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1.

001-es BibID:BIBFORM020592
Első szerző:Böhm, Michael
Cím:Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan, ramipril, or both : the ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (ONTARGET/TRANSCEND) Trials / Bohm, M., Baumhakel, M., Teo, K., Sleight, P., Probstfield, J., Gao, P., Mann, J. F., Diaz, R., Dagenais, G. R., Jennings, G. L. R., Liu, L., Jansky, P., Yusuf, S., the ONTARGET/TRANSCEND Erectile Dysfunction Substudy Investigators
Dátum:2010
ISSN:0009-7322
Megjegyzések:Although erectile dysfunction (ED) is associated with cardiovascular risk factors and atherosclerosis, it is not known whether the presence of ED is predictive of future events in individuals with cardiovascular disease. We evaluated whether ED is predictive of mortality and cardiovascular outcomes, and because inhibition of the renin-angiotensin system in high-risk patients reduces cardiovascular events, we also tested the effects on ED of randomized treatments with telmisartan, ramipril, and the combination of the 2 drugs (ONTARGET), as well as with telmisartan or placebo in patients who were intolerant of angiotensin-converting enzyme inhibitors (TRANSCEND). METHODS AND RESULTS: In a prespecified substudy, 1549 patients underwent double-blind randomization, with 400 participants assigned to receive ramipril, 395 telmisartan, and 381 the combination thereof (ONTARGET), as well as 171 participants assigned to receive telmisartan and 202 placebo (TRANSCEND). ED was evaluated at baseline, at 2-year follow-up, and at the penultimate visit before closeout. ED was predictive of all-cause death (hazard ratio [HR] 1.84, 95% confidence interval [CI] 1.21 to 2.81, P=0.005) and the composite primary outcome (HR 1.42, 95% CI 1.04 to 1.94, P=0.029), which consisted of cardiovascular death (HR 1.93, 95% CI 1.13 to 3.29, P=0.016), myocardial infarction (HR 2.02, 95% CI 1.13 to 3.58, P=0.017), hospitalization for heart failure (HR 1.2, 95% CI 0.64 to 2.26, P=0.563), and stroke (HR 1.1, 95% CI 0.64 to 1.9, P=0.742). The study medications did not influence the course or development of ED. CONCLUSIONS: ED is a potent predictor of all-cause death and the composite of cardiovascular death, myocardial infarction, stroke, and heart failure in men with cardiovascular disease. Trial treatment did not significantly improve or worsen ED. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT 00153101.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Circulation. - 121 : 12 (2010), p. 1439-1446. -
További szerzők:Baumhäkel, Magnus Teo, Koon Sleight, Peter Probstfield, Jeffrey Gao, Peggy Mann, Johannes F. Diaz, Rafael Dagenais, Gilles R. Jennings, Garry L. R. Liu, Lisheng Jansky, Petr Yusuf, Salim (1929-2008) (belgyógyász) Czuriga István (1948-2018) (kardiológus) the ONTARGET/TRANSCEND Erectile Dysfunction Substudy Investigators
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2.

001-es BibID:BIBFORM010417
Első szerző:Borbély Attila (kardiológus)
Cím:Transcriptional and posttranslational modifications of titin : implications for diastole / Borbely, A., van Heerebeek, L., Paulus, W. J.
Dátum:2009
ISSN:1524-4571 (Electronic)
Tárgyszavak:Orvostudományok Klinikai orvostudományok szerkesztőségi anyag
Alternative Splicing
Animals
Cyclic AMP-Dependent Protein Kinases
Cyclic GMP-Dependent Protein Kinases
Diabetes Complications
Diacetyl
derivatives
Diastole
Elasticity
Extracellular Matrix
Gelsolin
Heart Failure, Diastolic
Humans
Mice
Muscle Proteins
Myocytes, Cardiac
Phosphorylation
Protein Isoforms
Protein Kinases
Protein Processing, Post-Translational
Rats
Sarcomeres
Triiodothyronine
Ventricular Remodeling
Megjelenés:Circulation Research. - 104 : 1 (2009), p. 12-14. -
További szerzők:Heerebeek, Loek, van Paulus, Walter J.
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3.

001-es BibID:BIBFORM010415
Első szerző:Borbély Attila (kardiológus)
Cím:Hypophosphorylation of the Stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium / Borbely, A., Falcao-Pires, I., van Heerebeek, L., Hamdani, N., Edes, I., Gavina, C., Leite-Moreira, A. F., Bronzwaer, J. G. F., Papp, Z., van der Velden, J., Stienen, G. J. M., Paulus, W. J.
Dátum:2009
ISSN:1524-4571 (Electronic)
Megjegyzések:High diastolic stiffness of failing myocardium results from interstitial fibrosis and elevated resting tension (F(passive)) of cardiomyocytes. A shift in titin isoform expression from N2BA to N2B isoform, lower overall phosphorylation of titin, and a shift in titin phosphorylation from N2B to N2BA isoform can raise F(passive) of cardiomyocytes. In left ventricular biopsies of heart failure (HF) patients, aortic stenosis (AS) patients, and controls (CON), we therefore related F(passive) of isolated cardiomyocytes to expression of titin isoforms and to phosphorylation of titin and titin isoforms. Biopsies were procured by transvascular technique (44 HF, 3 CON), perioperatively (25 AS, 4 CON), or from explanted hearts (4 HF, 8 CON). None had coronary artery disease. Isolated, permeabilized cardiomyocytes were stretched to 2.2-microm sarcomere length to measure F(passive). Expression and phosphorylation of titin isoforms were analyzed using gel electrophoresis with ProQ Diamond and SYPRO Ruby stains and reported as ratio of titin (N2BA/N2B) or of phosphorylated titin (P-N2BA/P-N2B) isoforms. F(passive) was higher in HF (6.1+/-0.4 kN/m(2)) than in CON (2.3+/-0.3 kN/m(2); P<0.01) or in AS (2.2+/-0.2 kN/m(2); P<0.001). Titin isoform expression differed between HF (N2BA/N2B=0.73+/-0.06) and CON (N2BA/N2B=0.39+/-0.05; P<0.001) and was comparable in HF and AS (N2BA/N2B=0.59+/-0.06). Overall titin phosphorylation was also comparable in HF and AS, but relative phosphorylation of the stiff N2B titin isoform was significantly lower in HF (P-N2BA/P-N2B=0.77+/-0.05) than in AS (P-N2BA/P-N2B=0.54+/-0.05; P<0.01). Relative hypophosphorylation of the stiff N2B titin isoform is a novel mechanism responsible for raised F(passive) of human HF cardiomyocytes.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Aged
Biopsy
Elasticity
Female
Heart Failure
Humans
Male
Middle Aged
Muscle Proteins
Myocardium
Myocytes, Cardiac
Phosphorylation
Protein Isoforms
Protein Kinases
Sarcomeres
Megjelenés:Circulation Research. - 104 : 6 (2009), p. 780-786. -
További szerzők:Falcao-Pires, Ines Heerebeek, Loek, van Hamdani, Nazha Édes István (1952-) (kardiológus) Gavina, Cristina Leite-Moreira, Adelino F. Bronzwaer, Jean G. F. Papp Zoltán (1965-) (kardiológus, élettanász) Velden, Jolanda, van der Stienen, Ger J. M. Paulus, Walter J.
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4.

001-es BibID:BIBFORM023507
Első szerző:Falcao-Pires, Ines
Cím:Diabetes Mellitus Worsens Diastolic Left Ventricular Dysfunction in Aortic Stenosis Through Altered Myocardial Structure and Cardiomyocyte Stiffness / Falcao-Pires, I., Hamdani, N., Borbely, A., Gavina, C., Schalkwijk, C. G., van der Velden, J., van Heerebeek, L., Stienen, G. J. M., Niessen, H. W. M., Leite-Moreira, A. F., Paulus, W. J.
Dátum:2011
ISSN:0009-7322
Megjegyzések:Aortic stenosis (AS) and diabetes mellitus (DM) are frequent comorbidities in aging populations. In heart failure, DM worsens diastolic left ventricular (LV) dysfunction, thereby adversely affecting symptoms and prognosis. Effects of DM on diastolic LV function were therefore assessed in aortic stenosis, and underlying myocardial mechanisms were identified. Methods and Results-Patients referred for aortic valve replacement were subdivided into patients with AS and no DM (AS; n=46) and patients with AS and DM (AS-DM; n=16). Preoperative Doppler echocardiography and hemodynamics were implemented with perioperative LV biopsies. Histomorphometry and immunohistochemistry quantified myocardial collagen volume fraction and myocardial advanced glycation end product deposition. Isolated cardiomyocytes were stretched to 2.2-gamma m sarcomere length to measure resting tension (Fpassive). Expression and phosphorylation of titin isoforms were analyzed with gel electrophoresis with ProQ Diamond and SYPRO Ruby stains. Reduced LV end-diastolic distensibility in AS-DM was evident from higher LV end-diastolic pressure (21±1 mm Hg for AS versus 28±4 mm Hg for AS-DM; P=0.04) at comparable LV end-diastolic volume index and attributed to higher myocardial collagen volume fraction (AS, 12.9±1.1% versus AS-DM, 18.2±2.6%; P<0.001), more advanced glycation end product deposition in arterioles, venules, and capillaries (AS, 14.4±2.1 score per 1 mm2 versus AS-DM, 31.4±6.1 score per 1 mm2; P=0.03), and higher Fpassive (AS, 3.5±1.7 kN/m2 versus AS-DM, 5.1±0.7 kN/m2; P=0.04). Significant hypophosphorylation of the stiff N2B titin isoform in AS-DM explained the higher Fpassive and normalization of Fpassive after in vitro treatment with protein kinase A. Conclusions-Worse diastolic LV dysfunction in AS-DM predisposes to heart failure and results from more myocardial fibrosis, more intramyocardial vascular advanced glycation end product deposition, and higher cardiomyocyte Fpassive, which was related to hypophosphorylation of the N2B titin isoform.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
aortic valve stenosis
myocytes
cardiac
diabetes mellitus
diastole
fibrosis
titin
myofilamentary proteins
Megjelenés:Circulation. - 124 : 10 (2011), p. 1151-1159. -
További szerzők:Hamdani, Nazha Borbély Attila (1978-) (kardiológus) Gavina, Cristina Schalkwijk, Casper G. Velden, Jolanda, van der Heerebeek, Loek, van Stienen, Ger J. M. Niessen, Hans W. M. Leite-Moreira, Adelino F. Paulus, Walter J.
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5.

001-es BibID:BIBFORM030333
Első szerző:Heerebeek, Loek, van
Cím:Response to Letter Regarding Article, "Diastolic Stiffness of the Failing Diabetic Heart : Importance of Fibrosis, Advanced Glycation End Products, and Myocyte Resting Tension" / van Heerebeek L., Hamdani N., Handoko M. L., Falcao-Pires I., Musters R. J., Kupreishvili K., Ijsselmuiden A. J., Schalkwijk C. G., Bronzwaer J. G., Diamant M., Borbely A., van der Velden J., Stienen G. J. M., Laarman G. J., Niessen H. W., Paulus W. J.
Dátum:2008
ISSN:0009-7322
Tárgyszavak:Orvostudományok Elméleti orvostudományok levél
Megjelenés:Circulation. - 117 (2008), p. e484. -
További szerzők:Hamdani, Nazha Handoko, Martin Louis Falcao-Pires, Ines Musters, René J. Kupreishvili, Koba Ijsselmuiden, Alexander J. J. Schalkwijk, Casper G. Bronzwaer, Jean G. F. Diamant, Michaela Borbély Attila (1978-) (kardiológus) Velden, Jolanda, van der Stienen, Ger J. M. Laarman, Gerrit J. Niessen, Hans W. M. Paulus, Walter J.
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6.

001-es BibID:BIBFORM005642
Első szerző:Heerebeek, Loek, van
Cím:Diastolic stiffness of the failing diabetic heart : importance of fibrosis, advanced glycation end products, and myocyte resting tension / van Heerebeek, L., Hamdani, N., Handoko, M. L., Falcao-Pires, I., Musters, R. J., Kupreishvili, K., Ijsselmuiden, A. J. J., Schalkwijk, C. G., Bronzwaer, J. G. F., Diamant, M., Borbely, A., van der Velden, J., Stienen, G. J. M., Laarman, G. J., Niessen, H. W. M., Paulus, W. J.
Dátum:2008
ISSN:1524-4539 (Electronic)
Megjegyzések:Excessive diastolic left ventricular stiffness is an important contributor to heart failure in patients with diabetes mellitus. Diabetes is presumed to increase stiffness through myocardial deposition of collagen and advanced glycation end products (AGEs). Cardiomyocyte resting tension also elevates stiffness, especially in heart failure with normal left ventricular ejection fraction (LVEF). The contribution to diastolic stiffness of fibrosis, AGEs, and cardiomyocyte resting tension was assessed in diabetic heart failure patients with normal or reduced LVEF. METHODS AND RESULTS: Left ventricular endomyocardial biopsy samples were procured in 28 patients with normal LVEF and 36 patients with reduced LVEF, all without coronary artery disease. Sixteen patients with normal LVEF and 10 with reduced LVEF had diabetes mellitus. Biopsy samples were used for quantification of collagen and AGEs and for isolation of cardiomyocytes to measure resting tension. Diabetic heart failure patients had higher diastolic left ventricular stiffness irrespective of LVEF. Diabetes mellitus increased the myocardial collagen volume fraction only in patients with reduced LVEF (from 14.6+/-1.0% to 22.4+/-2.2%, P<0.001) and increased cardiomyocyte resting tension only in patients with normal LVEF (from 5.1+/-0.7 to 8.5+/-0.9 kN/m2, P=0.006). Diabetes increased myocardial AGE deposition in patients with reduced LVEF (from 8.8+/-2.5 to 24.1+/-3.8 score/mm2; P=0.005) and less so in patients with normal LVEF (from 8.2+/-2.5 to 15.7+/-2.7 score/mm2, P=NS). CONCLUSIONS: Mechanisms responsible for the increased diastolic stiffness of the diabetic heart differ in heart failure with reduced and normal LVEF: Fibrosis and AGEs are more important when LVEF is reduced, whereas cardiomyocyte resting tension is more important when LVEF is normal.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Case-Control Studies
Diabetes Complications/ physiopathology
Diabetes Mellitus/physiopathology
Diastole
Female
Fibrosis
Glycosylation End Products, Advanced
Heart Failure/etiology/ pathology
Heart Ventricles/pathology
Humans
Male
Middle Aged
Muscle Tonus
Myocytes, Cardiac/ physiology
Stroke Volume
Megjelenés:Circulation. - 117 : 1 (2008), p. 43-51. -
További szerzők:Hamdani, Nazha Handoko, Martin Louis Falcao-Pires, Ines Musters, René J. Kupreishvili, Koba Ijsselmuiden, Alexander J. J. Schalkwijk, Casper G. Bronzwaer, Jean G. F. Diamant, Michaela Borbély Attila (1978-) (kardiológus) Velden, Jolanda, van der Stienen, Ger J. M. Laarman, Gerrit J. Niessen, Hans W. M. Paulus, Walter J.
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DOI
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7.

001-es BibID:BIBFORM023697
Első szerző:Kőszegi Zsolt (kardiológus, belgyógyász)
Cím:Giant Pulmonary Aneurysm Associated With Pulmonary Valve Agenesia / Zsolt Kőszegi, Nóra Homoródi, Annamária Bódi, Miklós Vaszily, Gusztáv Vajda, József Kollár and István Édes
Dátum:2005
ISSN:0009-7322
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Circulation. - 112 : 15 (2005), p. e263-e264. -
További szerzők:Homoródi Nóra (1974-) (kardiológus) Bódi Annamária (1957-) (kardiológus) Vaszily Miklós (1949-) (szívsebész) Vajda Gusztáv Kollár József (1950-) (radiológus) Édes István (1952-) (kardiológus)
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8.

001-es BibID:BIBFORM044122
035-os BibID:PMID: 23580744
Első szerző:Nagy-Baló Edina (kardiológus)
Cím:Transcranial Measurement of Cerebral Microembolic Signals during Pulmonary Vein Isolation : a Comparison of Two Ablation Techniques / Edina Nagy-Baló, Diana Tint, Marcell Clemens, Ildikó Beke, Katalin Réka Kovács, László Csiba, István Édes, Zoltán Csanádi
Dátum:2013
Megjegyzések:BACKGROUND: -Pulmonary vein isolation (PVI) has increasingly been used to cure atrial fibrillation, but concerns have recently been raised that subclinical brain damage may occur due to microembolization during these procedures. We compared the occurrence of bubble formation seen on intracardiac echocardiography (ICE) and the microembolic signals (MESs) detected by transcranial Doppler on the use of different ablation techniques and anticoagulation strategies. METHODS AND RESULTS: -This prospective study included 35 procedures in 34 consecutive patients (age: 52, SD: 12.8 years; female:male 9:25). PVI was performed with a cryoballoon and the conventional anticoagulation protocol (ACT>250 s) in 10 procedures (Group 1), with a multipolar duty-cycled radiofrequency pulmonary vein ablation catheter (PVAC) and the conventional anticoagulation protocol in 12 procedures (Group 2), and with a PVAC with an aggressive anticoagulation regime (ACT>320 s) in 13 procedures (Group 3). The mean total numbers of MESs detected during the procedures were 833.7 (SD: 727.4) in Group 1, 3142.6 (SD: 1736.4) in Group 2 and 2204.6 (SD: 1078.1) in Group 3 (p=0.0005). MESs were detected mostly during energy delivery in the PVAC groups, while a relatively even distribution of emboli formation was seen during cryoballoon ablations. A significant correlation was found in all groups between the degree of bubble formation on ICE and the number of MESs (p=0.0000). CONCLUSIONS: -Duty-cycled RF ablation is associated with significantly more MESs, even when more aggressive anticoagulation is applied. With both techniques most of these microemboli are gaseous in nature.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Circulation. Arrhythmia and Electrophysiology. - 6 : 3 (2013), p. 473-480. -
További szerzők:Tint, Diana Clemens Marcell (1979-) (kardiológus) Beke Ildikó (kardiológus) Czuriga-Kovács Katalin Réka (1981-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Édes István (1952-) (kardiológus) Csanádi Zoltán (1960-) (kardiológus)
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9.

001-es BibID:BIBFORM018115
Első szerző:Szerafin Tamás (szívsebész, mellkassebész)
Cím:Increased cyclooxygenase-2 expression and prostaglandin-mediated dilation in coronary arterioles of patients with diabetes mellitus / Szerafin T., Erdei N., Fülöp T., Pasztor T. E., Edes I., Koller A., Bagi Z.
Dátum:2006
ISSN:0009-7330
Megjegyzések:Based on findings of experimental models of diabetes mellitus (DM) showing increased expression of vascular cyclooxygenase-2 (COX-2), we hypothesized that in patients with DM changes in COX-2-dependent prostaglandin synthesis affect vasomotor responses of coronary arterioles. Arterioles were dissected from the right atrial appendages obtained at the time of cardiac surgery of patient with DM(+) or without documented diabetes DM(-). Isolated arterioles (89+/-15 microm in diameter) were cannulated and pressurized (at 80 mm Hg), and changes in diameter were measured with video microscopy. After spontaneous tone developed [DM(-): 32+/-7%; DM(+): 37+/-5%; P=NS], arteriolar responses to bradykinin were investigated. Dilations to bradykinin (0.1 nmol/L to 1 micromol/L) were significantly (P<0.05) greater in DM(+) than DM(-) patients (10 nmol/L: 77+/-10% versus 38+/-14%). In both groups, dilations were similar to the NO-donor, sodium nitroprusside. In arterioles of DM(+), but not those of DM(-), patients' bradykinin-induced dilations were reduced by the nonselective COX inhibitor indomethacin or by the selective COX-2 inhibitor NS-398 (DM(+) at 10 nmol/L: to 20+/-4% and 29+/-7%, respectively). Correspondingly, a marked COX-2 immunostaining was detected in coronary arterioles of DM(+), but not in those of DM(-) patients. We conclude that in coronary arterioles of diabetic patients bradykinin induces enhanced COX-2-derived prostaglandin-mediated dilation. These findings are the first to show that in humans diabetes mellitus increases COX-2 expression and dilator prostaglandin synthesis in coronary arterioles, which may serve to increase dilator capacity and maintain adequate perfusion of cardiac tissues.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Circulation Research. - 99 : 5 (2006), p. e12-e17. -
További szerzők:Erdei Nóra (1979-) (orvos) Fülöp Tibor (1957-) (kardiológus) Pásztorné Tóth Enikő (1966-) (laboratóriumi analitikus) Édes István (1952-) (kardiológus) Koller Ákos Bagi Zsolt (1974-) (orvos)
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