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001-es BibID:	BIBFORM040216
Első szerző:	Hernádi Zoltán (szülész-nőgyógyász, klinikai onkológus)
Cím:	Duration of HPV-associated risk for high-grade cervical intraepithelial neoplasia / Hernádi Z., Gazdag L., Szőke K., Sápy T., Krasznai Z. T., Kónya J.
Dátum:	2006
ISSN:	0301-2115
Megjegyzések:	OBJECTIVE: To evaluate the duration of high-risk HPV-associated cancer risk. STUDY DESIGN: Patients who had had a routine diagnostic Hybrid Capture Tube Test (HCT) due to squamous cell abnormalities of the uterine cervix were followed-up until the endpoint of histologically diagnosed cervical intraepithelial neoplasia (CIN). RESULTS: Six hundred and thirty-eight women were followed during a cumulative follow-up of 16,423 patient months. The adjusted relative risk associated with the positive HR-HCT test for high-grade CIN/52.0 (20.9-19.2)/ proved to be higher than that of the cytological atypia/5.44 (2.52-11.77)/. At the end of the 30 months of follow-up the crude and adjusted risks for CIN2+ were 214.3 (28.4-1615.7) and 196.7 (25.4-1525.2), respectively in the HPV 16/18 group, and after 30 months, the crude and adjusted RR decreased to 57.6 (10.4-318.9) and 29.2 (5.02-170.0). In the groups of other high-risk types and possibly high-risk types the general tendency was the same. However, new CIN2+ cases were not detected after the 30th month of follow-up in these later groups. CONCLUSIONS: HPV16/18 associated relative risk is nearly 200 times higher than that of the HPV negative population and an outstanding risk persists with duration of about 30 months. The risk is manifested in progression to high-grade CIN lesions mainly within a 2 years interval after the first detection of HPV 16/18 infection.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	European Journal Of Obstetrics Gynecology And Reproductive Biology. - 125 : 1 (2006), p. 114-119. -
További szerzők:	Gazdag László Szőke Krisztina Sápy Tamás (1970-) (szülész-nőgyógyász) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Kónya József (1964-) (szakorvos, klinikai mikrobiológus)
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001-es BibID:	BIBFORM028354
Első szerző:	Hernádi Zoltán (szülész-nőgyógyász, klinikai onkológus)
Cím:	Role of human papillomavirus (HPV) testing in the follow-up of patients after treatment for cervical precancerous lesions / Hernádi Z., Szőke K., Sápy T., Krasznai Z. T., Soós G., Veress G., Gergely L., Kónya J.
Dátum:	2005
Megjegyzések:	To evaluate the role of human papillomavirus (HPV) testing in post-treatment follow-up of patients after therapeutic excision of the cervix due to positive screening tests. STUDY DESIGN: A hospital-based retrospective analysis was performed with prospective collection of patient data of women screened for cervical cancer at a Gynecologic Outpatient Clinic. Patients after therapeutic excision due to positive screening results were identified and followed up with HPV testing and serial cytology. RESULTS: After 61 treatment for cervicalis intraepithelialis neoplasia (CIN), high-risk HPV infection was detected during the post-treatment follow-up at 18 cases (29.5%), 10 of them had persisting cytological atypia (positive predictive value (PPV): 56%), 5 developed CIN (PPV: 28%). When the HPV test was negative (43 patients) in the post-treatment period, neither CIN nor persisting cytological atypia developed (negative predictive value (NPV): 100%) during 1201 patient months (median 26 months). CONCLUSIONS: A negative HPV test eliminates the risk of recurrent disease after treatment for CIN.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban HPV
Megjelenés:	European Journal of Obstetrics & Gynecology and Reproductive Biology. - 118 : 2 (2005), p. 229-234. -
További szerzők:	Szőke Krisztina Sápy Tamás (1970-) (szülész-nőgyógyász) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Soós Györgyike (1959-) (pathológus) Veress György (1966-) (biológus, mikrobiológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Kónya József (1964-) (szakorvos, klinikai mikrobiológus)
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001-es BibID:	BIBFORM036779
035-os BibID:	PMID:9138961
Első szerző:	Póka Róbert (szülész-nőgyógyász, klinikai onkológus)
Cím:	HPV- and node status in cervical cancer long-term results / R. Póka, J. Czeglédy
Dátum:	1997
ISSN:	0301-2115 (Linking)
Megjegyzések:	OBJECTIVE: To evaluate prognostic significance of HPV-status in cervical cancerand to compare that with the prognostic significance of lymph-node status.METHODS: Cervical cancer biopsy specimens from primaries and, in surgical cases,from pelvic lymph-nodes too were analysed for the presence of humanpapillomavirus type 16 DNA-sequences using PCR technique. The management ofsurgical cases with two exceptions included Wertheim's hysterectomy predominantlywith preoperative local radiotherapy and also with postoperative local andexternal beam radiotherapy depending on the histology. Non-surgical cases weretreated with combined local and external radiotherapy to pelvic fields. RESULTS:Patients have been followed up for an average of 37 months after treatmentranging between 0 and 102 months. The mean progression-free survival time ofsurgical and non-surgical cases were 43 and 28 months, respectively. Patientswith HPV-16 positive biopsies from the cervical primary had an averageprogression-free survival of 37 months, the same as those with HPV-16 negativecervical biopsies. Those patients who were found to carry HPV-16 DNA in theirsurgically removed pelvic lymph-nodes had an average of 27 monthsprogression-free survival. The mean progression-free survival amonghistologically node-positive and node-negative surgical cases were 23 and 42months, respectively. The mean progression-free survival time of node-positivecases with HPV-16 positive cervical primary was 7.5 months while that of patientswith HPV-16 negative cervical biopsy was 38 months. Among histologicallynode-negative patients, HPV-16 positive and negative cases had an averageprogression-free survival time of 38 and 46 months, respectively. CONCLUSIONS:Among those under investigation the most important factors to predictprogression-free survival were surgically amenable disease, histologicallynegative pelvic lymph-nodes and HPV-16 negative cervical biopsies, though thislatter one proved significant only among surgical cases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Combined Modality Therapy Disease-Free Survival Female Follow-Up Studies Humans Lymphatic Metastasis Neoplasm Staging Papillomaviridae/isolation & purification Prognosis Uterine Cervical Neoplasms/mortality/pathology/surgery/virology egyetemen (Magyarországon) készült közlemény
Megjelenés:	European journal of obstetrics, gynecology, and reproductive biology. - 71 : 2 (1997), p. 169-172. -
További szerzők:	Czeglédy Judit (1944-) (virológus)
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001-es BibID:	BIBFORM001546
Első szerző:	Sápy Tamás (szülész-nőgyógyász)
Cím:	Age-specific prevalence of high-risk human papillomavirus infection in a Hungarian female population with positive cytology / Sápy Tamás, Póka Róbert, Szarka Krisztina, Kónya József, Huga Sándor, Hernádi Zoltán
Dátum:	2008
Megjegyzések:	Patients with positive screening results and persistence of high-risk human papillomavirus (HPV) infection represent the population at the highest risk for developing cervical cancer. To describe the epidemiology in this high-risk population, data were collected and analysed at the referral centre for patients with positive cytology. STUDY DESIGN: Between January 1997 and December 2002 the authors performed 3480 virus identifications using the Digene Hybrid Capture((R)) system in a female population with positive cytology at cervical cancer screening. Age-specific prevalence data were evaluated and compared between the age groups by running the chi(2) and Pearson chi(2) tests. Subgroup analysis was performed to estimate monthly clearance rates among eligible women with positive HR-HPV results. RESULTS: Low-risk (LR), high-risk (HR) and double infections were detected in 91 cases (2.6%), 1072 cases (30.8%) and 59 cases (1.7%), respectively. A significantly higher incidence of high-, rather than low-risk HPV infections was found in all age groups (p<0.001). Also, in this high-risk population with positive screening a significant decrease was detected in the prevalence of both high- and low-risk infections beyond 35 years of age (p<0.001). However, the decline in the HR-HPV types occurred later than in the case of LR infections, and HR-HPV was of remarkable frequency in the older age groups, which might represent both incidental and prevalent cases. Subgroup analysis for estimating monthly clearance rates revealed no significant differences between the various age groups and between women with various cytology results. CONCLUSIONS: In a population with positive cytology the prevalence of HPV drops with age while the relative frequency of high-risk HPV infection remains at the same level as that of the youngest age group.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban humán papillomavírus
Megjelenés:	European Journal of Obstetrics and Gynecology and Reproductive Biology 138 : 2 (2008), p. 194-198. -
További szerzők:	Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Huga Sándor (1965-) (szülész-nőgyógyász szakorvos) Hernádi Zoltán (1948-) (szülész-nőgyógyász, klinikai onkológus)
Internet cím:	elektronikus változat DOI elektronikus változat
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