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1.

001-es BibID:BIBFORM109702
035-os BibID:(cikkazonosító)2238 (Scopus)85151612301 (WoS)000956763900001
Első szerző:Árokszállási Tamás (neurológus)
Cím:Elevated Blood Alcohol Concentration Is Associated with Improved Clinical Outcomes of Intravenous Thrombolysis Treatment in Acute Ischemic Stroke Patients : A Retrospective Study / Árokszállási Tamás, Balogh Eszter, Orbán-Kálmándi Rita, Pásztor Máté, Árokszállási Anita, Nagy Edit Boglárka, Belán Ivett, May Zsolt, Csépány Tünde, Csiba László, Bagoly Zsuzsa, Oláh László
Dátum:2023
ISSN:2077-0383
Megjegyzések:Background: Intravenous thrombolysis (IVT) improves acute ischemic stroke (AIS) outcomes, but with limited success. In addition, ethanol potentiates the effect of r-tPA in ischemia models. Methods: The effect of acute alcohol consumption on IVT outcomes was investigated in a retrospective cohort study. AIS patients with detectable blood alcohol concentration (BAC) during IVT were included (alcohol group; n = 60). For each case, 3 control subjects who underwent IVT but denied alcohol consumption were matched in terms of age, sex, affected brain area, and stroke severity. Outcomes were determined using the NIHSS at 7 days and the modified Rankin scale (mRS) at 90 days. Results: Patients were younger and had a less severe stroke than in a standard stroke study. Favorable long-term outcomes (mRS 0?2) occurred significantly more frequently in the alcohol group compared to controls (90% vs. 63%, p < 0.001). However, the rates of hemorrhagic transformation were similar. Multiple logistic regression models identified elevated BAC as a significant protective factor against unfavorable short-term (OR: 0.091, 95% CI: 0.036?0.227, p < 0.001) and long-term outcomes (OR: 0.182, 95% CI: 0.062?0.535, p = 0.002). In patients with BAC > 0.2%, significantly lower NIHSS was observed at 3 and 7 days after IVT vs. in those with 0.01?0.2% ethanol levels. Conclusion: Elevated BAC is associated with improved outcomes in IVT-treated AIS without affecting safety.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
stroke
observational study
thrombolysis
ethanol
outcomes
Megjelenés:Journal of Clinical Medicine. - 12 : 6 (2023), p. 1-13. -
További szerzők:Balogh Eszter (1991-) (neurológus) Orbán-Kálmándi Rita Angéla (1993-) (klinikai laboratóriumi kutató) Pásztor Máté Árokszállási Anita (1982-) (orvos) Nagy Edit Boglárka Belán Ivett May Zsolt Csépány Tünde (1956-) (neurológus, pszichiáter) Csiba László (1952-) (neurológus, pszichiáter) Bagoly Zsuzsa (1978-) (orvos) Oláh László (1967-) (neurológus)
Pályázati támogatás:Nemzeti Agykutatási Program (NAP) 2017-1.2.1-NKP-2017-00002
Egyéb
ELKH-DE Cerebrovascularis Kutatócsoport
MTA
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2.

001-es BibID:bibEBI00026273
035-os BibID:(cikkazonosító)E3050 (WoS)000581708900001 (Scopus)85108175368
Első szerző:Bagoly Zsuzsa (orvos)
Cím:Uninterrupted Dabigatran Administration Provides Greater Inhibition against Intracardiac Activation of Hemostasis as Compared to Vitamin K Antagonists during Cryoballoon Catheter Ablation of Atrial Fibrillation / Zsuzsa Bagoly, Orsolya Hajas, Réka Urbancsek, Alexandra Kiss, Edit Fiak, Ferenc Sarkady, Noémi Klára Tóth, Rita Orbán-Kálmándi, Kitti Bernadett Kovács, László Nagy, Attila Nagy, János Kappelmayer, László Csiba, Zoltán Csanádi
Dátum:2020
ISSN:2077-0383
Megjegyzések:Background. Cerebral thromboembolism is a rare but feared complication of transcatheter ablation in patients with atrial fibrillation (AF). Here, we aimed to test which pre-procedural anticoagulation strategy results in less intracardiac activation of hemostasis during ablation. Patients and methods. In this observational study, 54 paroxysmal / persistent AF patients undergoing cryoballoon ablation were grouped according to their periprocedural anticoagulation strategy: no anticoagulation (oral anticoagulation (OAC) free; n = 24), uninterrupted vitamin K antagonists (VKA) ( n = 11), uninterrupted dabigatran ( n = 17). Blood was drawn from the left atrium before and immediately after the ablation procedure. Cryoablations were performed according to standard protocols, during which heparin was administered. Heparin-insensitive markers of hemostasis and endothelial damage were tested from intracardiac samples: D-dimer, quantitative fibrin monomer (FM), plasmin-antiplasmin complex (PAP), von Willebrand factor (VWF) antigen, chromogenic factor VIII (FVIII) activity. Results. D-dimer increased significantly in all groups post-ablation, with lowest levels in the dabigatran group (median [interquartile range]: 0.27 [0.36] vs. 1.09 [1.30] and 0.74 [0.26] mg / L in OAC free and uninterrupted VKA groups, respectively, p < 0.001 ). PAP levels were parallel to this observation. Post-ablation FM levels were elevated in OAC free ( 26.34 [30.04] mg / L ) and VKA groups (10.12 [16.01] mg / L), but remained below cut-o in all patients on dabigatran ( 3.98 [2.0] mg / L; p < 0.001). VWF antigen and FVIII activity increased similarly post-ablation in all groups, suggesting comparable procedure-related endothelial damage. Conclusion. Dabigatran provides greater inhibition against intracardiac activation of hemostasis as compared to VKAs during cryoballoon catheter ablation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
atrial fibrillation
cryoballoon ablation;
dabigatran
vitamin K antagonists
Megjelenés:Journal of Clinical Medicine. - 9 : 9 (2020), p. 1-13. -
További szerzők:Hajas Orsolya (1987-) Urbancsek Réka (1991-) (általános orvos) Kiss Alexandra (1987-) (általános orvos) Fiák Edit Sarkady Ferenc (1982-) (laboratóriumi analitikus) Tóth Noémi Klára Orbán-Kálmándi Rita Angéla (1993-) (klinikai laboratóriumi kutató) Kovács Kitti Bernadett (1985-) (neurológus) Nagy László Tibor (1969-) (belgyógyász, kardiológus) Nagy Attila Csaba (1981-) (megelőző orvostan és népegészségtan szakorvos, epidemiológus) Kappelmayer János (1960-) (laboratóriumi szakorvos) Csiba László (1952-) (neurológus, pszichiáter) Csanádi Zoltán (1960-) (kardiológus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00043
GINOP
MTA-DE
MTA
K109712
OTKA
K120042
OTKA
FK128582
OTKA
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM083072
Első szerző:Csikai Enikő
Cím:Influence of angiotensin-converting enzyme inhibition on reversibility of alterations in arterial wall and cognitive performance associated with early hypertension : a follow-up study / Csikai Enikő, Andrejkovics Mónika, Balajthy-Hidegh Bernadett, Hofgárt Gergely, Kardos László, Diószegi Ágnes, Rostás Róbert, Czuriga-Kovács Katalin Réka, Csongrádi Éva, Csiba László
Dátum:2019
ISSN:0025-7974
Megjegyzések:The importance of optimal blood pressure control for preventing or reducing the impairment of vascular and cognitive functions is well known. However, the reversibility of early alterations in vascular and cognitive functions through antihypertensive agents is under-investigated. In this study, we evaluated the influence of 3 months of angiotensin-converting enzyme (ACE) inhibition treatment on the morphological and functional arterial wall and cognitive performance changes in 30 newly diagnosed primary hypertensive patients. Common carotid intima-media thickness (IMT) and brachial artery flow-mediated dilatation (FMD) were detected by ultrasonography. Arterial stiffness indicated by augmentation index (AIx) and pulse wave velocity (PWV) was assessed by arteriography. Cognitive functions were assessed by neuropsychological examination. The executive function overall score was significantly higher at 3-month follow-up than at baseline (median, 0.233 (IQR, 0.447) vs ?0.038 (0.936); P?=?.001). Three-month ACE inhibition did not produce significant improvement in IMT, FMD, AIx and PWV values. Significant negative associations were revealed between IMT and complex attention (r?=??0.598, P?=?.0008), executive function (r?=??0.617, P?=?.0005), and immediate memory (r?=??0.420, P?=?.026) overall scores at follow-up. AIx had significant negative correlations with complex attention (r?=??0.568, P?=?.001), executive function (r?=??0.374, P?=?.046), and immediate memory (r?=??0.507, P?=?.005). PWV correlated significantly and negatively with complex attention (r?=??0.490, P?=?.007). Timely and effective antihypertensive therapy with ACE inhibitors has significant beneficial effects on cognitive performance in as few as 3 months. Early ACE inhibition may have an important role in the reversal of initial impairments of cognitive function associated with hypertension-induced vascular alterations.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
arterial stiffness
carotid intima-media thickness
cognition
flow-mediated vasodilatation
hypertension
Megjelenés:Medicine. - 98 : 34 (2019), p. 1-9. -
További szerzők:Andrejkovics Mónika (1967-) (klinikai szakpszichológus, neuropszichológus, pszichoterapeuta) Balajthy-Hidegh Bernadett Hofgárt Gergely (1984-) (neurológus) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Diószegi Ágnes (1987-) (belgyógyász) Rostás Róbert (1991-) (Orvos) Czuriga-Kovács Katalin Réka (1981-) (neurológus) Csongrádi Éva (1969-) (szakorvos) Csiba László (1952-) (neurológus, pszichiáter)
Pályázati támogatás:GINOP-2.3.2-15-2016-00048
GINOP
Gedeon Richter research grant 4700168520-KK/186/2016
Egyéb
NKFI K120042
Egyéb
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM015756
Első szerző:Emri Miklós (fizikus)
Cím:The importance of MRI-PET registration in clinical routine / M. Emri, G. Opposits, L. Trón, Á. Klekner, L. Novák, J. Kollár, L. Bognár, E. Berényi
Dátum:2007
Megjegyzések:Registered images produced by MRI based multi-modality image processing are essential tools of diagnostic and surgical planning of neurological and neurosurgical diseases. The aim of this study was to investigate how fused images produced by various MRI (T1, T2, fMRI, DTI, MRS) and PET (FDG, Metionine) data can be used in clinical routine. Material and methods: In our study the complex multi-modality tomographic data sets of 6 patients (3 glioblastoma, 2 oligoastrocitóma és 1 pilocitás astrocitoma) were used. For the image registration as well as the production of 2D- and 3D fused images free, commercial and in-house developed software were utilized. Result: We found that our images significantly assisted clinicians in preparing therapeutic and surgical plans. Optimizing the established software and automatizing image registration tasks needs further development.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Nuclear Medicine Review. - 10 : 1 (2007), p. 59. -
További szerzők:Opposits Gábor (1974-) (fizikus, szoftver fejlesztő) Trón Lajos (1941-) (biofizikus) Klekner Álmos (1970-) (idegsebész) Novák László (1964-) (idegsebész) Kollár József (1950-) (radiológus) Bognár László (1958-) (idegsebész, gyermekidegsebész) Berényi Ervin (1964-) (radiológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM022889
Első szerző:Garai Ildikó (radiológus)
Cím:Comparison of hemispherical cerebral blood flow in various cerebral diseases with quantitative HMPAO imaging / I. Garai, E. Szomják, J. Varga, Cs. Tóth, S. Olvasztó, A. Ficzere, L. Galuska
Dátum:2001
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
comparison
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal of the Nuclear Medicine. - 28 : 8 (2001), p. 1047. -
További szerzők:Szomják Edit (1961-) (belgyógyász) Varga József (1955-) (fizikus) Tóth Csaba (1968-) (sebész, érsebész) Olvasztó Sándor (1957-) (sebész) Ficzere Andrea (1967-) (neurológus) Galuska László (1946-) (belgyógyász, izotópdiagnoszta)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM021442
Első szerző:Garai Ildikó (radiológus)
Cím:Quantitative assessment of blood flow reserve using 99m Tc-HMPAO in carotid stenosis / I. Garai, J. Varga, E. Szomják, C. Tóth, J. Bánk, A. Ficzere, S. Olvasztó, L. Galuska
Dátum:2002
ISSN:1619-7070
Megjegyzések:Dynamic imaging of the inflow of technetium-99m hexamethylpropylene amine oxime (HMPAO) to the brain has been proved to allow estimation of the hemispherical cerebral blood flow (CBF) using the Patlak plot. In this study, we compared the hemispherical CBF (in ml/min/100 g) of different patient groups. A total of 25 patients (comprising 13 with migraine and 12 scheduled for endarterectomy owing to angiographically confirmed severe stenosis of the internal carotid artery on at least one side) underwent baseline and acetazolamide 99mTc-HMPAO brain perfusion studies. In addition, acetazolamide 99mTc-HMPAO studies were performed in 12 healthy subjects (no baseline study was performed for ethical reasons.) Dynamic studies were acquired by means of a dual-detector gamma camera with a large field of view (HELIX, Elscint). Special difference images were created to make definition of the aortic arch and hemispherical brain regions easier and more reproducible. A semi-automatic method was developed to determine the transit time from the aorta to the brain, making the generation of the Patlak plot even more robust. The baseline CBF values did not significantly depend on the disease (P>0.1), whereas the CBF values obtained after acetazolamide provocation did do so (ANOVA, P<0.001). Patients suffering from migraine showed a significant increase in global CBF values after acetazolamide provocation (paired t test, P<0.05), but we could not find any effect of the provocation in patients awaiting carotid endarterectomy, indicating a lack of cerebrovascular reserve capacity. Comparison of the results of the acetazolamide study in patients and the control group revealed the CBF values to be significantly lower in patients with carotid stenosis (two-sample t-test, P<0.001), but not in those with migraine (P>0.1). In summary, using quantitative analysis of 99mTc-HMPAO brain studies we could objectively compare the CBF of patients suffering from different diseases. Especially the CBF values obtained after acetazolamide provocation permitted effective differentiation of disease states. The quantitative results may be of assistance in therapy planning, e.g. in selection of the correct operative technique.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
quantitativ assessment
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal of Nuclear Medicine and Molecular Imaging. - 29 : 2 (2002), p. 216-220. -
További szerzők:Varga József (1955-) (fizikus) Szomják Edit (1961-) (belgyógyász) Tóth Csaba (1968-) (sebész, érsebész) Bánk József (1950-) (neurológus) Ficzere Andrea (1967-) (neurológus) Olvasztó Sándor (1957-) (sebész) Galuska László (1946-) (belgyógyász, izotópdiagnoszta)
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Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM033467
Első szerző:Grüne, Matthias
Cím:Quantitative T*(2) and T'(2) maps during reversible focal cerebral ischemia in rats : separation of blood oxygenation from nonsusceptibility-based contributions / Grüne M., van Dorsten F. A., Schwindt W., Oláh L., Hoehn M.
Dátum:2000
Megjegyzések:Quantitative imaging contrast is evaluated which allows the selective measurement of the blood oxygenation state during cerebral ischemia within a multiparametric imaging study on rats. In a first step, the ambiguities arising in T*(2)-weighted images due to T*(2) heterogeneity are eliminated by calculating T*(2) maps. Then, 1/T'(2) maps are calculated according to 1/T'(2) = 1/T*(2) - 1/T(2) to eliminate nonsusceptibility-induced changes of 1/T*(2) after the induction of stroke. This is of particular importance in the presence of vasogenic edema. The changes Delta(1/T'(2)) after the onset of ischemia selectively quantify the variations of the deoxyhemoglobin content during the development of the infarct. The presented results are not available from conventionally recorded parameters of a stroke study and, together with perfusion-weighted images, form a powerful combination to analyze the oxygen consumption and the metabolism of the tissue.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Magnetic Resonance in Medicine. - 42 : 6 (2000), p. 1027-1032. -
További szerzők:van Dorsten, Ferdi A. Schwindt, Wolfram Oláh László (1967-) (neurológus) Hoehn, Mathias
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8.

001-es BibID:BIBFORM095313
035-os BibID:(cikkazonosító)e20202411 (WoS)000657498100002 (Scopus)85107071783
Első szerző:Heindl, Steffanie
Cím:Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies / Steffanie Heindl, Alessio Ricci, Olga Carofiglio, Qihui Zhou, Thomas Arzberger, Nikolett Lenart, Nicolai Franzmeier, Tibor Hortobagyi, Peter T. Nelson, Ann M. Stowe, Adam Denes, Dieter Edbauer, Arthur Liesz
Dátum:2021
ISSN:0022-1007 1540-9538
Megjegyzések:Neuroinflammation is an emerging focus of translational stroke research. Preclinical studies have demonstrated a critical role for brain-invading lymphocytes in post-stroke pathophysiology. Reducing cerebral lymphocyte invasion by anti-CD49d antibodies consistently improves outcome in the acute phase after experimental stroke models. However, clinical trials testing this approach failed to show efficacy in stroke patients for the chronic outcome 3 mo after stroke. Here, we identify a potential mechanistic reason for this phenomenon by detecting chronic T cell accumulation?evading the systemic therapy?in the post-ischemic brain. We observed a persistent accumulation of T cells in mice and human autopsy samples for more than 1 mo after stroke. Cerebral T cell accumulation in the post-ischemic brain was driven by increased local T cell proliferation rather than by T cell invasion. This observation urges re-evaluation of current immunotherapeutic approaches, which target circulating lymphocytes for promoting recovery after stroke.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Experimental Medicine. - 218 : 8 (2021), p. 1-14. -
További szerzők:Ricci, Alessio Carofiglio, Olga Zhou, Qihui Arzberger, Thomas Lénárt Nikolett Franzmeier, Nicolai Hortobágyi Tibor (1965-) (patológus) Nelson, Peter T. Stowe, Ann M. Dénes Ádám Edbauer, Dieter Liesz, Arthur
Pályázati támogatás:Nemzeti Agykutatási Program 2017-1.2.1-NKP-2017-00002
Egyéb
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Intézményi repozitóriumban (DEA) tárolt változat
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9.

001-es BibID:BIBFORM014848
Első szerző:Juhász Béla (kísérletes farmakológus)
Cím:Postischemic cardiac recovery in heme oxygenase-1 transgenic ischemic/reperfused mouse myocardium / Bela Juhasz, Balazs Varga, Attila Czompa, Istvan Bak, Istvan Lekli, Rudolf Gesztelyi, Judit Zsuga, Adam Kemeny-Beke, Miklos Antal, Levente Szendrei, Arpad Tosaki
Dátum:2011
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekulatudomány
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal of Cellular and Molecular Medicine. - 15 : 9 (2011), p. 1973-1982. -
További szerzők:Varga Balázs (1984-) (kísérletes farmakológus) Czompa Attila (1985-) (gyógyszerész) Bak István (1975-) (vegyész, analitikus, farmakológus) Lekli István (1981-) (gyógyszerész) Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Zsuga Judit (1973-) (neurológus, pszichoterapeuta, egészségügyi szakmanager) Kemény-Beke Ádám (1968-2021) (szemész) Antal Miklós (1951-) (orvos, anatómus) Szendrei Levente Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész)
Pályázati támogatás:K 72315
OTKA
PD 78223
OTKA
TÁMOP-4.2.2-08/1-2008-0007
TÁMOP
Kardiovaszkuláris megbetegedések génterápiás befolyásolása
TÁMOP-4.2.1.B-2010
TÁMOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

10.

001-es BibID:BIBFORM095684
035-os BibID:(WoS)000635685600001 (Scopus)85103399984
Első szerző:Kešnerová, Petra
Cím:Peripheral Vascular Resistance in Cerebral Arteries in Patients With Carotid Atherosclerosis - Substudy Results of the Atherosclerotic Plaque Characteristics Associated with a Progression Rate of the Plaque and a Risk of Stroke in Patients With the Carotid Bifurcation Plaque Study (ANTIQUE) / Petra Kešnerová, David Školoudík, Roman Herzig, David Netuka, Istvan Szegedi, Kateřina Langová, ANTIQUE Trial Group
Dátum:2022
ISSN:0278-4297
Megjegyzések:Objectives Transcranial color-coded duplex sonography (TCCS) enables to measure blood flow characteristics in cerebral vessels, including vascular resistance and pulsatility. The study aims to identify factors influencing pulsatility (PI) and resistance (RI) indices measured using TCCS in patients with carotid atherosclerosis. Methods Self-sufficient patients with atherosclerotic plaque causing 20-70% carotid stenosis were consecutively enrolled to the study. All patients underwent duplex sonography of cervical arteries and TCCS with measurement of PI and RI in the middle cerebral artery, neurological, and physical examinations. Following data were recorded: age, gender, height, weight, body mass index, systolic and diastolic blood pressure, occurrence of current and previous diseases, surgery, medication, smoking, and daily dose of alcohol. Univariant and multivariant logistic regression analysis were used for identification of the factors influencing RI and PI. Results Totally 1863 subjects were enrolled to the study: 139 healthy controls (54 males, age 55.52 +/- 7.05 years) in derivation cohort and 1724 patients (777 males, age 68.73 +/- 9.39 years) in validation cohort. The cut off value for RI was 0.63 and for PI 1.21. Independent factors for increased RI/PI were age (odds ratio [OR] = 1.108/1.105 per 1 year), occurrence of diabetes mellitus (OR = 1.767/2.170), arterial hypertension (OR = 1.700 for RI only), width of the carotid plaque (OR = 1.260 per 10% stenosis for RI only), and male gender (OR = 1.530 for PI only; P <.01 in all cases). Conclusions The independent predictors of increased cerebral arterial resistance and/or pulsatility in patients with carotid atherosclerosis were age, arterial hypertension, diabetes mellitus, carotid plaque width, and male gender.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Ultrasound In Medicine. - 41 : 1 (2022), p. 237-246. -
További szerzők:Školoudík, David (1968-) Herzig, Roman (1968-) Netuka, David (1968-) Szegedi István (1992-) (orvos) Langová, Kateřina (1968-) (Általános orvos) ANTIQUE Trial Group
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Intézményi repozitóriumban (DEA) tárolt változat
Borító:

11.

001-es BibID:BIBFORM042437
Első szerző:Léránt Brigitta
Cím:The role of extracranial ultrasound in the prevention of stroke based on the new guidelines / Brigitta Léránt, László Csiba
Dátum:2012
ISSN:2211-968X
Megjegyzések:Extracranial ultrasonography is recommended to use as a baseline non-invasive method in the initial evaluation of either asymptomatic or symptomatic patients to define the possible stenosis on carotid artery. The latest 2011 guidelines specify the sequence of examinations with certain classification of recommendations and level of evidence. Carotid duplex ultrasonography plays an important role both in primary and secondary prevention of stroke and the results found determine the use of further investigations and management of patients with extracranial carotid and vertebral artery disease. In case of diagnostic uncertainty other brain imaging methods, like computed tomography angiography, magnetic resonance angiography and catheter-based angiography can be chosen to assess vascular lesions. Carotid duplex ultrasound serves not only diagnostic purposes but can also be useful in the follow up processes. It is widely used for control examinations after revascularization procedures of the carotid or vertebrobasilar arteries. By the establishment of indications of revascularization procedures degree of carotid stenosis is a major factor which therefore requires accuracy of the assessment. Carotid duplex ultrasound has some difficulties in this question. This diagnostic uncertainty is tried to be solved by improving the criteria system of stenosis grading in internal carotid artery. The aim of this article is to give an overview about the importance and role of extracranial duplex ultrasonography in stroke prevention based on the latest guidelines.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Perspectives in Medicine 1 : 1-12 (2012), p. 94-99. -
További szerzők:Csiba László (1952-) (neurológus, pszichiáter)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM042412
Első szerző:Léránt Brigitta
Cím:Morphological, hemodynamic and stiffness changes in arteries of young smokers / Brigitta Léránt, Christina Straesser, Réka Katalin Kovács, László Oláh, László Kardos, László Csiba
Dátum:2012
ISSN:2211-968X
Megjegyzések:Aim The aim of our investigations was to detect the acute and chronic effects of cigarette smoking on arterial wall thickness and stiffness in young, healthy volunteers. We also performed a one-year follow-up to define the possible changes. Subjects We recruited 25 non-smoking and 25 smoking university students aged 19-33. Exclusion criteria were any known diseases, abnormally high cholesterol levels and body mass index (BMI) above 30 kg/m2. Methods We defined the intima-media thickness on both common carotid arteries by using B-mode ultrasonography and we measured the hemodynamic and stiffness parameters with the help of arteriograph. In case of smokers we also investigated the acute effects after smoking one cigarette. In the follow-up study we measured 15 non-smokers and 13 smokers again. Results In the smoking group morphological, stiffness and hemodynamic parameters showed significantly higher values compared to non-smokers. Concerning the acute effects we detected a significant increase in stiffness and hemodynamic parameters after smoking one cigarette. Gender differences were also found in the smoking group. Unadjusted to age, gender and smoking status there was a significant correlation between intima-media thickness and pulse wave velocity. We could not find any progression in smokers after one year, while there was an improvement in intima-media thickness and augmentation index in non-smokers. Conclusion Early atherosclerotic processes due to smoking can be detected even at a young age, in healthy university students. One year regular smoking does not result in detectable changes.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Perspectives in Medicine. - 1 : 1-12 (2012), p. 152-155. -
További szerzők:Straesser, Christina Czuriga-Kovács Katalin Réka (1981-) (neurológus) Oláh László (1967-) (neurológus) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Csiba László (1952-) (neurológus, pszichiáter)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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