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1.

001-es BibID:BIBFORM029080
Első szerző:Antal Miklós (orvos, anatómus)
Cím:Development of calbindin-D28k immunoreactive neurons in the embryonic chick lumbosacral spinal cord / Miklós Antal, Erika Polgár
Dátum:1993
Megjegyzések:The development of immunoreactivity for the calcium-binding protein calbindin-D28k (CaB) was investigated in the embryonic and hatched chick lumbosacral spinal cord. CaB-immunoreactive neurons were revealed in the dorsal and ventral horns as well as in the intermediate grey matter from early stages of neuronal development. CaB immunoreactivity was first detected in large neurons in the presumptive dorsal horn at embryonic day 5, while small neurons in the lateral dorsal horn were the last to appear, at embryonic day 10. We have identified and traced the morphological maturation of six CaB-immunoreactive cell groups, three in the dorsal horn and three in the ventral horn. In the dorsal horn these groups were (1) large neurons in the lateral dorsal horn (laminae I and IV), (2) small neurons in the lateral dorsal horn (lamina II), and (3) small neurons in the medial dorsal horn (lamina III). All three groups were present throughout the entire length of the lumbosacral spinal cord and showed persistent CaB immunoreactivity. In the ventral horn, CaB-immunoreactive neurons were classified into the following three categories: (1) Neurons dorsal to the lateral motor column (lamina VII). These neurons were present exclusively in the upper lumbosacral segments (LS1-3), and they showed steady CaB immunoreactivity during their maturation. (2) Neurons at the dorsomedial aspect of the lateral motor column (at the border of laminae VII and IX). This population of neurons was characteristic of the lower segments of the lumbosacral cord (LS5-7) and presented transient CaB expression. (3) Neurons within the lateral motor column (lamina IX). These neurons were dispersed throughout the length of the lumbosacral spinal cord. They were three to four times more numerous in the upper than in the lower lumbosacral segments, and their numbers declined throughout LS1-7 as the animal matured. The characteristic features of the development of neurons immunoreactive for CaB are discussed and correlated with previous neuroanatomical and physiological studies concerning sensory and motor functions of the developing chick spinal cord.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) észült közlemény
Megjelenés:European Journal of Neuroscience. - 5 : 7 (1993), p. 782-794. -
További szerzők:Polgár Erika
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2.

001-es BibID:BIBFORM029094
Első szerző:Antal Miklós (orvos, anatómus)
Cím:Expression of hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 in axon terminals of peptidergic nociceptive primary sensory neurons in the superficial spinal dorsal horn of rats / Antal, M., Papp, I., Bahaerguli, N., Veress, G., Vereb, G.
Dátum:2004
Megjegyzések:Hyperpolarization-activated cyclic nucleotide-gated cation channel proteins (HCN1-4), which are potentially able to modulate membrane excitability, are abundantly expressed by neurons in spinal dorsal root ganglia (DRG). In the present experiment, we investigated whether HCN2 protein is confined exclusively to the perikarya of DRG neurons or is transported from the somata to the central axons of DRG neurons that terminate in the spinal dorsal horn. Using immunohistochemical methods, we have demonstrated that laminae I-IIo of the superficial spinal dorsal horn of the adult rat spinal cord show a strong punctate immunoreactivity for HCN2. Dorsal rhizotomy resulted in a complete loss of immunostaining in the dorsal horn, suggesting that HCN2 is confined to axon terminals of primary afferents. In double labelling immunohistochemical studies, we have also shown that HCN2 widely co-localizes with calcitonin gene-related peptide, but is almost completely segregated from isolectin-B4 binding, indicating that HCN2 is primarily expressed in peptidergic nociceptive primary afferents. The expression of HCN2 in central terminals of peptidergic primary afferents was also verified with electron microscopy. Utilizing the pre-embedding nanogold method, we found that HCN2 is largely confined to axon terminals with dense-core vesicles. Within these terminals, some of the silver grains marking the accurate location of HCN2 molecules were associated with the cell membrane, and others were scattered in the axoplasm. Within the cell membrane, HCN2 was found almost exclusively in extrasynaptic locations. The results suggest that HCN2 may contribute to the modulation of membrane excitability of nociceptive primary afferent terminals in the spinal dorsal horn.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The European Journal of Neuroscience 19 : 5 (2004), p. 1336-1342. -
További szerzők:Papp Ildikó (1976-) (biológus) Bahaerguli, Niyazi Veress Gábor (1971-) (neurobiológus) Vereb György (1965-) (biofizikus, orvos)
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elektronikus változat
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3.

001-es BibID:BIBFORM028807
Első szerző:Antal Miklós (orvos, anatómus)
Cím:The application of cobalt labelling to electron microscopic investigations of serial sections / Antal M.
Dátum:1984
ISSN:0165-0270
Megjegyzések:The cobalt labelling technique can be applied to ultrathin serial sections and subsequent electron microscopical investigations with the following modifications: a prolonged, up to 12 h, fixation of the tissue in aldehydes; a shortened, 15 min, postfixation in OsO4; embedding in soft resin block by using a higher proportion of plasticizer in the polimerizing mixture; mounting of 5 micrometers thick serial sections between two layers of Agar-Agar coatings; performing the intensification of the Agar section-Agar sandwich with a physical developer containing a low percentage of the reductive agent; reembedding selected thick sections for ultrathin serial sectioning and staining with uranile acetate and lead citrate. The technique unambiguously shows all labelled profiles, and preserves the fine structural details of the surrounding tissues.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neuroscience Methods. - 12 : 1 (1984), p. 69-77. -
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4.

001-es BibID:BIBFORM004385
Első szerző:Antal Miklós (orvos, anatómus)
Cím:Numbers, densities, and colocalization of AMPA- and NMDA-type glutamate receptors at individual synapses in the superficial spinal dorsal horn of rats / Miklós Antal, Yugo Fukazawa, Mária Eördögh, Dóra Muszil, Elek Molnár, Makoto Itakura, Masami Takahashi, Ryuichi Shigemoto
Dátum:2008
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Neuroscience. - 28 : 39 (2008), p. 9692-9701. -
További szerzők:Fukazawa, Yugo Eördögh Mária Muszil Dóra Molnár Elek Itakura, Makoto Takahashi, Masami Shigemoto, Ryuichi
Internet cím:elektronikus változat
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5.

001-es BibID:BIBFORM054375
Első szerző:Bánki Eszter
Cím:Molecular Mechanisms Underlying the Nephroprotective Effects of PACAP in Diabetes / Eszter Banki, Krisztina Kovacs, Daniel Nagy, Tamas Juhasz, Peter Degrell, Katalin Csanaky, Peter Kiss, Gabor Jancso, Gabor Toth, Andrea Tamas, Dora Reglodi
Dátum:2014
ISSN:0895-8696
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Molecular Neuroscience 54 : 3 (2014), p. 300-309. -
További szerzők:Kovács Krisztina (Pécs) Nagy Dániel Juhász Tamás (1976-) (biológus, orvosbiológus) Degrell Péter Csanaky Katalin Kiss Péter (Pécs) Jancsó Gábor Tóth Gábor Tamás Andrea (Idegtudomány) (Pécs) Reglődi Dóra (Idegtudományok)
Pályázati támogatás:K104984
OTKA
108596
OTKA
TÁMOP-4.2.2.A-11/1/KONV-2012-0024
TÁMOP
Bolyai Ösztöndíj
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6.

001-es BibID:BIBFORM029495
Első szerző:Birinyi András (anatómus, neurobiológus)
Cím:The extent of the dendritic tree and the number of synapses in the frog motoneuron / Birinyi A., Antal M., Wolf E., Székely G.
Dátum:1992
ISSN:0953-816X
Megjegyzések:Frog motoneurons were intracellularly labelled with cobaltic lysine in the brachial and the lumbar segments of the spinal cord, and the material was processed for light microscopy in serial sections. With the aid of the neuron reconstruction system NEUTRACE, the dendritic tree of neurons was reconstructed and the length and surface area of dendrites measured. The surface of somata was determined with the prolate - oblate average ellipsoid calculation. Corrections were made for shrinkage and for optical distortion. The mean surface area of somata was 6710 microm2; lumbar motoneurons were slightly larger than brachial motoneurons. The mean length of the combined dendritic tree of brachial neurons was 29 408 microm and that of lumbar neurons 46 806 microm. The mean surface area was 127 335 microm2 in brachial neurons, and 168 063 microm2 in lumbar neurons. The soma - dendrite surface area ratio was 3 - 5% in most cases. Dendrites with a diameter of </= 1.0 microm constituted approximately 75% of the combined dendritic length in most of the neurons. Unlike in the cat, there was no correlation between the size of stem dendrites and the extent of daughter branches. From the synaptic density estimated in earlier electron microscope investigations of frog motoneuron dendrites (Antal et al., J. Neurocytol., 15, 303 - 310, 1986; 21, 34 - 49, 1992), and from the present data, the number of synapses on the dendritic tree was calculated. The calculations indicated 26 949 synapses on the smallest and 61 519 synapses on the largest neuron if the synaptic density was multiplied by the length of the dendritic tree. If the synaptic density was multiplied by the surface area of the dendritic tree the calculation yielded 23 337 synapses for the smallest and 60 682 synapses for the largest neuron. More than 60% of the combined surface area of dendrites was >600 microm from the soma. This suggests that about two-thirds of the synapses impinged upon distant dendrites >600 microm from the soma. The efficacy of synapses at these large distances is investigated on model neurons in the accompanying paper
Tárgyszavak:Orvostudományok Természettudományok Biológiai tudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal Of Neuroscience. - 4 : 11 (1992), p. 1003-1012. -
További szerzők:Antal Miklós (1951-) (orvos, anatómus) Wolf Ervin (1961-) (fizikus, neurobiológus) Székely György (1926-2017) (neurobiológus)
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7.

001-es BibID:BIBFORM080931
035-os BibID:(WoS)000483415800005 (Scopus)85071715733
Első szerző:Chistiakova, Marina
Cím:Distinct Heterosynaptic Plasticity in Fast Spiking and Non-Fast-Spiking Inhibitory Neurons in Rat Visual Cortex / Marina Chistiakova, Vladimir Ilin, Matvey Roshchin, Nicholas Bannon, Alexey Malyshev, Zoltán Kisvárday, Maxim Volgushev
Dátum:2019
ISSN:0270-6474 1529-2401
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Neuroscience. - 39 : 35 (2019), p. 6865-6878. -
További szerzők:Ilin, Vladimir Roshchin, Matvey Bannon, Nicholas Malyshev, Alexey Kisvárday Zoltán (1957-) (biológus, neurobiológus) Volgushev, Maxim
Pályázati támogatás:NAP-2-2017-1.2.1-NKP-00002
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8.

001-es BibID:BIBFORM069485
Első szerző:Farkas József
Cím:Early Neurobehavioral Development of Mice Lacking Endogenous PACAP / Farkas J., Sandor B., Tamas A., Kiss P., Hashimoto H., Nagy A. D., Fulop B. D., Juhasz T., Manavalan S., Reglodi D.
Dátum:2017
Megjegyzések:Pituitary adenylate cyclase activating polypeptide (PACAP) is a multifunctional neuropeptide. In addition to its diverse physiological roles, PACAP has important functions in the embryonic development of various tissues, and it is also considered as a trophic factor during development and in the case of neuronal injuries. Data suggest that the development of the nervous system is severely affected by the lack of endogenous PACAP. Short-term neurofunctional outcome correlates with long-term functional deficits; however, the early neurobehavioral development of PACAP-deficient mice has not yet been evaluated. Therefore, the aim of the present study was to describe the postnatal development of physical signs and neurological reflexes in mice partially or completely lacking PACAP. We examined developmental hallmarks during the first 3 weeks of the postnatal period, during which period most neurological reflexes and motor coordination show most intensive development, and we describe the neurobehavioral development using a complex battery of tests. In the present study, we found that PACAP-deficient mice had slower weight gain throughout the observation period. Interestingly, mice partially lacking PACAP weighed significantly less than homozygous mice. There was no difference between male and female mice during the first 3 weeks. Some other signs were also more severely affected in the heterozygous mice than in the homozygous mice, such as air righting, grasp, and gait initiation reflexes. Interestingly, incisor teeth erupted earlier in mice lacking PACAP. Motor coordination, shown by the number of foot-faults on an elevated grid, was also less developed in PACAP-deficient mice. In summary, our results show that mice lacking endogenous PACAP have slower weight gain during the first weeks of development and slower neurobehavioral development regarding a few developmental hallmarks.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Knockout
Neurodevelopment
Neuropeptide
Reflex
Trophic factor
Megjelenés:Journal of molecular neuroscience. - 61 : 4 (2017), p. 468-478. -
További szerzők:Sándor Balázs Tamás Andrea (Idegtudomány) (Pécs) Kiss Péter (Pécs) Hashimoto, Hitoshi Nagy András Dávid Fülöp Balázs Dániel (Orvosi alapkutatások) Juhász Tamás (1976-) (biológus, orvosbiológus) Manavalan, Sridharan Reglődi Dóra (Idegtudományok)
Pályázati támogatás:K104984
OTKA
K119759
OTKA
GINOP-2.3.2-15-2016-00050
GINOP
TAMOP 4.2.4.A/2-11-1-2012-0001
TÁMOP
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9.

001-es BibID:BIBFORM040492
Első szerző:Ferraguti, Francesco
Cím:Metabotropic Glutamate Receptor 8-Expressing Nerve Terminals Target Subsets of GABAergic Neurons in the Hippocampus / Francesco Ferraguti, Thomas Klausberger, Philip Cobden, Agnes Baude, J. David B. Roberts, Peter Szucs, Ayae Kinoshita, Ryuichi Shigemoto, Peter Somogyi, Yannis Dalezios
Dátum:2005
ISSN:0270-6474
Megjegyzések:Presynaptic metabotropic glutamate receptors (mGluRs) show a highly selective expression and subcellular location in nerve terminals modulating neurotransmitter release. We have demonstrated that alternatively spliced variants of mGluR8, mGluR8a and mGluR8b, have an overlapping distribution in the hippocampus, and besides perforant path terminals, they are expressed in the presynaptic active zone of boutons making synapses selectively with several types of GABAergic interneurons, primarily in the stratum oriens. Boutons labeled for mGluR8 formed either type I or type II synapses, and the latter were GABAergic. Some mGluR8-positive boutons also expressed mGluR7 or vasoactive intestinal polypeptide. Interneurons strongly immunopositive for the muscarinic M2 or the mGlu1 receptors were the primary targets of mGluR8-containing terminals in the stratum oriens, but only neurochemically distinct subsets were innervated by mGluR8-enriched terminals. The majority of M2-positive neurons were mGluR8 innervated, but a minority, which expresses somatostatin, was not. Rare neurons coexpressing calretinin and M2 were consistently targeted by mGluR8-positive boutons. In vivo recording and labeling of an mGluR8-decorated and strongly M2-positive interneuron revealed a trilaminar cell with complex spike bursts during theta oscillations and strong discharge during sharp wave/ripple events. The trilaminar cell had a large projection from the CA1 area to the subiculum and a preferential innervation of interneurons in the CA1 area in addition to pyramidal cell somata and dendrites. The postsynaptic interneuron type-specific expression of the high-efficacy presynaptic mGluR8 in both putative glutamatergic and in identified GABAergic terminals predicts a role in adjusting the activity of interneurons depending on the level of network activity.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neuroscience. - 25 : 45 (2005), p. 10520-10536. -
További szerzők:Klausberger, Thomas Cobden, Philip Baude, Agnes Roberts, J. David B. Szűcs Péter (1974-) (kutatóorvos) Kinoshita, Ayae Shigemoto, Ryuichi Somogyi Péter Dalezios, Yannis
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10.

001-es BibID:BIBFORM057633
Első szerző:Fournier, Julien
Cím:Hidden Complexity of Synaptic Receptive Fields in Cat V1 / Julien Fournier, Cyril Monier, Manuel Levy, Olivier Marre, Katalin Sári, Zoltán F. Kisvárday, Yves Frégnac
Dátum:2014
ISSN:0270-6474
Megjegyzések:In the primary visual cortex (V1), Simple and Complex receptive fields (RFs) are usually characterized on the basis of the linearity of the cell spiking response to stimuli of opposite contrast. Whether or not this classification reflects a functional dichotomy in the synaptic inputs to Simple and Complex cells is still an open issue. Here we combined intracellular membrane potential recordings in cat V1 with 2D dense noise stimulation to decompose the Simple-like and Complex-like components of the subthreshold RF into a parallel set of functionally distinct subunits. Results show that both Simple and Complex RFs exhibit a remarkable diversity of excitatory and inhibitory Complex-like contributions, which differ in orientation and spatial frequency selectivity from the linear RF, even in layer 4 and layer 6 Simple cells. We further show that the diversity of Complex-like contributions recovered at the subthreshold level is expressed in the cell spiking output. These results demonstrate that the Simple or Complex nature of V1 RFs does not rely on the diversity of Complex-like components received by the cell from its synaptic afferents but on the imbalance between the weights of the Simple-like and Complex-like synaptic contributions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuroscience. - 34 : 16 (2014), p. 5515-5528. -
További szerzők:Monier, Cyril Levy, Manuel Marre, Olivier Sári Katalin Kisvárday Zoltán (1957-) (biológus, neurobiológus) Frégnac, Yves
Pályázati támogatás:2010-IST-FETPI 269921
FP7
MTA-DE
MTA
Idegtudományi Kutatócsoport
EM-646 KTIA-NAP 13-1-2013-0001
Egyéb
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11.

001-es BibID:BIBFORM103634
035-os BibID:(WOS)000472082700006 (Scopus)85051646952
Első szerző:Fülöp Balázs Dániel (Orvosi alapkutatások)
Cím:Altered Notch Signaling in Developing Molar Teeth of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Deficient Mice / B. D. Fulop, B. Sandor, E. Szentleleky, E. Karanyicz, D. Reglodi, B. Gaszner, R. Zakany, H. Hashimoto, T. Juhasz, A. Tamas
Dátum:2019
ISSN:0895-8696
Megjegyzések:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with neuroprotective and neurotrophic effects. This suggests its influence on the development of teeth, which are, similarly to the nervous system, ectoderm and neural crest derivatives. Our earlier studies have shown morphological differences between wild-type (WT) and PACAP-deficient mice, with upregulated sonic hedgehog (SHH) signaling in the lack of PACAP. Notch signaling is a key element of proper tooth development by regulating apoptosis and cell proliferation. In this study, our main goal was to evaluate the possible effects of PACAP on Notch signaling pathway. Immunohistochemical staining was performed of Notch receptors (Notch1, 2, 3, 4), their ligands [deltalike protein (DLL)1, 3, 4, Jagged1, 2], and intracellular target molecules [CSL (CBF1 humans/Su (H) Drosophila/LAG1 Caenorhabditis elegans transcription factor); TACE (TNF-? converting enzyme), NUMB] in molar teeth of 5-day-old WT, and homozygous and heterozygous PACAP-deficient mice. We measured immunopositivity in the enamel-producing ameloblasts and dentin-producing odontoblasts. Notch2 receptor and DLL1 expression were elevated in ameloblasts of PACAPdeficient mice compared to those in WT ones. The expression of CSL showed similar results both in the ameloblasts and odontoblasts. Jagged1 ligand expression was elevated in the odontoblasts of homozygous PACAP-deficient mice compared to WT mice. Other Notch pathway elements did not show significant differences between the genotype groups. The lack of PACAP leads to upregulation of Notch pathway elements in the odontoblast and ameloblast cells. The underlying molecular mechanisms are yet to be elucidated; however, we propose SHH-dependent and independent processes. We hypothesize that this compensatory upregulation of Notch signaling by the lack of PACAP could represent a salvage pathway in PACAP-deficient animals.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
PACAP-deficient mice
Notch signaling
DLL1, 3, 4, Jagged1, 2
Notch1, 2, 3, 4
CSL
TACE
NUMB
Development of molar tooth
Megjelenés:Journal of Molecular Neuroscience. - 68 : 3 (2019), p. 377-388. -
További szerzők:Sándor Balázs Szentléleky Eszter (fogászat) Karanyicz Edina Reglődi Dóra (Idegtudományok) Gaszner Balázs (Neuroanatómia) Zákány Róza (1963-) (anatómus-, kötőszövetbiológus) Hashimoto, Hitoshi Juhász Tamás (1976-) (biológus, orvosbiológus) Tamás Andrea (Idegtudomány) (Pécs)
Pályázati támogatás:2.3.2-15-2016-00050 BPEPSYS^
GINOP
3.6.3-VEKOP-16-15 2017-00008
EFOP
3.6.2-16-2017-00008
EFOP
3.6.1- 16.2016.00004
EFOP
4.2.4.A/2-11-1-2012-0001
TAMOP
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12.

001-es BibID:BIBFORM032423
Első szerző:Girard, F.
Cím:Gene expression analysis in the parvalbumin-immunoreactive PV1 nucleus of the mouse lateral hypothalamus / Girard, F., Meszar, Z., Marti, C., Davis, F. P., Celio, M.
Dátum:2011
ISSN:0953-816X
Megjegyzések:A solitary, elongated cluster of parvalbumin-immunoreactive neurons has been previously observed in the rodent ventrolateral hypothalamus. However, the function of this so-called PV1 nucleus is unknown. In this article, we report the results of an unbiased, broad and in-depth molecular characterization of this small, compact group of neurons. The Allen Brain Atlas database of in situ hybridization was screened in order to identify genes expressed in the PV1-nucleus-containing area of the hypothalamus, and those that might be co-expressed with parvalbumin. Although GABA is the principal neurotransmitter in parvalbumin-expressing cells in various other brain areas, we found that PV1 neurons express the vesicular glutamate transporter (VGlut) VGlut2-encoding gene Slc17a6 and are negative for the glutamic acid decarboxylase 1 (GAD1) gene. These cells also express the mRNA for the neuropeptides Adcyap1 and possibly Nxph4, express several types of potassium and sodium channels, are under the control of the neurotransmitter acetylcholine, bear receptors for the glial-derived neurotrophic factor, and produce an extracellular matrix rich in osteopontin. The PV1 nucleus is thus composed of glutamatergic nerve cells, expressing some typical markers of long-axon, projecting neurons (e.g. VGlut2), but also co-expressing genes typical of short-axon GABA neurons (e.g. a variety of potassium channels). Hence, neurons of the PV1 nucleus combine physiological characteristics of interneurons with those of projection neurons.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal Of Neuroscience. - 34 : 12 (2011), p. 1934-1943. -
További szerzők:Mészár Zoltán Mihály (1977-) (agrármérnök) Marti, C. Davis, F. P. Celio, M.
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