Találati lista | Tudóstér

001-es BibID:	BIBFORM006757
Első szerző:	Fodor Mariann (szemész)
Cím:	Enhanced release of IL-6 and IL-8 into tears in various anterior segment eye diseases / Fodor, M., Facsko, A., Rajnavolgyi, E., Harsfalvi, J., Bessenyei, E., Kardos, L., Berta, A.
Dátum:	2006
Megjegyzések:	To determine the levels of interleukin 6 (IL-6) and interleukin 8 (IL-8/CXCL-8) in tears collected from the eyes of normal individuals and of patients with different irritative eye diseases, in order to acquire information on the immunological changes occurring during the early postoperative period following various forms of eye surgery, including penetrating keratoplasty (PKP). METHODS: IL-6 and IL-8 levels were measured with the aid of human ultrasensitive ELISA kits in the non-stimulated tears of patients in the early postoperative period following PKP or cataract operation, and of patients with acute bacterial conjunctivitis or with a corneal foreign body. The IL-6 and IL-8 concentrations, the total amounts released in a given time and the rates of their release were calculated. RESULTS: A significant increase in IL-6 release was observed in all patient groups compared with the normal controls (p < or = 0.003). The IL-8 release levels were significantly higher in the tears of all patient groups (p < or = 0.03), except for the cataract operation group, where the IL-8 release was not significantly higher (p = 0.053) than in the control samples. No significant differences in IL-6 or IL-8 release were observed when the various patient groups were compared with each other. CONCLUSION: The release of IL-6 and IL-8 into the tears is enhanced in various anterior segment eye diseases, and this may be used as an indicator of various inflammatory reactions in the early postoperative period.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Aged, 80 and over Anterior Eye Segment Biological Markers Cataract Cataract Extraction Conjunctivitis, Bacterial Corneal Diseases Enzyme-Linked Immunosorbent Assay Follow-Up Studies Humans Interleukin-6 Interleukin-8 Middle Aged Prognosis Severity of Illness Index Tears
Megjelenés:	Ophthalmic Research. - 38 : 4 (2006), p. 182-188. -
További szerzők:	Facskó Andrea (1953-) (szemész) Rajnavölgyi Éva (1950-) (immunológus) Hársfalvi Jolán (1949-) (klinikai biokémikus) Bessenyei Emilia Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Berta András (1955-) (szemész, gyermekszemész)
Internet cím:	elektronikus változat DOI
Borító:
Saját polcon:

001-es BibID:	BIBFORM048804
Első szerző:	Kolozsvári Bence Lajos (szemész)
Cím:	Association between mediators in the tear fluid and the severity of keratoconus / Bence Lajos Kolozsvári, Goran Petrovski, Péter Gogolák, Éva Rajnavölgyi, Flóra Tóth, András Berta, Mariann Fodor
Dátum:	2013
ISSN:	0030-3747
Megjegyzések:	Purpose: To study the association between different types of mediators in the tear fluid and topographic indices characterizing the severity of keratoconus (KC). Methods: In this study, nonstimulated tear fluid samples were collected from 14 eyes of 11 patients with KC. The following indices were measured by corneal topography: maximum K value, average K value, Klyce/Maeda keratoconus index (KCI), Smolek/Klyce keratoconus severity index, opposite sector index, center/surround index, keratoconus prediction index and standard deviation of corneal power. The concentrations of interleukin (IL)-6, IL-13, CXCL8 (IL-8), chemokine (C-C motif) ligand 5 (CCL5, regulated and normal T cell expressed and secreted), matrix metalloproteinase-9 (MMP-9), MMP-13, tissue inhibitor of metalloproteinase-1, nerve growth factor (NGF) and epidermal growth factor were measured by cytometric bead array technology. Release of mediators was calculated from their concentrations and the volume of tears collected over 2 min. Results: Significant positive associations were found between CCL5, MMP-13 and NGF and several topographic indices. Significant negative correlations were found between IL-6 and KCI. Age-dependent associations were observed between IL-13, CXCL8, CCL5 and MMP-13 and the topographic data. Conclusion: Several correlations were observed between the mediators and the topographic indices, suggesting possible roles in the pathophysiology of KC. Our data indicate that some mediators have different effects on the severity of disease in an age-dependent manner.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Ophthalmic Research. - 51 : 1 (2013), p. 46-51. -
További szerzők:	Petrovski, Goran (1975-) (orvos) Gogolák Péter (1968-) (biológus, immunológus) Rajnavölgyi Éva (1950-) (immunológus) Tóth Flóra Berta András (1955-) (szemész, gyermekszemész) Fodor Mariann (1975-) (szemész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: