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001-es BibID:	BIBFORM040457
035-os BibID:	PMID:8221666
Első szerző:	Cermak, Jaroslav
Cím:	Tumor cell heme uptake induces ferritin synthesis resulting in altered oxidant sensitivity : possible role in chemotherapy efficacy / Jaroslav Cermak, József Balla, Harry S. Jacob, György Balla, Helen Enright, Karl Nath, Gregory M. Vercellotti
Dátum:	1993
ISSN:	0008-5472
Megjegyzések:	Neovascularization and hemorrhage are common features of malignant tumors. We wondered whether hemoglobin derived from extravasated RBC deposits heme-derived iron into the tumor, which could modulate the sensitivity of cancer cells to oxidant-mediated injury. A brief exposure (1 h) of 51Cr-radiolabeled breast cancer cells (BT-20) but not colon cancer cells (Caco-2) to hemin (10 microM) or FeSO4 (10 microM) significantly enhances cytotoxicity mediated by 0.5 mM hydrogen peroxide (H2O2). Associated with Caco-2 resistance, these cells were found to be enriched in the endogenous iron chelator, ferritin. If cellular ferritin is even further increased through 1 h incubation (24 h prior to H2O2 exposure) of both cell types with hemin, FeSO4, or exogenous spleen apoferritin itself (24 h), marked resistance to H2O2-mediated cytotoxicity is manifest. Under several conditions, the sensitivity of tumor cells to oxidant-mediated lysis is inversely proportional to their ferritin content. Pretreatment of BT-20 and Caco-2 cells with hemin or FeSO4 rapidly increases H-ferritin mRNA but only slightly increases L-ferritin mRNA; nevertheless, large increases in overall ferritin content of iron-exposed cells result. Data analogous to those with H2O2-mediated cytotoxicity were obtained in studies of bleomycin-engendered DNA strand breakage and cell damage, i.e., brief treatment of BT-20 cells with both hemin or FeSO4 significantly increases their sensitivity to bleomycin (100 micrograms/ml), whereas treatment followed by 24 h incubation with media alone significantly protects against bleomycin toxicity. We speculate that acute exposure of tumors to iron (e.g., derived from heme-proteins in hemorrhagic cancerous lesions) may increase sensitivity of some cancer cells, particularly those relatively low in endogenous ferritin, to oxidant-mediated lysis. In contrast, repeated, more chronic, exposure effector cells or chemotherapeutic agents, an effect derived from their increased synthesis and accumulation of the intracellular iron scavenger, ferritin.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	Cancer Research 53 : 21 (1993), p. 5308-5313. -
További szerzők:	Balla József (1959-) (belgyógyász, nephrológus) Jacob, Harry S. Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Enright, Helen Nath, Karl Vercellotti, Gregory M.
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001-es BibID:	BIBFORM083522
Első szerző:	Simó-Riudalbas, Laia
Cím:	KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer / Laia Simo-Riudalbas, Montserrat Perez-Salvia, Fernando Setien, Alberto Villanueva, Catia Moutinho, Anna Martínez-Cardus, Sebastian Moran, Maria Berdasco, Antonio Gomez, Enrique Vidal, Marta Soler, Holger Heyn, Alejandro Vaquero, Carolina de la Torre, Silvia Barcelo-Batllori, August Vidal, Luca Roz, Ugo Pastorino, Katalin Szakszon, Guntram Borck, Conceição S. Moura, Fátima Carneiro, Ilse Zondervan, Suvi Savola, Reika Iwakawa, Takashi Kohno, Jun Yokota, Manel Esteller
Dátum:	2015
ISSN:	0008-5472 1538-7445
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Cancer Research. - 75 : 18 (2015), p. 3936-3945. -
További szerzők:	Pérez-Salvia, Montserrat Setien, Fernando Villanueva, Alberto Moutinho, Catia Martínez-Cardús, Anna Moran, Sebastian Berdasco, Maria Gomez, Antonio Vidal, Enrique Soler, Marta Heyn, Holger Vaquero, Alejandro Torre, Carolina de la Barceló-Batllori, Silvia Vidal, August Roz, Luca Pastorino, Ugo Szakszon Katalin (1977-) (csecsemő- és gyermekgyógyász, klinikai genetikus) Borck, Guntram Moura, Conceição S. Carneiro, Fátima Zondervan, Ilse Savola, Suvi Iwakawa, Reika Kohno, Takashi Yokota, Jun Esteller, Manel
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