53 gene copy (p = 0.0131) as well as c-myc amplification (p = 0.0248). Thus using a simple non-radioisotopic technique for the detection of cancer gene copy number in association with patients and disease characteristics, we could predict survival on the one hand and tumor behavior on the other. Such information could be used to plan initial and follow-up therapy.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Anticancer Research. - 21 : 2B (2001), p. 1321-1325. -
További szerzők:	Kozma László (orvos) Kiss István (Pécs) Ember István Takács István (1963-) (sebész) Hajdu Jenő Farid, Nadir R.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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