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1.

001-es BibID:BIBFORM055859
Első szerző:Beck Zoltán (molekuláris biológus, mikrobiológus)
Cím:Interactions between HTLV type I and HIV type 1 in monocyte-derived macrophages cultured in vitro / Beck Zoltán, Szabó Judit, Liu Xiangdong, Bácsi Attila, Ebbesen Peter, D. Tóth Ferenc
Dátum:2001
Tárgyszavak:Természettudományok Biológiai tudományok idézhető absztrakt
Megjelenés:AIDS Research And Human Retroviruses. - 17 : Suppl. 1 (2001), p. 51. -
További szerzők:Szabó Judit (1963-) (szakorvos, klinikai mikrobiológus) Liu, Xiangdong Bácsi Attila (1967-) (immunológus) Ebbesen, Peter Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász)
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2.

001-es BibID:BIBFORM055864
Első szerző:Beck Zoltán (molekuláris biológus, mikrobiológus)
Cím:Induction of full replication cycle of human cytomegalovirus by the Tax protein of HTLV-I in CD4+T cells / Beck Zoltán, Bácsi Attila, Nagy Etelka, Csoma Eszter, D. Toth Ferenc
Dátum:2003
Tárgyszavak:Természettudományok Biológiai tudományok idézhető absztrakt
Megjelenés:AIDS Research And Human Retroviruses. - 19 : Suppl. 1 (2003), p. 80. -
További szerzők:Bácsi Attila (1967-) (immunológus) Nagy Etelka Csoma Eszter (1978-) (molekuláris biológus, mikrobiológus) Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász)
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3.

001-es BibID:BIBFORM019698
Első szerző:Szabó Judit (szakorvos, klinikai mikrobiológus)
Cím:Reciprocal interactions between human cytomegalovirus and human T cell leukemia-lymphoma virus type I in monocyte-derived macrophages cultured in vitro / Szabó J., Bácsi A., Andirkó I., Kiss J., Nemes J., D. Tóth F.
Dátum:1998
ISSN:0889-2229
Megjegyzések:Infection of macrophages with human cytomegalovirus (HCMV) has been shown to be nonlytic and exclusively cell associated. Human T cell leukemia-lymphoma virus type I (HTLV-I) is capable of establishing productive infection in macrophages. We studied the interactions between HCMV and HTLV-I in monocyte-derived macrophages cultured in vitro. We found that coinfection of macrophages with HCMV and HTLV-I significantly enhanced HCMV replication, resulting in release of infectious HCMV from dually infected cells. On the other hand, HCMV inhibited HTLV-I replication in macrophages coinfected with both viruses. Reciprocal interactions between HCMV and HTLV-I were mediated by their trans-acting proteins. Results of transfection studies demonstrated that the tax gene product of HTLV-I alone was capable of upregulating HCMV production. In a transient gene expression assay the immediate-early 2 (IE2) protein of HCMV alone could inhibit HTLV-I replication, whereas the IE1 protein, which had no effect by itself, produced a synergistic inhibitory effect together with the IE2 protein. Results from this study suggest that in vivo double infection of macrophages with HCMV and HTLV-I may contribute to the dissemination of HCMV infection in patients suffering from HTLV-I-associated T cell leukemia-lymphoma.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Aids Research and Human Retroviruses. - 14 : 8 (1998), p. 699-709. -
További szerzők:Bácsi Attila (1967-) (immunológus) Andirkó István Kiss J. Nemes J. Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász)
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4.

001-es BibID:BIBFORM019688
Első szerző:Szabó Judit (szakorvos, klinikai mikrobiológus)
Cím:Differential patterns of interaction between HIV type 1 and HTLV type I in monocyte-derived macrophages cultured in vitro : implications for in vivo coinfection with HIV type 1 and HTLV type I / Szabó J., Beck Z., Csomán É., Liu X., Andirkó I., Kiss J., Bácsi A., Ebbesen P., D. Tóth F.
Dátum:1999
ISSN:0889-2229
Megjegyzések:The interaction between human immunodeficiency virus type 1 (HIV-1) and human T cell leukemia-lymphoma virus type I (HTLV-I) has generated substantial interest. However, there is disagreement on the in vivo consequences of the double infection. We investigated the interactions between HIV-1 and HTLV-I in monocyte-derived macrophages cultured in vitro . For study, the T cell-tropic strain IIIB and the macrophagetropic strain Ada-M of HIV-1 were used. The HTLV-I was prepared from the supernatants of the virus-producing MT-2 cell line. We found that coinfection of macrophages with T cell-tropic HIV-1 and HTLV-I significantly enhanced HIV-1 replication, whereas double infection of the cells with macrophage-tropic HIV-1 and HTLV-I resulted in marked upregulation of HTLV-I production. Stimulatory interactions between HIV1 and HTLV-I were mediated by their trans -acting proteins. Results of study on nuclear translocation of proviral DNA showed that the tax gene product of HTLV-I was able to facilitate the nuclear import of the reversetranscribed HIV-1IIIB DNA. In contrast, the HIV-1 Tat protein did not increase the intranuclear trafficking of HTLV-I DNA, which suggests another mechanism for HTLV-I enhancement by the tat gene product. In conclusion, this study provides possible mechanisms whereby coinfection of an individual with HIV-1 and HTLV-I may influence the clinical outcome of double infection.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Aids Research And Human Retroviruses. - 15 : 18 (1999), p. 1653-1666. -
További szerzők:Beck Zoltán (1970-) (molekuláris biológus, mikrobiológus) Csomán Éva Liu, Xiangdong Andirkó István Kiss Jolán Bácsi Attila (1967-) (immunológus) Ebbesen, Peter Tóth Ferenc, D. (1940-2004) (mikrobiológus, élettanász)
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5.

001-es BibID:BIBFORM019702
Első szerző:Tóth Ferenc, D. (mikrobiológus, élettanász)
Cím:Bidirectional enhancing activities between human cell leukemia-lymphoma virus type I and human cytomegalovirus in human term syncytiotrophoblast cells cultured in vitro / D. Tóth F., Aboagye-Mathiesen G., Szabó J., Liu X., Mosborg-Petersen P., Kiss J., Hager H., Zdravkovic M., Andirkó I., Aranyosi J., Ebbesen P.
Dátum:1995
ISSN:0889-2229
Megjegyzések:The syncytiotrophoblast layer of the human placenta has an important role in limiting transplacental viral spread from mother to fetus. Human cytomegalovirus (HCMV) is capable of establishing a latent infection in syncytiotrophoblast cells, with restriction of gene expression to immediate-early and early proteins. We analyzed the extent of replication of human T cell leukemia-lymphoma virus type I (HTLV-I) in human term syncytiotrophoblasts infected with HTLV-I alone or coinfected with HTLV-I and HCMV. Although syncytiotrophoblasts could be infected with cell-free HTLV-I, no viral protein expression was found in the singly infected cells. On the contrary, coinfection of the cells with HTLV-I and HCMV resulted in simultaneous replication of both viruses. Bidirectional enhancing activities between HTLV-I and HCMV were mediated primarily by the Tax and immediate-early proteins, respectively. The stimulatory effect of HTLV-I Tax on HCMV replication appeared to be mediated partly by tumor necrosis factor beta and transforming growth factor beta-1. We observed formation of pseudotypes with HTLV-I nucleocapsids within HCMV envelopes, whereas HCMV was not pseudotyped by HTLV-I envelopes in dually infected syncytiotrophoblast cells. Our data suggest that in vivo dual infection of syncytiotrophoblast cells with HTLV-I and HCMV may facilitate the transplacental transmission of both viruses.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Aids Research And Human Retroviruses. - 11 : 12 (1995), p. 1495-1507. -
További szerzők:Aboagye-Mathiesen, George Szabó Judit (1963-) (szakorvos, klinikai mikrobiológus) Liu, Xiangdong Mosborg-Petersen, P. Kiss Jolán Hager Henrik Zdravkovic, Milan Andirkó István Aranyosi János (1963-) (szülész-nőgyógyász) ifj. Ebbesen, Peter
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