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001-es BibID:	BIBFORM013305
Első szerző:	Radics Tünde (egyetemi adjunktus, fogszakorvos)
Cím:	Interleukin-6 and granulocytemacrophage colony-stimulating factor in apical periodontitis : correlation with clinical and histologic findings of the involved teeth / T. Radics, C. Kiss, I. Tar, I. J. Márton
Dátum:	2003
ISSN:	0902-0055
Megjegyzések:	Apical periodontitis is characterized by the presence of immunocompetent cells producing a wide variety of inflammatory mediators. Releasing cytokines with long-range action, such as interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating factor (GM-CSF), apical periodontitis may induce changes in remote organs of the host. This study quantified the levels of IL-6 and GM-CSF in symptomatic and asymptomatic human periradicular lesions. Lesions were also characterized by size and histologic findings. Tissue samples were homogenized and supernatants were assayed using an enzyme-linked immunosorbent assay (ELISA). Correlations between cytokine levels and characteristic features (as single variables) of the lesions were analysed. There was a trend for higher levels of IL-6 and GM-CSF in symptomatic than in asymptomatic lesions, but the difference was not significant. Levels also tended to be higher in large than in small lesions, in polymorphonuclear (PMN) cell-rich than in PMN cell-poor samples, and in epithelialized than in non-epithelialized lesions. Significantly higher levels of IL-6 (778.1 +/- 220.5 pg/microg) and GM-CSF (363.3 +/- 98.4 pg/microg) were found in samples coincidentally possessing symptomatic and epithelialized features than in asymptomatic, small, PMN cell-poor, non-epithelialized lesions (IL-6: 45.2 +/- 13.1 pg/microg and GM-CSF: 135.1 +/- 26.4 pg/microg). These results suggest that symptomatic lesions containing epithelial cells represent an immunologically active stage of apical periodontitis, whereas asymptomatic, small, PMN cell-poor, non-epithelialized lesions represent healing apical lesions.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban cytokines granulocytemacrophage colony-stimulating factor interleukin-6 periodontitis
Megjelenés:	Oral Microbiology And Immunology. - 18 : 1 (2003), p. 9-13. -
További szerzők:	Kiss Csongor (1956-) (hematológus, onkológus) Tar Ildikó (1967-) (fogszakorvos) Márton Ildikó (1954-) (fogszakorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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