CCL

Összesen 10 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM057430
Első szerző:Auricchio, Renata
Cím:The frequency of coeliac disease (CD) in high-risk young children from families with CD : the Preventcd cohort / R. Auricchio, C. Hogen Esch, G. Castillejo, E. Mummert, E. Bravi, I. Korponay-Szabo, S. Koletzko, L. Greco, R. Troncone, M. L. Mearin, The PreventCD Study Group
Dátum:2011
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Journal of Pediatric Gastroenterology and Nutrition 52 : Suppl. 2 (2011), p. E7. -
További szerzők:Hogen Esch, Caroline Castillejo, Gemma (gyermekgyógyász, gasztroenterológus) Mummert, Eckart Bravi, Enzo (biológus) Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Koletzko, Sibylle Greco, Luigi Troncone, Riccardo Mearin, Maria Luisa the PREVENTCD Study Group
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM044267
Első szerző:Giersiepen, Klaus
Cím:Accuracy of Diagnostic Antibody Tests for Coeliac Disease in Children / Giersiepen Klaus, Lelgemann Monika, Stuhldreher Nina, Ronfani Luca, Husby Steffen, Koletzko Sibylle, Korponay-Szabó Ilma R., the ESPGHAN Working Group on Coeliac Disease Diagnosis
Dátum:2012
ISSN:0277-2116
Megjegyzések:OBJECTIVE: The aim of this study was to summarise the evidence from 2004 toSeptember 2009 on the performance of laboratory-based serological and point ofcare (POC) tests for diagnosing coeliac disease (CD) in children using histology as reference standard.PATIENTS AND METHODS: We searched MEDLINE and EMBASE for studies reporting onchildren for tests based on IgA and IgG anti-gliadin (AGA), endomysial (EmA),anti-transglutaminase-2 (TG2), and anti-deamidated gliadin peptides (DGP)antibodies or POC tests. For inclusion, histological analysis of duodenalbiopsies and sensitivity and specificity for index tests had to be reported. Datawere pooled and summary measures calculated for sensitivity, specificity,positive and negative likelihood ratios ("LR+", "LR-"), and diagnostic oddsratios (DOR). In case of elevated statistical heterogeneity, studies reaching 90%sensitivity or specificity were reported.RESULTS: A total of 2510 articles were reviewed; 16 entered meta-analysis,reporting on 3110 patients (1876 with CD, 1234 without CD). For IgA-EmA,sensitivity was ?90% in 7/11 studies and pooled specificity 98.2%. ForIgA-anti-TG2, 11/15 studies yielded sensitivities ?90% and 13/15 specificities?90%. For IgA-DGP, sensitivity ranged between 80.7% and 95.1% (specificity86.3%-93.1%); for IgG-DGP between 80.1% and 98.6% (specificity 86.0-96.9%).IgA-EmA had the highest pooled DOR (554) and LR+ (31.8) for a laboratory test,followed by IgA-anti-TG2, IgG-DGP, IgA-DGP and IgA-AGA. POC tests showed a pooledsensitivity of 96.4% for IgA-TG2 (specificity 97.7%).CONCLUSIONS: IgA-EmA and IgA-anti-TG2 tests appear highly accurate to diagnoseCD. IgG-anti-DGP tests may help in excluding CD. IgA-AGA and IgA-DGP tests showinferior accuracy. POC tests may achieve high accuracy in the hands ofexperienced readers, but IgA-anti-TG2/EmA were superior.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition. - 54 : 2 (2012), p. 229-241. -
További szerzők:Lelgemann, Monika Stuhldreher, Nina Ronfani, Luca Husby, Steffen Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) the ESPGHAN Working Group on Coeliac Disease Diagnosis
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM044266
Első szerző:Husby, Steffen
Cím:European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease / Husby, S., Koletzko, S., Korponay-Szabó, I. R., Mearin, M. L., Phillips, A., Shamir, R., Troncone, R., Giersiepen, K., Branski, D., Catassi, C., Lelgeman, M., Mäki, M., Ribes-Koninckx, C., Ventura, A., Zimmer, K. P., the ESPGHAN Working Group on Coeliac Disease Diagnosis, the ESPGHAN Gastroenterology Committee
Dátum:2012
ISSN:0277-2116
Megjegyzések:OBJECTIVE: Diagnostic criteria for coeliac disease (CD) from the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) were published in 1990. Since then, the autoantigen in CD, tissue transglutaminase, has been identified; the perception of CD has changed from that of a rather uncommon enteropathy to a common multiorgan disease strongly dependent on the haplotypes human leukocyte antigen (HLA)-DQ2 and HLA-DQ8; and CD-specific antibody tests have improved.METHODS:A panel of 17 experts defined CD and developed new diagnostic criteria based on the Delphi process. Two groups of patients were defined with different diagnostic approaches to diagnose CD: children with symptoms suggestive of CD (group 1) and asymptomatic children at increased risk for CD (group 2). The 2004 National Institutes of Health/Agency for Healthcare Research and Quality report and a systematic literature search on antibody tests for CD in paediatric patients covering the years 2004 to 2009 was the basis for the evidence-based recommendations on CD-specific antibody testing.RESULTS:In group 1, the diagnosis of CD is based on symptoms, positive serology, and histology that is consistent with CD. If immunoglobulin A anti-tissue transglutaminase type 2 antibody titers are high (>10 times the upper limit of normal), then the option is to diagnose CD without duodenal biopsies by applying a strict protocol with further laboratory tests. In group 2, the diagnosis of CD is based on positive serology and histology. HLA-DQ2 and HLA-DQ8 testing is valuable because CD is unlikely if both haplotypes are negative.CONCLUSIONS:The aim of the new guidelines was to achieve a high diagnostic accuracy and to reduce the burden for patients and their families. The performance of these guidelines in clinical practice should be evaluated prospectively.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
celiac disease
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition 54 : 1 (2012), p. 136-160. -
További szerzők:Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Mearin, Maria Luisa Phillips, A. Shamir, R. Troncone, Riccardo Giersiepen, Klaus Branski, D. Catassi, Carlo Lelgemann, Monika Mäki, Markku Ribes-Koninckx, Carmen Ventura, Alessandro Zimmer, Klaus-Peter the ESPGHAN Working Group on Coeliac Disease Diagnosis the ESPGHAN Gastroenterology Committee
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM057431
Első szerző:Korponay-Szabó Ilma (gyermekgyógyász)
Cím:Development and validation of a simple diagnostic score for coeliac disease (SAGE) based on symptoms, antibodies, HLA genotypes and biopsy results / I. Korponay-Szabo, J. Gyimesi, J. Tumpek, E. Nemes, M. Mäki, J. B. Kovacs
Dátum:2011
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Journal of Pediatric Gastroenterology and Nutrition. - 52 : Suppl. 2 (2011), p. E35. -
További szerzők:Gyimesi Judit Tumpek Judit (1944-) (orvosi laboratóriumi szakorvos) Nemes Éva (1957-) (csecsemő- és gyermekgyógyász, gasztroenterológus) Mäki, Markku B. Kovács Judit
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM056542
Első szerző:Korponay-Szabó Ilma (gyermekgyógyász)
Cím:Autoantibodies and CD : past and future of celiac antibody testing / Ilma R. Korponay-Szabó
Dátum:2014
ISSN:0277-2116
Megjegyzések:Celiac disease (CD) is triggered by the consumption of gluten-containing cereals to which patients mount a T-lymphocyte and antibody response in both immunoglobulin A and immunoglobulin G classes coupled with autoantibody production against self-proteins, predominantly type-2 (tissue) transglutaminase (TG2). TG2 autoantibodies are biologically active and bind to their target protein in the patients' tissues, including the gut and extraintestinal tissues. This peculiar systemic anti-TG2 reaction is dependent on the presence of dietary gluten and stops after its elimination. As both anti-TG2 and anti-gliadin antibodies are activity markers, their detection is valuable for the disease recognition and therapy monitoring. High concentrations of serum anti-TG2 antibody positivity supported by highly specific positivity for endomysial antibodies became the critical component of celiac JPGN Volume 59, Supplement 1, July 2014 Celiac Disease: Past, Present, Future Challenges www.jpgn.org S11
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition 59 : Suppl. 1 (2014), p. S11-S13. -
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM044281
Első szerző:Koskinen, Outi
Cím:Gluten-dependent small bowel mucosal transglutaminase 2-specific IgA deposits in overt and mild enteropathy coeliac disease / Koskinen Outi, Collin Pekka, Korponay-Szabo Ilma, Salmi Teea, Iltanen Sari, Haimila Katri, Partanen Jukka, Mäki Markku, Kaukinen Katri
Dátum:2008
ISSN:0277-2116
Megjegyzések:OBJECTIVES: In coeliac disease, immunoglobulin (Ig)A-class autoantibodies against transglutaminase-2 are produced in the small intestinal mucosa, where they are deposited extracellularly. It remains unclear whether positive intestinal transglutaminase-2-targeted IgA deposits in subjects having normal small bowel mucosal morphology are signs of early-stage coeliac disease. We evaluated the gluten dependency of these deposits in overt and mild enteropathy coeliac disease.PATIENTS AND METHODS:All together 48 subjects suspected of coeliac disease but having normal small bowel mucosal villi were enrolled; 28 of them had latent coeliac disease. The remaining 20 having positive intestinal IgA deposits adopted a gluten-free diet before villous atrophy had developed. For comparison, 13 patients with overt coeliac disease and 42 noncoeliac controls were studied. Small bowel mucosal transglutaminase-2-specific autoantibodies were compared with villous morphology, intraepithelial lymphocyte densities, and serum coeliac autoantibodies.RESULTS:Intestinal IgA deposits were seen in all but 1 of the patients with latent coeliac disease, when the morphology was still intact; the intensity of these deposits increased as villous atrophy developed and decreased again on a gluten-free diet. In 20 patients with intestinal IgA deposits in normal villi, the intensity of the deposits decreased with the diet similarly to that seen in patients with overt coeliac disease. Mucosal IgA deposits were seen initially only in 5% of noncoeliac controls and in 8% after extended gluten consumption.CONCLUSIONS:The response of small bowel mucosal transglutaminase-2-specific IgA deposits for dietary intervention was similar in overt and mild enteropathy coeliac disease. Detection of such IgA deposits thus offers a good diagnostic tool to uncover early-stage coeliac disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition. - 47 : 4 (2008), p. 436-442. -
További szerzők:Collin, Pekka Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Salmi, T. T. Iltanen, Sari Haimila, Katri Partanen, Jukka Mäki, Markku Kaukinen, Katri
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

7.

001-es BibID:BIBFORM036331
Első szerző:Kovács Márta
Cím:Pancreatic autoantibodies and autoantibodies against goblet cells in pediatric patients with inflammatory bowel disease (IBD) / Kovacs Marta, Lakatos Peter Laszlo, Papp Maria, Jacobsen Silvia, Nemes Eva, Polgar Marianne, Solyom Eniko, Bodi Piroska, Horvath Agnes, Muller Katalin Eszter, Molnar Kriszta, Szabo Doloresz, Cseh Aron, Dezsofi Antal, Arato Andras, Veres Gabor
Dátum:2012
ISSN:0277-2116
Megjegyzések:Significance of pancreatic autoantibodies determined by using exocrine pancreas (PAB) and recombinant pancreas antigens (rPAB), as well as importance of autoantibodies against goblet cells (GAB) are not known in pediatric patients with inflammatory bowel disease (IBD). Our aim was to determine the complex analysis of PAB, rPAB, GAB, antibodies against Saccharomyces cerevisiae (ASCA), and perinuclear components of neutrophils (pANCA) in pediatric IBD patients. Moreover, association with NOD2/CARD15 and disease phenotype was determined. METHODS: 152 pediatric patients (median age 13.9 years) with IBD [103 patients with Crohn's disease (CD) and 49 patients with ulcerative colitis (UC)] and 104 controls were included. Serum autoantibodies were determined by indirect immunofluorescens assay. NOD2/CARD15 variants were tested by polymerase chain reaction/restriction fragment length polymorphism. RESULTS: The presence of PAB and rPAB was significantly higher in CD (34% and 35.9%) and in UC (20.4% and 24.5%) compared to pediatric control cohort (0% and 0%, p < 0.0001). In addition, GAB positivity was significantly increased in patients with UC in comparison to CD and controls, respectively (UC, 12.2%, CD, 1.9%, controls, 1.9%, p=0.02). Specificity of PAB and rPAB was 100%, however, sensitivity was low. The combination of PAB and/or ASCA/pANCA improved the sensitivity of serological markers in CD (87.4%) and in UC (79.6%); specificities were 89.3% and 93.2%, respectively. Pancreatic autoantibodies (PAB, rPAB) and GAB were not related to clinical presentation, medical therapy or need for surgery in CD or in UC. CONCLUSIONS: Pancreatic autoantibodies and GAB were specific for IBD but the sensitivity was limited as well as there was lack of correlation with clinical phenotype. Combinations of these antibodies have shown increased sensitivity, therefore, it may be recommended in the diagnostic procedure of IBD.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition 55 : 4 (2012), p. 429-435. -
További szerzők:Lakatos Péter (Semmelweis Egyetem) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Jacobsen, Silvia Nemes Éva (1957-) (csecsemő- és gyermekgyógyász, gasztroenterológus) Polgár Marianna Sólyom Enikő Bodi Piroska Horváth Ágnes (Veszprém) Müller Katalin Eszter Molnár Kriszta Szabó Dolóresz Cseh Áron Dezsőfi Antal Arató András Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

8.

001-es BibID:BIBFORM023716
Első szerző:Raivio, Tiina
Cím:Comparison of a novel whole blood transglutaminase-based ELISA with whole blood rapid antibody test and established conventional serological coeliac disease assays / Raivio T., Korponay-Szabó I. R., Paajanen T., Ashorn M., Iltanen S., Collin P., Laurila K., Nemes É., B. Kovács J., Carrard G., Saramaki M., Maki M., Kaukinen K.
Dátum:2008
Megjegyzések:Serum immunoglobulin A-class tissue transglutaminase (tTG-ab) and endomysial antibody (EMA) tests play a key role in the diagnostic evaluation of celiac disease. Recently, a novel whole blood rapid test based on self-tissue transglutaminase (tTG) was developed for celiac disease case finding. Based on the same principle, a whole blood self-tTG enzyme-linked immunosorbent assay (ELISA), especially applicable to large-scale screening of celiac disease, has been produced. We assessed the value of this new test in celiac disease antibody detection. PATIENTS AND METHODS: The new test uses endogenous tTG found in red blood cells of whole blood in IgA-class tTG-ab measurement by detecting tTG-tTG-ab complexes formed after hemolysis of the whole blood sample. Stored whole blood samples from 150 untreated celiac disease patients and 107 control individuals without celiac disease were evaluated, and the test results were compared with those of the whole blood rapid test, 2 conventional serum-based tTG-ab ELISA tests, and 2 EMA tests. RESULTS: A total of 15 whole blood samples were found to be clotted or dried after storage and were excluded from further evaluation. The whole blood ELISA test had a specificity (98%) comparable to that of the conventional serological tests, the sensitivity (91%) being slightly lower. The test was concordant with the whole blood rapid test in 92% of cases, with 2 serological ELISA tests in 91% and 94% of cases and with EMA tests in 94% and 93% of cases. CONCLUSIONS: Whole blood self-tTG-based testing is accurate in celiac antibody detection, also when an ELISA method is applied. The testing requires no serum separation or external tTG.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Pediatric Gastroenterology and Nutrition. - 47 : 5 (2008), p. 562-567. -
További szerzők:Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Paajanen, Tuula Ashorn, Merja Iltanen, Sari Collin, Pekka Laurila, Kaija Nemes Éva (1957-) (csecsemő- és gyermekgyógyász, gasztroenterológus) B. Kovács Judit Carrard, Géraldine Saramäki, Mika Mäki, Markku Kaukinen, Katri
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

9.

001-es BibID:BIBFORM044265
Első szerző:Ribes-Koninckx, Carmen
Cím:Coeliac Disease Diagnosis : ESPGHAN 1990 Criteria or Need For a Change? Results of a Questionnaire / C. Ribes-Koninckx, M. L. Mearin, I. R. Korponay-Szabó, R. Shamir, S. Husby, A. Ventura, D. Branski, C. Catassi, S. Koletzko, M. Mäki, R. Troncone, K. P. Zimmer, the ESPGHAN Working Group on Coeliac Disease Diagnosis
Dátum:2012
ISSN:0277-2116
Megjegyzések:INTRODUCTION:: A revision of criteria for diagnosing celiac disease (CD) is currently being conducted by ESPGHAN. In parallel, we have performed a survey aimed to evaluate current practices for CD among pediatric gastroenterologists (PG) and to learn their views on the need for modification of current criteria for CD diagnosis. METHODS:: Questionnaires were distributed to experienced PG (ESPGHAN members) via internet. RESULTS:: Overall, 95 valid questionnaires were available for analysis, pertaining to 28 different countries, with the majority of responders treating CD patients for more than 15 years. Only about 12% of the responders comply with current criteria, noncompliance being related mainly to the challenge policy.About 90 % request a revision and modification of the current criteria. 44% want to omit the SBB in symptomatic children with positive anti-tissue Transglutaminase (tTG) IgA or endomysial (EMA) IgA antibodies, specially if they are DQ2/DQ8 positive. For silent cases detected by screening with convincingly positive tTG IgA or EMA IgA, about 30% consider that no small bowel biopsy (SBB) should be required in selected cases. Adding HLA typing in the diagnostic work up was asked for by 42% of the responders. As for gluten challenge a new policy is advocated restricting its obligation to cases whenever the diagnosis is doubtful or unclear. CONCLUSIONS:: Based on these opinions, revision of the ESPGHAN criteria for diagnosing CD is urgently needed.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
celiac disease
Megjelenés:Journal of Pediatric Gastroenterology and Nutrition. - 54 : 1 (2012), p. 15-19. -
További szerzők:Mearin, Maria Luisa Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Shamir, R. Husby, Steffen Ventura, Alessandro Branski, D. Catassi, Carlo Koletzko, Sibylle Mäki, Markku Troncone, Riccardo Zimmer, Klaus-Peter the ESPGHAN Working Group on Coeliac Disease Diagnosis
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

10.

001-es BibID:BIBFORM096518
Első szerző:Riznik, Petra
Cím:Clinical Presentation in Children With Coeliac Disease in Central Europe / Riznik Petra, De Leo Luigina, Dolinsek Jasmina, Gyimesi Judit, Klemenak Martina, Koletzko Berthold, Koletzko Sibylle, Korponay-Szabó Ilma Rita, Krencnik Tomaz, Not Tarcisio, Palcevski Goran, Sblattero Daniele, Werkstetter Katharina Julia, Dolinsek Jernej
Dátum:2021
ISSN:0277-2116
Megjegyzések:Objectives: During the past decades, there has been a shift in the clinical presentation of coeliac disease (CD) to nonclassical, oligosymptomatic, and asymptomatic forms. We assessed clinical presentation of CD in children and adolescents in Central Europe. Methods: Paediatric gastroenterologists in 5 countries retrospectively reported data of their patients diagnosed with CD. Clinical presentation was analyzed and the differences among very young (<3 years) and older children and adolescents were studied. Results: Data from 653 children and adolescents (median age 7 years 2 months; 63.9% girls) from Croatia, Germany, Hungary, Italy, and Slovenia were available for the analysis. One fifth (N = 134) of all children were asymptomatic. In symptomatic children, the most common leading symptom was abdominal pain (33.3%), followed by growth retardation (13.7%) and diarrhoea (13.3%). The majority of symptomatic children (47.6%; N = 247) were polysymptomatic. Abdominal pain was the most common symptom in polysymptomatic (66.4%) as well as in monosymptomatic children (29.7%). Comparing clinical presentation of CD in very young children (younger than 3 years) with older children (3 years or older), we found that symptoms and signs of malabsorption were significantly more common in younger (P < 0.001), whereas abdominal pain and asymptomatic presentation were more common in older children and adolescents (both P < 0.001). Conclusion: In children with CD, abdominal pain has become the most common symptom. However, in younger children, symptoms of malabsorption are still seen frequently. This raises a question about the underlying mechanism of observed change in clinical presentation in favour of nonclassical presentation and asymptomatic disease at certain age.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
coeliac disease
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition. - 72 : 4 (2021), p. 546-551. -
További szerzők:De Leo, Luigina Dolinsek, Jasmina Gyimesi Judit Klemenak, Martina Koletzko, Berthold Koletzko, Sibylle Korponay-Szabó Ilma (1959-) (gyermekgyógyász) Krencnik, Tomaz Not, Tarcisio Palcevski, Goran Sblattero, Daniele Werkstetter, Katharina (gyermekgyógyász, gasztroenterológus) Dolinśek, Jernej
Pályázati támogatás:Interreg Central Europe CE111
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1 
Corvina könyvtári katalógus v8.2.27 © 2023 Monguz kft. Minden jog fenntartva.