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1.

001-es BibID:BIBFORM008925
Első szerző:Bágyi Kinga (fogszakorvos)
Cím:Role of pathogenic oral flora in postoperative pneumonia following brain surgery / Bágyi Kinga, Haczku Angela, Márton Ildikó, Szabó Judit, Gáspár Attila, Andrási Melinda, Varga Imre, Tóth Judit, Klekner Álmos
Dátum:2009
Megjegyzések:Post-operative pulmonary infection often appears to result from aspiration of pathogens colonizing the oral cavity. It was hypothesized that impaired periodontal status and pathogenic oral bacteria significantly contribute to development of aspiration pneumonia following neurosurgical operations. Further, the prophylactic effects of a single dose preoperative cefazolin on the oral bacteria were investigated. Methods: A matched cohort of 18 patients without postoperative lung complications was compared to 5 patients who developed pneumonia within 48 hours after brain surgery. Patients waiting for elective operation of a single brain tumor underwent dental examination and saliva collection before surgery. Bacteria from saliva cultures were isolated and periodontal disease was scored according to type and severity. Patients received 15 mg/kg cefazolin intravenously at the beginning of surgery. Serum, saliva and bronchial secretion were collected promptly after the operation. The minimal inhibitory concentrations of cefazolin regarding the isolated bacteria were determined. The actual antibiotic concentrations in serum, saliva and bronchial secretion were measured by capillary electrophoresis upon completion of surgery. Bacteria were isolated again from the sputum of postoperative pneumonia patients. Results: The number and severity of coexisting periodontal diseases were significantly greater in patients with postoperative pneumonia in comparison to the control group (p = 0.031 and p = 0.002, respectively). The relative risk of developing postoperative pneumonia in high periodontal score patients was 3.5 greater than in patients who had low periodontal score (p < 0.0001). Cefazolin concentration in saliva and bronchial secretion remained below detectable levels in every patient. Conclusion: Presence of multiple periodontal diseases and pathogenic bacteria in the saliva are important predisposing factors of postoperative aspiration pneumonia in patients after brain surgery. The low penetration rate of cefazolin into the saliva indicates that its prophylactic administration may not be sufficient to prevent postoperative aspiration pneumonia. Our study suggests that dental examination may be warranted in order to identify patients at high risk of developing postoperative respiratory infections.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
pneumonia
egyetemen (Magyarországon) készült közlemény
Megjelenés:BMC Infectious Diseases. - 9 (2009), p. 104-113. -
További szerzők:Haczku Angela Márton Ildikó (1954-) (fogszakorvos) Szabó Judit (1963-) (szakorvos, klinikai mikrobiológus) Gáspár Attila (1970-) (vegyész, kémikus) Andrási Melinda (1979-) (gyógyszerész) Varga Imre (1960-) (tüdőgyógyász) Tóth Judit (1958-) (onkológus szakorvos) Klekner Álmos (1970-) (idegsebész)
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2.

001-es BibID:BIBFORM062414
Első szerző:Ebrahimi, Fatemeh
Cím:Asymptomatic faecal carriage of ESBL producing Enterobacteriaceae in Hungarian healthy individuals and in long-term care applicants : a shift towards CTX-M producers in the community / Fatemeh Ebrahimi, Julianna Mózes, Júlia Mészáros, Ágnes Juhász, László Majoros, Krisztina Szarka, Gábor Kardos
Dátum:2016
Megjegyzések:Background: Faecal carriage of extended-spectrum beta- lactamase (ESBL) producing Enterobacteriaceae28 in healthy individuals was examined and compared to previous results obtained in such individuals a few29 years earlier.30 Methods: Faecal samples from 779 individuals screened for employment purposes and from 22531 applicants to long-term care (LTC) were screened between November 2013 and May 2014.32 Results: The overall rate of fecal carriage was 3.0% (30/1004). The carriage rate was significantly higher33 in applicants for LTC (5.3% vs. 2.3%; p=0.019). All isolates carried CTX-M ESBLs, with an34 overwhelming dominance of blaCTX-M-15 (84.4%) in both groups and in both E. coli and Klebsiella35 pneumoniae.36 Conclusions: The prevalences were comparable to those in the earlier study, but a marked decrease of the37 diversity of ESBL genes in E. coli from the employment screening group was found, suggesting that the38 ESBL-producing isolates originating from diverse sources are being replaced by highly successful blaCTX39M-15 producing strains.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
extended-spectrum beta-lactamases, Klebsiella pneumoniae, Escherichia coli
Megjelenés:Infectious Diseases 48 : 7 (2016), p. 557-559. -
További szerzők:Mózes Julianna (1982-) (orvosdiagnosztikai laboratóriumi analitikus, okleveles népegészségügyi szakember) Mészáros Júlia Juhász Ágnes Majoros László (1966-) (szakorvos, klinikai mikrobiológus) Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus) Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus)
Pályázati támogatás:TÁMOP 4.2.4. A/2-11-1-2012-0001
TÁMOP
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3.

001-es BibID:BIBFORM050849
Első szerző:Iturriza-Gomara, Miren
Cím:Rotavirus surveillance in europe, 2005-2008 : web-enabled reporting and real-time analysis of genotyping and epidemiological data / M. Iturriza-Gómara, T. Dallman, K. Bányai, B. Böttiger, J. Buesa, S. Diedrich, L. Fiore, K. Johansen, N. Korsun, A. Kroneman, M. Lappalainen, B. László, L. Maunula, J. Matthinjnssens, S. Midgley, Z. Mladenova, M. Poljsak-Prijatelj, P. Pothier, F. M. Ruggeri, A. Sanchez-Fauquier, E. Schreier, A. Steyer, I. Sidaraviciute, A. N. Tran, V. Usonis, M. Van Ranst, A. de Rougemont, J. Gray
Dátum:2009
ISSN:0022-1899
Megjegyzések:The first European rotavirus surveillance network, EuroRotaNet, comprising 16 laboratories in 15 European countries, has been established. Methods. Fecal samples from gastroenteritis cases positive for group A rotavirus antigen were collected from multiple European countries from 2005 to mid-2008 and were subjected to G and P genotyping. Epidemiological data collected included age, sex, geographical location, setting, dates of onset and sample collection, and clinical symptoms. Results. A total of 8879 rotavirus-positive samples were characterized: 2129 cases were from the 2005-2006 season, 4030 from the 2006-2007 season, and 2720 from the ongoing 2007-2008 season. A total of 30 different G and P type combinations of strains circulated in the region from 2005 through 2008. Of these strains, 90% had genotypes commonly associated with human infections-G1P[8], G2P[4], G3P[8], G4P[8], and G9P[8]-and 1.37% represented potential zoonotic introductions. G1P[8] remained the most prevalent genotype in Europe as a whole, but the incidence of infection with G1P[8] rotavirus strains was <50% overall, and all 3 seasons were characterized by a significant diversity of cocirculating strains. The peak incidence of rotavirus infection occurred from January through May, and 81% of case patients were aged <2.5 years. Conclusions. Data gathered through EuroRotaNet will provide valuable background information on the rotavirus strain diversity in Europe before the introduction of rotavirus vaccines, and the network will provide a robust method for surveillance during vaccine implementation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Infectious Diseases. - 200 : Suppl. 1 (2009), p. S215-S221. -
További szerzők:Dallman, T. Bányai Krisztián Böttiger, B. Buesa, J. Diedrich, S. Fiore, L. Johansen, K. Korsun, N. Kroneman, A. Lappalainen, Marit László Brigitta (1983-) (molekuláris biológus, mikrobiológus) Maunula, L. Matthijnssens, Jelle Midgley, S. Mladenova, Z. Poljsak-Prijatelj, M. Pothier, P. Ruggeri, F. M. Sanchez-Fauquier, A. Schreier, Elisabeth Steyer, A. Sidaraviciute-Ivaskeviciene, I. Tran, A. N. Usonis, V. Ranst, M., Van Rougemont, A., de Gray, J.
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4.

001-es BibID:BIBFORM077691
035-os BibID:(cikkazonosító)253
Első szerző:Kolozsvári László Róbert (háziorvos)
Cím:Patient-related factors, antibiotic prescribing and antimicrobial resistance of the commensal Staphylococcus aureus and Streptococcus pneumoniae in a healthy population - Hungarian results of the APRES study / László Róbert Kolozsvári, József Kónya, John Paget, Francois G. Schellevis, János Sándor, Gergő József Szőllősi, Szilvia Harsányi, Zoltán Jancsó, Imre Rurik
Dátum:2019
ISSN:1471-2334
Megjegyzések:Background: Antimicrobial resistance (AMR) is an increasing public health problem worldwide. We studied some patient-related factors that might influence the antimicrobial resistance. and whether the volume of antibiotic prescribing of the primary care physicians correlate with the antibiotic resistance rates of commensal nasal Staphylococcus aureus and Streptococcus pneumoniae. Methods: The socio-demographic questionnaires, the antibiotic prescription and resistance data of commensal nasal S. aureus and S. pneumoniae were collected in the 20 participating Hungarian practices of the APRES study. Multivariate logistic regression analyses were performed on the patient-related data and the antimicrobial resistance of the S. aureus and S. pneumoniae on individual, patient level. Ecological analyses were performed with Spearman's rank correlations at practice level, the analyses were performed in the whole sample (all practices) and in the cohorts of primary care practices taking care of adults (adult practices) or children (paediatric practices). Results: According to the multivariate model, age of the patients significantly influenced the antimicrobial resistance of the S. aureus (OR = 0.42, p = 0.004) and S. pneumoniae (OR = 0.89, p < 0.001). Living with children significantly increased the AMR of the S. pneumoniae (OR = 1.23, p = 0.019). In the cohorts of adult or paediatric practices, neither the age nor other variables influenced the AMR of the S. aureus and S. pneumoniae. At practice level, the prescribed volume of penicillins significantly correlated with the resistance rates of the S. aureus isolates to penicillin (rho = 0.57, p = 0.008). The volume of prescribed macrolides, lincosamides showed positive significant correlations with the S. pneumoniae resistance rates to clarithromycin and/or clindamycin in all practices (rho = 0.76, p = 0.001) and in the adult practices (rho = 0.63, p = 0.021). Conclusions: The age is an important influencing factor of antimicrobial resistance. The results also suggest that there may be an association between the antibiotic prescribing of the primary care providers and the antibiotic resistance of the commensal S. aureus and S. pneumoniae. The role of the primary care physicians in the appropriate antibiotic prescribing is very important to avoid the antibiotic resistance.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Antimicrobial resistance
Antibacterial resistance
Commensal
Healthy population
Patient-related factors
Staphylococcus aureus
Streptococcus pneumoniae
Megjelenés:BMC Infectious Diseases. - 19 (2019), p. 1-8. -
További szerzők:Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Paget, John Schellevis, Francois G. Sándor János (1966-) (orvos-epidemiológus) Szőllősi Gergő József (1991-) (népegészségügyi ellenőr, népegészségügyi szakember) Kolozsváriné Harsányi Szilvia (1983-) (okleveles egészségpolitikai szakértő) Jancsó Zoltán (1973-) (orvos, háziorvos szakorvos, foglalkozás-orvostan szakorvos) Rurik Imre (1953-) (háziorvos, foglalkozás-egészségügyi szakorvos, urológus)
Pályázati támogatás:223083
FP7
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5.

001-es BibID:BIBFORM040239
Első szerző:Majoros László (szakorvos, klinikai mikrobiológus)
Cím:Slow response of invasive Candida krusei infection to amphotericin B in a clinical time-kill study / Majoros L., Szegedi I., Kardos G., Erdész C., Kónya J., Kiss C.
Dátum:2006
ISSN:0934-9723
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal Of Clinical Microbiology & Infectious Diseases. - 25 : 12 (2006), p. 803-806. -
További szerzők:Szegedi István (1969-) (hematológus, onkológus, nefrológus) Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) Erdész Csaba Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Kiss Csongor (1956-) (hematológus, onkológus)
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6.

001-es BibID:BIBFORM059207
Első szerző:Paholcsek Melinda (molekuláris biológus, genetikus)
Cím:Combining standard clinical methods with PCR showed improved diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia / Melinda Paholcsek, Gabor Fidler, Jozsef Konya, Laszlo Rejto, Gabor Mehes, Evelin Bukta, Juergen Loeffler, Sandor Biro
Dátum:2015
ISSN:1471-2334
Megjegyzések:Background: We assessed the diagnostic value of standard clinical methods and combined biomarker testing(galactomannan assay and polymerase chain reaction screening) in a prospective case?control study to detectinvasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia.Methods: In this observational study 162 biomarker analyses were performed on samples from 27 febrile neutropenicepisodes. Sera were successively screened for galactomannan antigen and for Aspergillus fumigatus specific nucleic acidtargets. Furthermore thoracic computed tomography scanning was performed along with bronchoscopy with lavagewhen clinically indicated. Patients were retrospectively stratified to define a case-group with "proven" or "probable"invasive pulmonary aspergillosis (25.93 %) and a control-group of patients with no evidence for of invasive pulmonaryaspergillosis (74.07 %). In 44.44 % of episodes fever ceased in response to antibiotic treatment (group II). Empiricalantifungal therapy was administered for episodes with persistent or relapsing fever (group I). 48.15 % of patientsdied during the study period. Postmortem histology was pursued in 53.85 % of fatalities.Results: Concordant negative galactomannan and computed tomography supported by a polymerase chainreaction assay were shown to have the highest discriminatory power to exclude invasive pulmonary aspergillosis.Bronchoalveolar lavage was performed in 6 cases of invasive pulmonary aspergillosis and in 15 controls. Althoughbronchoalveolar lavage proved negative in 93 % of controls it did not detect IPA in 86 % of the cases. Remarkablypost mortem histology convincingly supported the presence of Aspergillus hyphae in lung tissue from a single casewhich had consecutive positive polymerase chain reaction assay results but was misdiagnosed by both computedtomography and consistently negative galactomannan assay results. For the galactomannan enzyme-immunoassay thediagnostic odds ratio was 15.33 and for the polymerase chain reaction assay it was 28.67. According to Cohen's kappaour in-house polymerase chain reaction method showed a fair agreement with the galactomannan immunoassay.Combined analysis of the results from the Aspergillus galactomannan enzyme immunoassay together with thosegenerated by our polymerase chain reaction assay led to no misdiagnoses in the control group.Conclusion: The data from this pilot-study demonstrate that the consideration of standard clinical methods combinedwith biomarker testing improves the capacity to make early and more accurate diagnostic decisions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Invasive pulmonary aspergillosis
Biomarkers
Combination testing
Acute leukemia
Neutropenic fever
Megjelenés:BMC Infectious Diseases. - 15 : 1 (2015), p. 251. -
További szerzők:Fidler Gábor (1987-) (molekuláris biológus, genetikus) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Rejtő László (1963-) (belgyógyász, haematológus) Méhes Gábor (1966-) (patológus) Bukta Evelin Loeffler, Juergen Biró Sándor (1949-) (molekuláris genetikus)
Pályázati támogatás:SROP-4.2.2.B-15/1/KONV-2015-0001
Egyéb
TÁMOP-4.2.4.A/ 2-11/1-2012-0001
TÁMOP
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7.

001-es BibID:BIBFORM016074
Első szerző:Szabó Judit (szakorvos, klinikai mikrobiológus)
Cím:Phenotypic and genetic characterisation of methicillin-resistant Staphylococcus aureus strains isolated from the university hospitals of Debrecen / Szabó, J., Dombrádi, Z., Dobay, O., Orosi, P., Kónya, J., Nagy, K., Rozgonyi, F.
Dátum:2009
ISSN:0934-9723
Megjegyzések:The purpose of this study was to characterise methicillin-resistant Staphylococcus aureus (MRSA) strains isolated in 2005 at the university hospitals of Debrecen, Hungary. Three hundred and thirty-nine MRSA strains were isolated from 102 patients at 18 different clinics. Their sensitivity to oxacillin and ten other antibiotics was determined. For genotypic analysis, phage typing and pulsed-field gel electrophoresis (PFGE) was performed. The rate of MRSA strains increased to 7.2% in 2005, especially at the clinics of surgery, pulmonology and paediatrics. No vancomycin- or teicoplanin-resistant strains were found. The resistance to erythromycin, clindamycin and ciprofloxacin was nearly 100% and multi-resistance was very frequent. Fifty-eight percent of the isolates belonged to mixed phage types and 8% was non-typable.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal Of Clinical Microbiology & Infectious Diseases. - 28 : 2 (2009), p. 129-136. -
További szerzők:Dombrádi Zsuzsanna Rita (1983-) (molekuláris biológus, mikrobiológus) Dobay Orsolya Orosi Piroska (1956-) (kórházhigiéné, megelőző orvostan és népegészségtan szakorvos) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Nagy Károly (Budapest) Rozgonyi Ferenc (1938-) (biológus, mikrobiológus)
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8.

001-es BibID:BIBFORM076404
035-os BibID:(WoS)000490004300020 (Scopus)85070814450
Első szerző:Tóth Hajnalka (általános orvos)
Cím:Utilization of vector autoregressive and linear transfer models to follow up the antibiotic resistance spiral in Gram-negative bacteria from cephalosporin consumption to colistin resistance / Hajnalka Tóth, Adina Fésűs, Orsolya Kungler-Gorácz, Bence Balázs, László Majoros, Krisztina Szarka, Gábor Kardos
Dátum:2019
ISSN:1058-4838
Megjegyzések:BACKGROUND: Increasing antibiotic resistance may reciprocally affect consumption and lead to using broader-spectrum alternatives; a vicious cycle that may gradually limit therapeutic options. The study aims at demonstrating the abovementioned vicious cycle in Gram-negative bacteria and at showing the utility of vector autoregressive (VAR) models for analysis of time-series in explanatory and dependent roles simultaneously. METHODS: Monthly drug consumption data in defined daily doses per 100 bed-days and incidence densities of Gram-negative bacteria (Escherichia coli, Klebsiella spp., Pseudomonas aeruginosa and Acinetobacterbaumannii) resistant to cephalosporins or to carbapenems were analysed using VAR models. These were compared to linear transfer models used earlier. RESULTS: In case of all Gram-negative bacteria, cephalosporin consumption led to increasing cephalosporin resistance, which provoked carbapenem use and consequent carbapenem resistance, and finally increased colistin consumption, exemplifying the vicious cycle. Different species were involved in different manner, e.g. cephalosporin resistant Klebsiella spp. provoked carbapenem use less than E. coli or association between carbapenem resistance of P. aeruginosa and colistin use was weaker than in case of A. baumannii. Colistin use led to decreased carbapenem use and decreased carbapenem resistance of P. aeruginosa but not of A. baumannii. CONCLUSIONS: Vector autoregressive models allow analysis of consumption and resistance series in a bidirectional manner. The reconstructed resistance spiral involved cephalosporin use augmenting cephalosporin resistance primarily in E. coli. This led to increased carbapenem use, provoking spread of carbapenem resistant A. baumannii and consequent colistin use. Emergence of panresistance is fuelled by such antibiotic resistance spirals.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
time-series analysis
antibiotic consumption
carbapenem resistance
Megjelenés:Clinical Infectious Diseases. - 69 : 8 (2019), p. 1410-1421. -
További szerzők:Fésüs Adina (1978-) (gyógyszerész) Kungler-Gorácz Orsolya (1985-) (gyógyszerész) Balázs Bence (1991-) (PhD hallgató) Majoros László (1966-) (szakorvos, klinikai mikrobiológus) Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus) Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus)
Pályázati támogatás:ÚNKP-17-2
ÚNKP
Bolyai ösztöndíj
MTA
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