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001-es BibID:	BIBFORM015611
035-os BibID:	11451408
Első szerző:	Felszeghy Szabolcs Béla (fogorvos, anatómus, kötőszövetbiológus)
Cím:	The distribution pattern of the hyaluronan receptor CD44 during human toothdevelopment / Szabolcs Felszeghy, László Módis, Markku Tammi, Raija Tammi
Dátum:	2001
ISSN:	0003-9969 (Linking)
Megjegyzések:	The aim was to investigate the expression pattern of the major cell-surfacehyaluronan receptor CD44, as there are no existing data on its presence orabsence in human dental structures at different developmental stages.Immunohistochemical localization of CD44 was studied using a monoclonal antibody,H3, that specifically recognizes an epitope in the common backbone of all CD44isoforms. The dental lamina displayed a strong CD44 signal; the external enamelepithelium was negative. In the coronal region of the tooth germ the presecretoryameloblasts showed an intense reaction whereas the less differentiated innerenamel epithelial cells showed no signal at the cervical loop where they meet theexternal enamel epithelium. In the stellate reticulum a moderate reaction wasdetected. The secretory ameloblasts and the stratum intermedium showed a strongcell-surface CD44 signal. A strong signal was also observed on the odontoblastsand their processes. In the pulp, close to the odontoblastic layer, weaklabelling was seen in the walls of capillary vessels. The distribution of CD44 inthe human tooth germ corresponds to that of hyaluronan in most locations,suggesting that during tooth development this transmembrane protein plays animportant part in hyaluronan-mediated events.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban 0 (Antibodies, Monoclonal) 0 (Antigens, CD44) Age Factors Ameloblasts/chemistry/metabolism Antibodies, Monoclonal Antigens, CD44/analysis/biosynthesis Embryonic and Fetal Development Humans Immunohistochemistry Infant Infant, Newborn Odontoblasts/chemistry/metabolism Tooth Germ/chemistry/metabolism egyetemen (Magyarországon) készült közlemény
Megjelenés:	Archives of Oral biology. - 46 : 10 (2001), p. 939-945. -
További szerzők:	Módis László (1939-) (anatómus, kötőszövetbiológus) Tammi, Markku (kutatóorvos) Tammi, Raija (kutatóorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat elektronikus elérés DOI
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001-es BibID:	BIBFORM015607
035-os BibID:	15003543
Első szerző:	Felszeghy Szabolcs Béla (fogorvos, anatómus, kötőszövetbiológus)
Cím:	Expression of aquaporin isoforms during human and mouse tooth development / S. Felszeghy, L. Modis, P. Nemeth, G. Nagy, T. Zelles, P. Agre, J. Laurikkala, O. Fejerskov, I. Thesleff, S. Nielsen
Dátum:	2004
ISSN:	0003-9969 (Linking)
Megjegyzések:	Previously, we described the development of hyaluronan (HA) deposition in humantooth germ tissues that are consistent with water transport in different stagesof tooth development. The aquaporins (AQP) constitute a family of membrane waterchannels that are expressed in many organs. However, there are no data availableabout the expression pattern of aquaporin water channels in dental structures. Inthe present study we have characterised the expression of six different aquaporinisoforms (AQP1-5, AQP-9) in developing human and mouse tooth germs byimmunohistochemistry using isoform specific antibodies. In the "bell stage" AQP1was expressed in endothelial cells of small vessels whereas no other structuresof the tooth primordial were labeled. AQP2, AQP3 and AQP9 immunoreactivity wasnot observed in tooth germs, whereas strong AQP4 and AQP5 expression was observedin dental lamina, inner enamel epithelium, stratum intermedium, stellatereticulum and the outer enamel epithelium. Oral epithelium also exhibited AQP4and AQP5 immunolabeling. During development of the matrices of the dental hardtissues AQP4 and AQP5 immunostaining was observed in the odontoblasts and theirprocesses, as well as in the secretory ameloblast and their apical processes.Immunolabeling controls were negative. In conclusion, AQP4 and AQP5 are expressedin tooth germ tissues in early development in cells that previously have beenshown to express HA and/or CD44, indicating that AQP water channels may play arole for ECM hydration during tooth development.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban 0 (Aquaporins) Animals Aquaporins/metabolism Humans Immunohistochemistry Mice Mouth Mucosa/metabolism Tooth/growth & development/metabolism egyetemen (Magyarországon) készült közlemény Tooth Germ/growth & development/metabolism
Megjelenés:	Archives of oral biology. - 49 : 4 (2004), p. 247-257. -
További szerzők:	Módis László (1939-) (anatómus, kötőszövetbiológus) Németh Péter Nagy G. Zelles Tivadar Agre, P. Laurikkala, J. Fejerskov, O. Thesleff, Irma Nielsen, S.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat elektronikus elérés DOI
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001-es BibID:	BIBFORM015605
035-os BibID:	15721147
Első szerző:	Felszeghy Szabolcs Béla (fogorvos, anatómus, kötőszövetbiológus)
Cím:	The expression pattern of hyaluronan synthase during human tooth development / Felszeghy S., Meszar Z., Prehm P., Modis L.,
Dátum:	2005
ISSN:	0003-9969 (Linking)
Megjegyzések:	In previous studies, hyaluronan (HA) and its major cell surface receptor CD44have been suggested to play an important role during tooth development. HAsynthases (HASs) are the enzymes that polymerize hyaluronan. Data on theexpression pattern of HASs during tooth development is lacking and the aim of thepresent study was to investigate the localisation of HAS by immunohistochemistryin human tooth germs from different developmental stages. The distributionpattern of HAS in the various tissues of the "bell stage" tooth primordiacorresponded to that of hyaluronan in most locations: positive HASepithelium. On the stellate reticulum cells, moderate HAS signal was observed,similar to the layers of the oral epithelium, where faint HAS immunoreactivitywas detected. At the early phase of dental hard tissues mineralization, strongHAS immunoreactivity was detected in the odontoblasts and their processes, aswell as in the secretory ameloblasts and their apical processes and also, thepulpal mesenchymal cells. The HAS signals observed in odontoblasts andameloblasts gradually decreased with age. Our results demonstrate that hyaluronansynthesised locally by different dental cells and these results provideadditional indirect support to the suggestion that HA may contribute both to theregulation of tooth morphogenesis and dental hard tissue formation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban 9004-61-9 (Hyaluronic Acid) EC 2.4.1.17 (Glucuronosyltransferase) EC 2.4.1.212 (hyaluronan synthase) Ameloblasts/chemistry/enzymology Female Glucuronosyltransferase/analysis Humans Hyaluronic Acid/analysis Immunohistochemistry/methods Mouth Mucosa/chemistry/embryology Odontoblasts/chemistry/enzymology Odontogenesis/physiology Pregnancy Pregnancy Trimester, Second Pregnancy Trimester, Third Tooth Germ/*chemistry/enzymology egyetemen (Magyarországon) készült közlemény
Megjelenés:	Archives of oral biology. - 50 : 2 (2005), p. 175-179. -
További szerzők:	Mészár Zoltán Mihály (1977-) (agrármérnök) Prehm, P. Módis László (1939-) (anatómus, kötőszövetbiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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