CCL

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1.

001-es BibID:BIBFORM006107
Első szerző:Boldogh István
Cím:Colostrinin decreases hypersensitivity and allergic responses to common allergens / Istvan Boldogh, Leopoldo Aguilera-Aguirre, Attila Bacsi, Barun K. Choudhury, Alfredo Saavedra-Molina, Marian Kruzel
Dátum:2008
Megjegyzések:Colostrinin (TM) (CLN), isolated from mothers' pre-milk fluid (colostrum), is a uniform mixture of low-molecular-weight, proline-rich polypeptides. CLN induces neurite outgrowth of pheochromocytoma cells, extends the lifespan of diploid fibroblast cells, inhibits beta-amyloid-induced apoptosis and improves cognitive functions when administered to Alzheimer's disease patients. Objective: The aim of this study was to investigate potential allergic responses to CLN and its impact on allergic sensitization and inflammation caused by common allergens. Methods: We used a well-characterized mouse model of allergic airway inflammation. Changes in IgE/IgG1 and mucin levels, airway eosinophilia and hyperreactivity to methacholine were determined by ELISA, differential cell counting and whole-body plethysmography, respectively. Results: CLN did not increase IgE/IgG1 levels or induce cutaneous hypersensitivity reaction, airway inflammation and mucin production. Importantly, CLN significantly (p < 0.001) decreased IgE/IgG1 production, airway eosinophilia, mucin production and hypersensitivity induced by allergenic extracts from ragweed pollen grains and house dust mites. Conclusion: CLN itself is non-allergenic; however, it is effective in preventing allergic responses to known indoor and outdoor allergens. These data support the safe application of CLN and its potential use in the prevention of allergic inflammation in humans.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
colostrinin
immunoglobulin E
allergic inflammation
Megjelenés:International Archives of Allergy and Immunology. - 146 : 4 (2008), p. 298-306. -
További szerzők:Aguilera-Aguirre, Leopoldo Bácsi Attila (1967-) (immunológus) Choudhury, Barun K. Saavedra-Molina, Alfredo Kruzel, Marian L.
Internet cím:DOI
elektronikus változat
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2.

001-es BibID:BIBFORM065601
Első szerző:Pivarcsi Andor
Cím:Expression and function of Toll-like receptors 2 and 4 in human keratinocytes / Andor Pivarcsi, Laszlo Bodai, Bence Réthi, Anna Kenderessy-Szabó, Andrea Koreck, Márta Széll, Zsuzsanna Beer, Zsuzsanna Bata-Csörgő, Mária Magócsi, Éva Rajnavölgyi, Attila Dobozy, Lajos Kemény
Dátum:2003
ISSN:1460-2377
Megjegyzések:Keratinocytes have the ability to kill pathogenic fungi and bacteria by producing antimicrobial substances. Recent studies suggest that microbial components use signaling molecules of the human Toll-like receptor (TLR) family to transduce signals in various cells. Here we provide evidence that keratinocytes express both TLR2 and TLR4 at the mRNA and protein levels, and show that TLR2 and TLR4 are present in the normal human epidermis in vivo and that their expression is regulated by microbial components. The expression of myeloid differentiation protein gene (MyD88), which is involved in the signaling pathway of many TLR, was also demonstrated in keratinocytes. LPS + IFN-gamma increased the expression of TLR2 and TLR4 50- and 5-fold respectively. Treatment of keratinocytes with Candida albicans, mannan, Mycobacterium tuberculosis or LPS with IFN-gamma resulted in the activation and nuclear translocation of NF-kappaB. Inhibition of NF-kappaB blocked the Candida-killing activity of keratinocytes, suggesting that the antimicrobial effect of keratinocytes requires NF-kappaB activation. LPS + IFN-gamma, C. albicans (4 Candida/KC), peptidoglycan (1 micro g/ml) or M. tuberculosis extract significantly increased IL-8 gene expression after 3 h of treatment (P < 0.05). The increases over the 0-h level were 15-, 8-, 10.8- and 7-fold, respectively. The microbial compound-induced increase in IL-8 gene expression could be inhibited by anti-TLR2 and anti-TLR4 neutralizing antibodies, suggesting that TLRs are involved in the pathogen-induced expression of this pro-inflammatory cytokine. Our findings stress the importance of the role of keratinocytes as a component of innate immunity.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
epidermis
host defense
IL-8
innate immunity
NF-kB
Megjelenés:International Immunology 15 : 6 (2003), p. 721-730. -
További szerzők:Bodai László Réthi Bence (1973-) (biológus, immunológus) Kenderessy Szabó Anna Koreck Andrea Széll Márta Beer Zsuzsanna Bata-Csörgő Zsuzsanna Magócsi Mária Rajnavölgyi Éva (1950-) (immunológus) Dobozy Attila Kemény Lajos
Pályázati támogatás:T 032496
OTKA
T 030749
OTKA
T 032498
OTKA
T 032494
OTKA
FKFP 1271
Egyéb
FKFP 0222
Egyéb
AKP grant 2000-151 3,2
Egyéb
EU5 QLK4-CT2001-00366
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM030141
Első szerző:Simon Tünde (biokémikus, molekuláris biológus)
Cím:Asthma endophenotypes and polymorphisms in the histamine receptor HRH4 gene / Tünde Simon, Ágnes F. Semsei, Ildikó Ungvári, Éva Hadadi, Viktor Virág, Adrienne Nagy, Mónika S. Vangor, Valéria László, Csaba Szalai, András Falus
Dátum:2012
ISSN:1018-2438
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
SNP
histamine H4 receptor
Megjelenés:International Archives Of Allergy And Immunology. - 159 : 2 (2012), p. 109-120. -
További szerzők:F. Semsei Ágnes Ungvári Ildikó Hadadi Éva Virág Viktor Nagy Adrienne S. Vángor Mónika László Valéria Szalai Csaba Falus András
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM028889
Első szerző:Simon Tünde (biokémikus, molekuláris biológus)
Cím:Histamine modulates multiple functional activities of monocyte-derived dendritic cell subsets via histamine receptor 2 / Simon T., Gogolák P., Kis-Tóth K., Jelinek I., László V., Rajnavölgyi E.
Dátum:2012
ISSN:0953-8178
Megjegyzések:Expression of CD1a proteins in human monocyte-derived dendritic cells (DCs) specifies functionally distinct subsets with different inflammatory properties. Histamine is recognized as an inflammatory mediator released by various cell types including DCs. The diverse biological effects of histamine are mediated by G-protein-coupled histamine receptors (HRs), which are able to modulate the functional activities of DC subsets. The goal of the present study was to compare the expression and activity of HRs in the CD1a- and CD1a+ monocyte-derived DC subsets and to test the effects of histamine on the differentiation, activation and functional activities of these subsets. We show that H2R is present at high levels in both DC subsets, whereas H1R and H4R are expressed in a subset-specific manner. Histamine shifts DC differentiation to the development of CD1a- DCs and modulates DC activation through its inhibitory effect on CD1a+ DC differentiation. Histamine-induced reduction of CD1a+ DCs is associated with increased secretion of IL-6 and IL-10, up-regulation of a typical combination of chemokines, expression C5aR1 by the CD1a- DC subset and enhanced migration of both activated DC subsets supported by the production of MMP-9 and MMP-12 enzymes. All these effects were shown to be mediated in a H2R-specific manner as revealed by the specific antagonist of the receptor. As H2R is expressed at high levels in both DC subsets, we propose that it may dominate the regulation of multiple DC functions. In contrast, H1R and H4R with opposing subset-related expression may have a regulatory or fine-tuning role in histamine-induced functional activities.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
hisztamin
dendritikus sejt
Megjelenés:International Immunology. - 24 : 2 (2012), p. 107-116. -
További szerzők:Gogolák Péter (1968-) (biológus, immunológus) Kis-Tóth Katalin (1975-) (immunológus) Jelinek Ivett László Valéria Rajnavölgyi Éva (1950-) (immunológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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5.

001-es BibID:BIBFORM048346
Első szerző:Wei, S. M.
Cím:Epitope specificity of monoclonal and polyclonal antibodies to human elastin / S.M. Wei, E. Katona, J. Fachet, T. Fülöp Jr., L. Robert, M.P. Jacob
Dátum:1998
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
elastin
Megjelenés:International Archives of Allergy and Immunology. - 115 (1998), p. 33-41. -
További szerzők:Katona Éva (1961-) (klinikai biokémikus) Fachet József (1935-2016) (immunológus, kórélettanász) Fülöp Tamás Jr Robert, Ladislas Jacob, Marie-Paule
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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