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001-es BibID:	BIBFORM085697
035-os BibID:	(WoS)000447090400106 (Scopus)85051113271
Első szerző:	Nagy Károly (népegészségügyi felügyelő)
Cím:	Interlaboratory evaluation of the genotoxic properties of pencycuron, a commonly used phenylurea fungicide / Nagy Károly, Zheng Congying, Bolognesi Claudia, Ádám Balázs
Dátum:	2019
ISSN:	0048-9697
Megjegyzések:	Pencycuron, a phenylurea-type antifungal agent, is used in agriculture worldwide for inhibiting the growth of various fungal pathogens of crops. Pencycuron residues were found in vegetables, soil and drinking water. Accordingly, both occupational and consumer exposure can be expected and may be significant. However, human toxicity studies on its genotoxic, mutagenic or carcinogenic potential are lacking. Therefore, a collaborative study was performed in two laboratories to investigate whether pencycuron exposure can induce DNA damage. The genotoxic effect of 0-100??g/ml pencycuron in in vitro cultures of human mononuclear white blood cells (MWBCs) and human hepatocytes (HepG2) was detected by cytokinesis-block micronucleus assay and comet assay. The combined results of the two labs showed a dose-dependent DNA damage detected by micronucleus frequency, which reached statistical significance at 100??g/ml concentration after 21-h exposure in HepG2 cells (p?=?0.048). Significant genotoxic effect could also be observed in the comet assay from 50??g/ml concentration in MWBCs, and at 100??g/ml concentration in HepG2 cells in one lab. Nevertheless, this finding was not confirmed by the other lab in HepG2 cells, where Fpg-dependent oxidative DNA damage could also not be detected. The results indicate that pencycuron may have DNA-damaging potential as well as point out inter-laboratory variability that calls for further studies to confirm the genotoxicity of this fungicide.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Science Of The Total Environment. - 647 (2019), p. 1052-1057. -
További szerzők:	Zheng, Congying Bolognesi, Claudia Ádám Balázs (1973-) (megelőző orvostan és népegészségtan szakorvos)
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001-es BibID:	BIBFORM103564
035-os BibID:	(WoS)000863090700018 (Scopus)85137072456 (Cikkazonosító)158305
Első szerző:	Pál László (népegészségügyi szakember, egészségfejlesztő)
Cím:	Health and economic gain attributable to the introduction of the World Health Organization's drinking water standard on arsenic level in Hungary : a nationwide retrospective study on cancer occurrence and ischemic heart disease mortality / Pál László, Jenei Tibor, McKee Martin, Kovács Nóra, Vargha Márta, Bufa-Dőrr Zsuzsanna, Muhollari Teuta, Bujdosó Marozsán Orsolya, Sándor János, Szűcs Sándor
Dátum:	2022
ISSN:	0048-9697
Megjegyzések:	The World Health Organization (WHO) estimates that 140 million individuals are at risk from consumption of drinking water containing arsenic at concentrations above the WHO guideline value of 10 ?g/l. Arsenic mitigation is considered to be the most effective way to prevent arsenic related diseases. After joining the European Union, Hungary implemented a Drinking Water Quality Improvement Programme (DWQIP) to reduce levels of arsenic in drinking water below the WHO guideline value. But what impact did this have on health? We estimated the change in lifetime excess skin, lung, and bladder cancer risks and mortality from ischaemic heart disease (IHD) associated with chronic arsenic intake among those exposed before (2004?2007) and after (2014?2017) the implementation of DWQIP. A populationbased risk assessment approach was used to assess lifetime excess cancer risk applying two scenarios for lung and bladder cancers. The economic benefits of the DWQIP were estimated by the combination of cost of illness and value per statistical life methods. Compared to the period before the DWQIP, its implementation was associated with a significant reduction in arsenic in drinking water [median: 3.0 ?g/l interquartile range (IQR): 1.5?12.0 ?g/l to median: 2.15 ?g/l IQR: 1.0?5.79 ?g/l]. The two scenarios were estimated to be associated with 225.2 and 35.9 fewer cancer cases each year. The number of annually prevented IHD deaths was estimated to be 88.9. It was estimated that the benefits of the DWQIP will outweigh its costs. We conclude that reducing arsenic levels in drinking water to 10.0 ?g/l resulted in significant health and economic benefits. Our study goes beyond the existing research, offering both new insights into the impact of arsenic mitigation and providing a methodological template for similar studies in the many parts of the world that have yet to reduce arsenic exposure.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Arsenic exposure WHO drinking water standard Arsenic mitigation Cancer risk assessment Mortality from ischemic heart disease Public health and economic benefits
Megjelenés:	Science Of The Total Environment. - 851 (2022), p. 1-11. -
További szerzők:	Jenei Tibor (1963-) (programtervező informatikus) McKee, Martin Kovács Nóra (1989-) (népegészségügyi szakember) Vargha Márta Bufa-Dőrr Zsuzsanna Muhollari, Teuta Bujdosó Orsolya (1992-) (népegészségügyi szakember) Sándor János (1966-) (orvos-epidemiológus) Szűcs Sándor (1958-) (biokémikus, vegyész)
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