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001-es BibID:	BIBFORM040507
035-os BibID:	PMID:4044098
Első szerző:	Sipka Sándor (laboratóriumi szakorvos)
Cím:	Effect of lentinan on the chemiluminescence produced by human neutrophils and the murine macrophage cell line C4M phi / Sándor Sipka, György Ábel, József Csongor, Goro Chihara, József Fachet
Dátum:	1985
Megjegyzések:	Lentinan, an immunopotentiating polysaccharide, stimulates the production of chemiluminescence (CL) by human neutrophils and the murine macrophage cell line C4M phi. The CL enhancing effect of lentinan opsonized in human serum is greater than that of lentinan itself. Lentinan's stimulation of neutrophil CL was increased by 1/2 when opsonized in human serum inactivated at 56 degrees C to remove complement, while the CL was increased two fold by lentinan opsonized in whole serum. This indicates that C3b and immunoglobulin contribute separate signals in the activation process mediated by opsonized lentinan. The distinct roles of the C3b and Fc receptors was further illuminated by the finding that an Fc receptor-negative cell line was unresponsive to lentinan opsonized in heat inactivated serum (56 degrees C), whereas it exhibited a five fold increase in CL in response to lentinan opsonized in serum containing complement. Lentinan in an opsonized form can stimulate the production of CL via C3b and Fc receptors. This mechanism may be considered as one mode of action of lentinan and other similar immunopotentiating and antitumour glucan-type polysaccharides.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	International Journal of Immunopharmacology. - 7 : 5 (1985), p. 747-751. -
További szerzők:	Ábel György Csongor József Chihara, Goro Fachet József (1935-2016) (immunológus, kórélettanász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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