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001-es BibID:	BIBFORM040599
Első szerző:	Nieminen, Markku S.
Cím:	Effects of Levosimendan on the Energy Balance : Preclinical and Clinical Evidence / Markku S. Nieminen, Piero Pollesello, Gusztáv Vajda, Zoltán Papp
Dátum:	2009
Megjegyzések:	Levosimendan is a novel inodilator agent, which enhances myocardial performance without substantial changes in oxygen consumption. The combination of positive inotropic and vasodilator effects of levosimendan relates to its Ca-sensitizing and K channel opening effects. Levosimendan is one of the best documented pharmacological agents used in the management of acute heart failure syndromes. Interest in levosimendan has recently been renewed owing to its potential in supporting cardiac function in patients with ischemic heart disease and cardiogenic or septic shock. It has been also demonstrated that levosimendan can be used as a bridge therapy for the perioperative phase of cardiac surgery. The ability of levosimendan to improve myocardial function without substantially increasing oxygen consumption may appear paradoxical but is indeed possible via improved efficacy, not only with regard to the effects on the contractile apparatus of the cardiomyocytes but also when its composite hemodynamic effects are considered. The energy balance equation, therefore, should take into account the effect of levosimendan on all energy-consuming and energy-producing paths. Moreover, levosimendan-evoked KATP channel opening may possess favorable effects on mitochondrial adenosine triphosphate synthesis conferring cardioprotection during ischemic insults.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Cardiovascular Pharmacology and Therapeutics. - 53 : 4 (2009), p. 302-310. -
További szerzők:	Pollesello, Piero Vajda Gusztáv (1956-) (kardiológus) Papp Zoltán (1965-) (kardiológus, élettanász)
Pályázati támogatás:	K 68363 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM003764
Első szerző:	Pollesello, Piero
Cím:	The cardioprotective effects of levosimendan : preclinical and clinical evidence / Pollesello, P., Papp, Z.
Dátum:	2007
Megjegyzések:	Levosimendan, a drug used in the treatment of acute and decompensated heart failure, has positive inotropic and antistunning effects mediated by calcium sensitization of contractile proteins, and vasodilatory and antiischemic effects mediated via the opening of ATP-sensitive potassium channels in vascular smooth-muscle cells. Recently, it also has been shown to act on mitochondrial ATP-sensitive potassium (mitoKATP) channels, an action thought to protect the heart against ischemia-reperfusion damage. This finding has suggested a possible application for levosimendan in clinical situations in which preconditioning would be beneficial (eg, in pre- and perioperative settings in cardiac surgery). The demonstration that levosimendan can prevent or limit myocyte apoptosis via the activation of mitoKATP channels provides a potential mechanism whereby this agent might protect cardiac myocytes during episodes of acute heart failure. This finding may explain why short-term treatment with levosimendan may improve longer-term survival. The present article reviews the literature on the cardioprotective actions of levosimendan, with particular emphasis on its recently recognized effects on mitoKATP channels and the putative preconditioning effects of that action. A therapeutic approach to acute heart failure that includes a cardioprotective strategy could have a clinically meaningful benefit on disease progression beyond alleviation of symptoms
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Animals Calcium Cardiotonic Agents control drug effects Drug Evaluation,Preclinical Heart Failure Humans Hydrazones Ischemic Preconditioning,Myocardial methods Mitochondria,Heart Myocardial Reperfusion Injury pharmacology Potassium Channels prevention &amp Proteins Pyridazines Randomized Controlled Trials as Topic surgery
Megjelenés:	Journal of Cardiovascular Pharmacology. - 50 : 3 (2007), p. 257-263. -
További szerzők:	Papp Zoltán (1965-) (kardiológus, élettanász)
Internet cím:	elektronikus változat DOI
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