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001-es BibID:	BIBFORM044742
035-os BibID:	PMID:23358586
Első szerző:	Karosi Tamás (fül-orr-gégész)
Cím:	The presence of CD209 expressing dendritic cells correlates with biofilm positivity in chronic rhinosinusitis with nasal polyposis / Tamás Karosi, Péter Csomor, Zoltán Hegyi, István Sziklai
Dátum:	2013
ISSN:	0937-4477
Megjegyzések:	Biofilm-positive cases of chronic rhinosinusitis with nasal polyposis (CRSwNP) may form a separate clinical entity, which is characterized by high recurrence rates and resistance against different therapeutic strategies. This can be explained by a special immunologic phenotype. Biofilm existence has been supposed to correlate with increased amount of dendritic cells that are responsible for antigen presentation in CRSwNP. A total of 20 patients with CRSwNP undergoing endoscopic sinus surgery (ESS) were analyzed. The negative control group consisted of ten patients undergoing septoplasty without CRSwNP. Three series of individual nasal polyps and control specimens were processed to hematoxylin-eosin (HE) and Gram staining and to CD209-specific immunofluorescent assay, respectively. Biofilm was detected in 13 of 20 patients (65 %) with CRSwNP and in none of the ten negative controls. The subepithelial layer of biofilm-positive nasal polyps displayed a statistically significant (p < 0.001) increase in the numbers of CD209-expressing dendritic cells compared to biofilm-negative specimens. It was found that biofilm detectability showed strong correlation to the architecture of respiratory mucosa and to the dominant inflammatory cell type of the subepithelial layer. Persisting bacterial biofilms may affect the type of antigen presentation and consecutive immune reactions in the subepithelial layer of nasal mucosa. This phenomenon may result in different inflammatory pathways with specific cytokine profile compared to biofilm-negative cases. Co-existence of bacterial biofilms and dominant pattern of dendritic cells suggest a biofilm-associated immunologic phenotype in CRSwNP. This can explain the mucosal changes, functional disorders and therapy resistance featuring CRSwNP.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	European Archives of Oto-Rhino-Laryngology. - 270 : 9 (2013), p. 2455-2463. -
További szerzők:	Csomor Péter (1984-) (biotechnológus) Hegyi Zoltán (1983-) (molekuláris biológus) Sziklai István (1954-) (fül-orr-gégész)
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001-es BibID:	BIBFORM001624
Első szerző:	Karosi Tamás (fül-orr-gégész)
Cím:	Expression of measles virus receptors in otosclerotic, non-otosclerotic and in normal stapes footplates / Karosi Tamás, Jókay István, Kónya József, Petkó Mihály, Z. Szabó László, Sziklai István
Dátum:	2007
Megjegyzések:	Otosclerosis is a bone remodeling disorder of complex etiology. Persistent measles virus infection of the otic capsule could increase the expression level of measles virus receptors (CD46) on the osteoclasts and endothelial cells of the otosclerotic foci. Presence of measles virus RNA was demonstrated in the footplates of histologically diagnosed otosclerotic patients by RT-PCR; however, no reports were available about the CD46 expression pattern and level in otosclerosis. Nucleic acid was extracted from stapes footplates of clinically otosclerotic patients (N = 116). Genomic RNA of measles virus was amplified by RT-PCR. Amplification results were correlated with postoperative histologic and CD46 specific immunhistologic findings. Among 116 stapes fixation cases, 87 otosclerotic stapes contained measles virus RNA. Histology for virus negative stapes (N = 29) represented degenerative disorders with heterogeneous histopathology. Active otosclerosis was featured by increased numbers of osteoclasts showing strong CD46 expression. In virus negative, non-otosclerotic stapes fixation and in normal stapes footplates weak CD46 immunoreaction was demonstrated on the osteocytes and fibroblasts. In otosclerosis, it is reasonable to assume that measles virus increases the expression level of its own cellular receptor. Furthermore, intensive CD46 reaction could relate to active virus replication and continuous receptor internalisation. Otosclerosis is a disease of disturbed osteoid turnover due to persistent measles virus infection and special CD46 receptor pattern of the otic capsule.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban footplate measles virus
Megjelenés:	European Archives of Oto-Rhino-Laryngology 264 : 6 (2007), p. 607-613. -
További szerzők:	Jókay István (1954-) (fül-orr-gégész) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Petkó Mihály (1943-) (orvos, neurobiológus) Z. Szabó László Sziklai István (1954-) (fül-orr-gégész)
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001-es BibID:	BIBFORM029983
Első szerző:	Székely György (neurobiológus)
Cím:	Comparative anatomy of the central representation of the facial nerve / G. Székely, C. Matesz
Dátum:	1994
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	European archives of oto-rhino-laryngology. - Suppl (1994), p. S3-S5. -
További szerzők:	Matesz Klára (1949-) (anatómus, neurobiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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