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001-es BibID:	BIBFORM112244
035-os BibID:	(scopus)85133578314 (wos)000822389000001
Első szerző:	Rácz Ágnes (orvos)
Cím:	Heart failure caused by Takayasu`s arteritis in the time of COVID-19 : a case report / Rácz Á. O., Szabó G. T., Erdei N., Győry F., Kolozsvári R. V.
Dátum:	2022
Megjegyzések:	The case of a 35-year-old female with heart failure is presented, where the symptoms overlap with the heterogeneous manifestations of coronavirus disease 2019 (COVID-19). Those similarities and a recent shift in priorities during the SARS-CoV-2 pandemic delayed the recognition of acute heart failure in this patient. During the differential diagnostic process, obliterative disease was discovered in the bilateral subclavian and right renal arteries, and the latter resulted in uncontrolled hypertension, which played a significant role in the development of heart failure. The aetiology of vascular alterations turned out to be Takayasu's arteritis. Diagnosing Takayasu's arteritis is typically not straightforward due to its nonspecific signs and symptoms. Therefore, it can be concluded from our case report that the rising incidence of COVID-19 and focus on ruling out infection can potentially defer alternative, but appropriate diagnostic tests, particularly for certain conditions like rare diseases. Early identification and intervention is especially important for treating acute heart failure, whereas delay increases the risk of severe complications and mortality.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok esettanulmány folyóiratcikk
Megjelenés:	ESC Heart Failure. - 9 : 5 (2022), p. 3602-3607. -
További szerzők:	Szabó Gábor Tamás (1982-) (kardiológus) Erdei Nóra (1979-) (orvos) Győry Ferenc (1969-) (kardiológus) Kolozsvári Rudolf (1976-) (kardiológus)
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001-es BibID:	BIBFORM108306
035-os BibID:	(Scopus)85147348324 (WoS)000922619800001
Első szerző:	Ráduly Arnold Péter
Cím:	Omecamtiv mecarbil augments cardiomyocyte contractile activity both at resting and systolic Ca2+ levels / Ráduly Arnold Péter, Tóth Attila, Sárkány Fruzsina, Horváth Balázs, Szentandrássy Norbert, Nánási Péter P., Csanádi Zoltán, Édes István, Papp Zoltán, Borbély Attila
Dátum:	2023
ISSN:	2055-5822
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	ESC heart failure. - 10 : 2 (2023), p. 1326-1335. -
További szerzők:	Tóth Attila (1971-) (biológus) Sárkány Fruzsina (1996-) (orvos) Horváth Balázs (1981-) (élettanász) Szentandrássy Norbert (1976-) (élettanász) Nánási Péter Pál (1956-) (élettanász) Csanádi Zoltán (1960-) (kardiológus) Édes István (1952-) (kardiológus) Papp Zoltán (1965-) (kardiológus, élettanász) Borbély Attila (1978-) (kardiológus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00043 GINOP ÚNKP-21-3 Egyéb TKP2020-IKA-04 Egyéb TKP2020-NKA-04 Egyéb 2020-4.1.1-TKP2020 Egyéb K 132623 OTKA NKFIH-K138090 Egyéb NKFIH-K142764 Egyéb NKFIH-FK128116 Egyéb
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001-es BibID:	BIBFORM117705
035-os BibID:	(Scopus)85180178281 (wos)001128612100001
Első szerző:	Solymossi Balázs
Cím:	Incidence and predictors of heart failure with improved ejection fraction category in a HFrEF patient population / Solymossi Balázs, Muk Balázs, Sepp Róbert, Habon Tamás, Borbély Attila, Heltai Krisztina, Majoros Zsuzsanna, Járai Zoltán, Vágány Dénes, Szatmári Ákos, Sziliczei Erzsébet, Bánfi-Bacsárdi Fanni, Nyolczas Noémi
Dátum:	2024
ISSN:	2055-5822
Megjegyzések:	Aims: The aim of the study was to assess the incidence and predictive factors of the development of heart failure with improved ejection fraction (HFimpEF) category during a 1 year follow-up period in a heart failure with reduced ejection fraction (HFrEF) patient population managed in a heart failure outpatient clinic. Methods and results: The study evaluated data from patients enrolled in the Hungarian Heart Failure Registry (HHFR). The incidence and predictive factors of the development of the HFimpEF category after 1 year follow-up were assessed in the group of patients who had HFrEF at baseline. We evaluated the incidence and predictors of the development of HFimpEF after a 1 year follow-up in relation to time since diagnosis of HFrEF in patients diagnosed within 3 months, between 3 months and 1 year, and beyond 1 year. The predictive factors of the development of HFimpEF were analysed using univariate and multivariate logistic regression analysis. Of the 833 HFrEF patients enrolled in the HHFR, the development of HFimpEF was observed in 162 patients (19.5%) during 1 year follow-up. In the whole patient population, independent predictors of the development of HFimpEF were female gender [odds ratio (OR): 1.73; 95% confidence interval (CI): 1.01?2.96; P < 0.05], non-ischaemic aetiology (OR: 1.95; 95% CI: 1.15?3.30; P < 0.05), and left ventricular end-diastolic diameter (LVEDD) <60 mm (OR: 2.04; 95% CI: 1.18?3.51; P < 0.05). The 1 year incidence of HFimpEF decreased in relation to time since diagnosis of HFrEF. The incidence of HFimpEF was 27.1% in patients diagnosed within 3 months, 18.4% in patients diagnosed between 3 months and 1 year, and 12.2% in patients diagnosed beyond 1 year. Non-ischaemic aetiology (OR: 4.76; 95% CI: 1.83?12.4; P < 0.01) and QRS width (OR: 0.81; 95% CI: 0.71?0.94; P < 0.01) for patients diagnosed within 3 months, LVEDD (OR: 0.54; 95% CI: 0.32?0.90; P < 0.05) and left atrial diameter ?45 mm (OR: 5.44; 95% CI: 1.45?20.4; P < 0.05) for patients diagnosed between 3 months and 1 year, and LVEDD < 67 mm (OR: 2.71; 95% CI: 1.07?6.88; P < 0.05) for patients diagnosed beyond 1 year were found to be independent predictive factors. Conclusions: In our study, in this HFrEF patient population managed in a heart failure outpatient clinic, the 1 year incidence of HFimpEF was found to be ~20%. The 1 year incidence of HFimpEF decreased in relation to time since diagnosis of HFrEF. The most important predictors of the development of HFimpEF were female sex, non-ischaemic aetiology, narrower QRS width, and smaller diameter of the left ventricle and left atrium.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Heart failure with improved ejection fraction Incidence Predictive factors Reverse remodelling
Megjelenés:	ESC heart failure. - 11 : 2 (2024), p. 783-794. -
További szerzők:	Muk Balázs Sepp Róbert Habon Tamás Borbély Attila (1978-) (kardiológus) Heltai Krisztina Majoros Zsuzsanna Járai Zoltán Vágány Dénes Szatmári Ákos Sziliczei Erzsébet Bánfi-Bacsárdi Fanni Nyolczas Noémi
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001-es BibID:	BIBFORM088246
Első szerző:	Szabó Gábor Tamás (kardiológus)
Cím:	Hypothetical dysfunction of the epithelial sodium channel may justify neurohumoral blockade in coronavirus disease 2019 / Szabó Gábor Tamás, Kiss Attila, Csanádi Zoltán, Czuriga Dániel
Dátum:	2021
ISSN:	2055-5822
Megjegyzések:	Since the outbreak of the COVID-19 pandemic, substantial effort has been made to understand the mechanism behind increased mortality in infected patients with pre-existing cardiovascular (CV) conditions. As the angiotensin-converting enzyme 2 (ACE2) on the host cell membrane serves as a known cellular entry point for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the use of renin-angiotensin-aldosterone system (RAAS) inhibitors seemed to pose an increased risk due to the potential upregulation of ACE2. In fact, initial assumptions concerning this issue were proven wrong when data regarding the beneficial effects of these drugs in SARS-CoV-2-infected cardiac patients surfaced. Here, we raise a novel hypothesis on the role of the epithelial sodium channel (ENaC) in the cascade of RAAS-mediated CV regulation in COVID-19 cases. Our assumption is based on the potentially reduced bioavailability of the endoprotease furin, leading to insufficient ENaC activation and consequently, RAAS upregulation. This unique mechanism may, in part, be responsible for the advantages of RAAS inhibition in the treatment of COVID-19 patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk EPITHELIAL SODIUM CHANNEL CORONAVIRUS DISEASE ACE2 COVID-19
Megjelenés:	ESC Heart Failure. - 8 : 1 (2021), p. 171-174. -
További szerzők:	Kiss Attila Csanádi Zoltán (1960-) (kardiológus) Czuriga Dániel (1982-) (kardiológus)
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