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001-es BibID:	BIBFORM079731
035-os BibID:	(WoS)000473358900002 (Scopus)85069927512
Első szerző:	Lampé István (fogszakorvos)
Cím:	Investigation of silver nanoparticles on titanium surface created by ion implantation technology / István Lampé, Dezső Beke, Sándor Biri, István Csarnovics, Attila Csik, Zsuzsanna Dombrádi, Péter Hajdu, Viktória Hegedűs, Richárd Rácz, István Varga, Csaba Hegedűs
Dátum:	2019
ISSN:	1178-2013
Megjegyzések:	Objectives: Using dental Ti implants has become a well-accepted and used method for replacing missing dentition. It has become evident that in many cases peri-implant inflammation develops. The objective was to create and evaluate the antibacterial effect of silver nanoparticle (Ag-NP) coated Ti surfaces that can help to prevent such processes if applied on the surface of dental implants. Methods: Annealing I, Ag ion implantation by the beam of an Electron Cyclotron Resonance Ion Source (ECRIS), Ag Physical Vapor Deposition (PVD), Annealing II procedures were used, respectively, to create a safely anchored Ag-NP layer on 1x1 cm2, Grade 2 titanium samples. The antibacterial effect was evaluated by culturing Staphylococcus aureus (ATCC 29213) on the surfaces of the samples for 8 hours, and comparing the results to that of glass as control and of pure titanium samples. Alamar Blue assay was carried out to check cytotoxicity. Results: It was proved that silver nanoparticles were present on the treated surfaces. The average diameter of the particles was 58 nm, with a 25 nm deviation and Gaussian distribution, the the filling factor was 25%. Antibacterial evaluation revealed that the nanoparticle covered samples had an antibacterial effect of 64.6% that was statistically significant. Tests also proved that the nanoparticles are safely anchored to the titanium surface and are not cytotoxic. Conclusion: Creating a silver nanoparticle layer can be an option to add antibacterial features to the implant surface and to help in the prevention of peri-implant inflammatory processes. Recent studies demonstrated that silver nanoparticles can induce pathology in mammal cells, thus safe fixation of the particles is essential to prevent them from getting into the circulation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk implants peri-implant inflammation oxyde layer cytocompatibility antibacterial effect physical vapor deposition geometrical model
Megjelenés:	International Journal of Nanomedicine. - 2019 : 14 (2019), p. 4709-4721. -
További szerzők:	Beke Dezső László (1945-) (fizikus) Biri Sándor Csarnovics István (1986-) (fizikus) Csik Attila (1975-) (fizikus) Dombrádi Zsuzsanna Rita (1983-) (molekuláris biológus, mikrobiológus) Hajdu Péter (1988-) (gyorsító üzemeltető mérnök) Hegedűs Viktória (1986-) (fogorvos) Rácz Richárd (1985-) (fizikus) Varga István (1974-) (fogszakorvos) Hegedűs Csaba (1953-) (fogszakorvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00041 GINOP GINOP-2.3.2-15-2016-00022 GINOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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