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1.

001-es BibID:BIBFORM005623
Első szerző:Bagi Zsolt (orvos)
Cím:High intraluminal pressure via H2O2 upregulates arteriolar constrictions to angiotensin II by increasing the functional availability of AT1 receptors / Bagi, Z., Erdei, N., Koller, A.
Dátum:2008
ISSN:0363-6135 (Print)
Megjegyzések:Previously, we found that high intraluminal pressure leads to production of reactive oxygen species (ROS) and also upregulates several components of the renin-angiotensin system in the wall of small arteries. We hypothesized that acute exposure of arterioles to high intraluminal pressure in vitro via increasing ROS production enhances the functional availability of type 1 angiotensin II (Ang II) receptors (AT1 receptors), resulting in sustained constrictions. In arterioles ( approximately 180 mum) isolated from rat skeletal muscle, Ang II elicited dose-dependent constrictions, which decreased significantly by the second application [maximum (max.): from 59% +/- 4% to 26% +/- 5% at 10(-8) M; P < 0.05] in the presence of 80 mmHg of intraluminal pressure. In contrast, if the arterioles were exposed to high intraluminal pressure (160 mmHg for 30 min), Ang II-induced constrictions remained substantial on the second application (max.: 51% +/- 3% at 10(-8) M). In the presence of Tiron and polyethylene glycol (PEG)-catalase, known to reduce the level of superoxide anion and hydrogen peroxide (H(2)O(2)), second applications of Ang II evoked similarly reduced constrictions, even after high-pressure exposure (29% +/- 4% at 10(-8) M). Furthermore, when arterioles were exposed to H(2)O(2) (for 30 min, 10(-7) M, at normal 80 mmHg pressure), Ang II-induced constrictions remained substantial on second applications (59% +/- 5% at 10(-8) M). These findings suggest that high pressure, likely via inducing H(2)O(2) production, increases the functional availability of AT1 receptors and thus enhances Ang II-induced arteriolar constrictions. We propose that in hypertension-regardless of etiology-high intraluminal pressure, via oxidative stress, enhances the functional availability of AT1 receptors augmenting Ang II-induced constrictions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt/pharmacology
Angiotensin II
Animals
Antioxidants
Arterioles
Blood Pressure
Catalase
Hydrogen Peroxide
Hypertension
Male
Muscle
Oxidative Stress
Polyethylene Glycols
Rats
Rats, Wistar
Receptor
Up-Regulation
Vasoconstriction/drug effects
Megjelenés:American Journal of Physiology. Heart and Circulatory Physiology. - 295 : 2 (2008), p. H835-H841. -
További szerzők:Erdei Nóra (1979-) (orvos) Koller Ákos
Internet cím:elektronikus változat
elektronikus változat
DOI
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2.

001-es BibID:BIBFORM020103
Első szerző:Erdei Nóra (orvos)
Cím:High-fat diet-induced reduction in nitric oxide-dependent arteriolar dilation in rats: role of xanthine oxidase-derived superoxide anion / Nóra Erdei, Attila Tóth, Enikő T. Pásztor, Zoltán Papp, István Édes, Akos Koller, Zsolt Bagi
Dátum:2006
ISSN:0363-6135
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:American Journal Of Physiology-Heart And Circulatory Physiology. - 291 : 5 (2006), p. H2107-H2115. -
További szerzők:Tóth Attila (1971-) (biológus) Pásztorné Tóth Enikő (1966-) (laboratóriumi analitikus) Papp Zoltán (1965-) (kardiológus, élettanász) Édes István (1952-) (kardiológus) Koller Ákos Bagi Zsolt (1974-) (orvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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3.

001-es BibID:BIBFORM002023
Első szerző:Erdei Nóra (orvos)
Cím:H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in Type 2 diabetic mice / Erdei N., Bagi Z., Edes I., Kaley G., Koller A.
Dátum:2007
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:American Journal of Physiology. Heart and Circulatory Physiology. - 292 : 1 (2007), p. H649-H656. -
További szerzők:Édes István (1952-) (kardiológus) Kaley Gábor Koller Ákos Bagi Zsolt (1974-) (orvos)
Internet cím:elektronikus változat
DOI
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4.

001-es BibID:BIBFORM005634
Első szerző:Jebelovszki Éva
Cím:High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles : role of soluble guanylate cyclase activation / Jebelovszki, E., Kiraly, C., Erdei, N., Feher, A., Pasztor, T. E., Rutkai, I., Forster, T., Edes, I., Koller, A., Bagi, Z.
Dátum:2008
ISSN:0363-6135 (Print)
Megjegyzések:The impact of obesity on nitric oxide (NO)-mediated coronary microvascular responses is poorly understood. Thus NO-mediated vasomotor responses were investigated in pressurized coronary arterioles ( approximately 100 microm) isolated from lean (on normal diet) and obese (fed with 60% of saturated fat) rats. We found that dilations to acetylcholine (ACh) were not significantly different in obese and lean rats (lean, 83 +/- 4%; and obese, 85 +/- 3% at 1 microM), yet the inhibition of NO synthesis with N(omega)-nitro-l-arginine methyl ester reduced ACh-induced dilations only in vessels of lean controls. The presence of the soluble guanylate cyclase (sGC) inhibitor oxadiazolo-quinoxaline (ODQ) elicited a similar reduction in ACh-induced dilations in the two groups of vessels (lean, 60 +/- 11%; and obese, 57 +/- 3%). Dilations to NO donors, sodium nitroprusside (SNP), and diethylenetriamine (DETA)-NONOate were enhanced in coronary arterioles of obese compared with lean control rats (lean, 63 +/- 6% and 51 +/- 5%; and obese, 78 +/- 5% and 70 +/- 5%, respectively, at 1 microM), whereas dilations to 8-bromo-cGMP were not different in the two groups. In the presence of ODQ, both SNP and DETA-NONOate-induced dilations were reduced to a similar level in lean and obese rats. Moreover, SNP-stimulated cGMP immunoreactivity in coronary arterioles and also cGMP levels in carotid arteries were enhanced in obese rats, whereas the protein expression of endothelial NOS and the sGC beta1-subunit were not different in the two groups. Collectively, these findings suggest that in coronary arterioles of obese rats, the increased activity of sGC leads to an enhanced sensitivity to NO, which may contribute to the maintenance of NO-mediated dilations and coronary perfusion in obesity.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Acetylcholine
Adaptation, Physiological
Animals
Arterioles
Blotting, Western
Coronary Vessels
Cyclic GMP
Dietary Fats
Disease Models, Animal
Dose-Response Relationship, Drug
Enzyme Activation
Enzyme Inhibitors
Enzyme-Linked Immunosorbent Assay
Guanylate Cyclase
Immunohistochemistry
Male
NG-Nitroarginine Methyl Ester
Nitric Oxide
Nitric Oxide Donors
Nitric Oxide Synthase Type II
Nitroprusside
Nitroso Compounds
Obesity
Rats
Rats, Wistar
Receptors, Cytoplasmic and Nuclear
Vasodilation
Vasodilator Agents
Megjelenés:American Journal of Physiology. Heart and Circulatory Physiology. - 294 : 6 (2008), p. H2558-H2564. -
További szerzők:Király Csaba Erdei Nóra (1979-) (orvos) Fehér Attila (1982-) (orvos) Pásztorné Tóth Enikő (1966-) (laboratóriumi analitikus) Rutkai Ibolya (1985-) (molekuláris biológus) Forster Tamás Édes István (1952-) (kardiológus) Koller Ákos Bagi Zsolt (1974-) (orvos)
Internet cím:elektronikus változat
elektronikus változat
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5.

001-es BibID:BIBFORM003761
Első szerző:Nyolczas Noémi
Cím:Design and rationale for the Myocardial Stem Cell Administration After Acute Myocardial Infarction (MYSTAR) Study : a multicenter, prospective, randomized, single-blind trial comparing early and late intracoronary or combined (percutaneous intramyocardial and intracoronary) administration of nonselected autologous bone marrow cells to patients after acute myocardial infarction / Nyolczas, N., Gyongyosi, M., Beran, G., Dettke, M., Graf, S., Sochor, H., Christ, G., Edes, I., Balogh, L., Krause, K. T., Jaquet, K., Kuck, K. H., Benedek, I., Hintea, T., Kiss, R., Preda, I., Kotevski, V., Pejkov, H., Dudek, D., Heba, G., Sylven, C., Charwat, S., Jacob, R., Maurer, G., Lang, I., Glogar, D.
Dátum:2007
Megjegyzések:Previous data suggest that bone marrow-derived stem cells (BM-SCs) decrease the infarct size and beneficially affect the postinfarction remodeling. METHODS: The Myocardial Stem Cell Administration After Acute Myocardial Infarction Study is a multicenter, prospective, randomized, single-blind clinical trial designed to compare the early and late intracoronary or combined (percutaneous intramyocardial and intracoronary) administration of BM-SCs to patients after acute myocardial infarction (AMI) with reopened infarct-related artery. The primary end points are the changes in resting myocardial perfusion defect size and left ventricular ejection fraction (gated single photon emission computed tomography [SPECT] scintigraphy) 3 months after BM-SCs therapy. The secondary end points relate to evaluation of (1) the safety and feasibility of the application modes, (2) the changes in left ventricular wall motion score index (transthoracic echocardiography), (3) myocardial voltage and segmental wall motion (NOGA mapping), (4) left ventricular end-diastolic and end-systolic volumes (contrast ventriculography), and (5) the clinical symptoms (Canadian Cardiovascular Society [CCS] anina score and New York Heart Association [NYHA] functional class) at follow-up. Three hundred sixty patients are randomly assigned into 1 of 4 groups: group A, early treatment (21-42 days after AMI) with intracoronary injection; group B, early treatment with combined application; group C, late treatment (3 months after AMI) with intracoronary delivery; and group D, late treatment with combined administration of BM-SCs. Besides the BM-SCs therapy, the standardized treatment of AMI is applied in all patients. CONCLUSIONS: The Myocardial Stem Cell Administration After Acute Myocardial Infarction Trial is the first randomized trial to investigate the effects of the combined (intramyocardial and intracoronary) and the intracoronary mode of delivery of BM-SCs therapy in the early and late periods after AMI.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Bone Marrow Cells
Bone Marrow Transplantation
Coronary Vessels
Echocardiography
Humans
methods
Multicenter Studies as Topic
Myocardial Infarction
Myocardium
Perfusion
Prospective Studies
Research Design
Single-Blind Method
surgery
therapy
Time Factors
Megjelenés:American Heart Journal. - 153 : 2 (2007), p. 212-217. -
További szerzők:Gyöngyösi Mariann Beran, Gilbert Dettke, Markus Graf, Senta Sochor, Heinz Christ, Günther Édes István (1952-) (kardiológus) Balogh László (1976-) (kardiológus) Krause, Korff T. Jaquet, Kai Kuck, Karl Heinz Benedek Imre Hintea, Theodora Kiss Róbert Préda István Kotevski Vladimir Pejkov, Hristo Dudek, Darius Heba, Grzegorz Sylven, Christer Charwat, Silvia Jacob, Ronaldo Maurer, Gerald Lang, Irene Glogar, Dietmar
Internet cím:elektronikus változat
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6.

001-es BibID:BIBFORM020693
Első szerző:Tósaki Árpád (kísérletes farmakológus, gyógyszerész)
Cím:The role of peroxiredoxins in ischemia-reperfusion-induced cardiac damage / Árpád Tósaki, István Édes
Dátum:2006
ISSN:0363-6135
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:American Journal of Physiology-Heart And Circulatory Physiology. - 291 : 6 (2006), p. H2586-H2587. -
További szerzők:Édes István (1952-) (kardiológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM002143
Első szerző:Tóth Erika
Cím:Contribution of polyol pathway to arteriolar dysfunction in hyperglycemia : role of oxidative stress, reduced NO, and enhanced PGH(2)/TXA(2) mediation / Toth E., Racz A., Toth J., Kaminski P. M., Wolin M. S., Bagi Z., Koller A.
Dátum:2007
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:American Journal of Physiology. Heart and circulatory physiology. - 293 : 5 (2007), p. H3096-H3104. -
További szerzők:Rácz Anita Tóth János Kaminski, Pawel M. Wolin, Michael S. Koller Ákos Bagi Zsolt (1974-) (orvos)
Internet cím:elektronikus változat
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